Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities.

abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...

journal_title：Neuromolecular medicine

authors： Luo S,Xu H,Zuo Y,Liu X,All AH

更新日期：2020-12-01 00:00:00

abstract：:Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cor...

journal_title：Neuromolecular medicine

authors： Liu SB,Zhao R,Li XS,Guo HJ,Tian Z,Zhang N,Gao GD,Zhao MG

更新日期：2014-06-01 00:00:00

abstract：:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D ...

journal_title：Neuromolecular medicine

authors： Gezen-Ak D,Alaylıoğlu M,Genç G,Gündüz A,Candaş E,Bilgiç B,Atasoy İL,Apaydın H,Kızıltan G,Gürvit H,Hanağası H,Ertan S,Yılmazer S,Dursun E

更新日期：2017-03-01 00:00:00

abstract：:Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder known as manganism is associated with the preferential accumulation of Mn in the globus pallidus of the basal ganglia which is generally considered to be the m...

journal_title：Neuromolecular medicine

authors： Roth JA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...

journal_title：Neuromolecular medicine

authors： Chen HL,Jia WJ,Li HE,Han H,Li F,Zhang XL,Li JJ,Yuan Y,Wu CY

更新日期：2020-06-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00

abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...

journal_title：Neuromolecular medicine

authors： Benvenuti S,Deledda C,Luciani P,Modi G,Bossio A,Giuliani C,Fibbi B,Peri A

更新日期：2013-09-01 00:00:00

abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...

journal_title：Neuromolecular medicine

authors： Kaye DM,Esler MD

更新日期：2008-01-01 00:00:00

abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

journal_title：Neuromolecular medicine

authors： Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

更新日期：2016-09-01 00:00:00

abstract：:Millions of individuals with active TB do not receive recommended treatments, and instead may use botanicals, or use botanicals concurrently with established treatments. Many botanicals protect against oxidative stress, but this can interfere with redox-dependent activation of isoniazid and other prodrugs used for pro...

journal_title：Neuromolecular medicine

authors： Folk WR,Smith A,Song H,Chuang D,Cheng J,Gu Z,Sun G

更新日期：2016-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

journal_title：Neuromolecular medicine

authors： Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

更新日期：2020-06-01 00:00:00

abstract：:Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophil proteinase 3), and from many other cell types (e.g., trypsins) can specifically signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled recepto...

journal_title：Neuromolecular medicine

authors： Saito T,Bunnett NW

更新日期：2005-01-01 00:00:00

abstract：:Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor sympto...

journal_title：Neuromolecular medicine

authors： Sanjari Moghaddam H,Valitabar Z,Ashraf-Ganjouei A,Mojtahed Zadeh M,Ghazi Sherbaf F,Aarabi MH

更新日期：2018-09-01 00:00:00

abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...

journal_title：Neuromolecular medicine

authors： Shy ME

更新日期：2006-01-01 00:00:00

abstract：:It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find o...

journal_title：Neuromolecular medicine

authors： Hosseini A,Khazali H

更新日期：2018-12-01 00:00:00

abstract：:A methylation-based EWAS on carefully phenotyped individuals with Parkinson's disease (PD) was conducted to reveal prioritised genes and pathways with statistically significant and sizable changes in PD and in the anxiety that often accompanies it. This was followed by subsequent replication of top-ranked CpG sites. U...

journal_title：Neuromolecular medicine

authors： Moore K,McKnight AJ,Craig D,O'Neill F

更新日期：2014-12-01 00:00:00

abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

journal_title：Neuromolecular medicine

authors： Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

更新日期：2016-03-01 00:00:00

abstract：:Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplementation of laboratory...

journal_title：Neuromolecular medicine

authors： Cansev M

更新日期：2016-09-01 00:00:00

abstract：:Substantial evidence indicates bioenergetic dysfunction and mitochondrial impairment contribute either directly and/or indirectly to the pathogenesis of numerous neurodegenerative disorders. Treatment paradigms aimed at ameliorating this cellular energy deficit and/or improving mitochondrial function in these neurodeg...

journal_title：Neuromolecular medicine

authors： Adhihetty PJ,Beal MF

更新日期：2008-01-01 00:00:00

abstract：:The α-synuclein gene (SNCA) plays a major role in the aetiology of Lewy body disease (LBD) including Parkinson's disease (PD). Point mutations and genetic alterations causing elevated gene expression are causally linked to familial PD. To what extent epigenetic changes play a role in the regulation of α-synuclein expr...

journal_title：Neuromolecular medicine

authors： de Boni L,Tierling S,Roeber S,Walter J,Giese A,Kretzschmar HA

更新日期：2011-12-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00

abstract：:Origins of onset and progression of motor neurodegeneration in amyotrophic lateral sclerosis (ALS) are not clearly known, but may include impairment of mitochondrial bioenergetics. We used quantitative PCR approaches to analyze the mitochondrial oxidative phosphorylation (OXPHOS) transcriptomes of spinal cord tissue a...

journal_title：Neuromolecular medicine

authors： Ladd AC,Keeney PM,Govind MM,Bennett JP Jr

更新日期：2014-12-01 00:00:00

abstract：:Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases...

journal_title：Neuromolecular medicine

authors： Reddy PH

更新日期：2008-01-01 00:00:00

abstract：:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-cat...

journal_title：Neuromolecular medicine

authors： Busby V,Goossens S,Nowotny P,Hamilton G,Smemo S,Harold D,Turic D,Jehu L,Myers A,Womick M,Woo D,Compton D,Doil LM,Tacey KM,Lau KF,Al-Saraj S,Killick R,Pickering-Brown S,Moore P,Hollingworth P,Archer N,Foy C,Wal

更新日期：2004-01-01 00:00:00

abstract：:He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared for and had removed and processed their brain tissues upon their death. His disc...

journal_title：Neuromolecular medicine

authors： Mattson MP

更新日期：2011-03-01 00:00:00

abstract：:Adiponectin, an adipocytokine released by the adipose tissue and has important roles in the metabolic regulation and inflammatory control, may play an important roles in the physiopathology of psychiatric and neurodegenerative disorders. The aim of the present work was to evaluate adiponectin serum levels in patients ...

journal_title：Neuromolecular medicine

authors： Teixeira AL,Diniz BS,Campos AC,Miranda AS,Rocha NP,Talib LL,Gattaz WF,Forlenza OV

更新日期：2013-03-01 00:00:00

abstract：:Aluminum (Al) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of Al in arbitrating glia homeostasis and pathophysiology remains obscure. Astrocyte, microglia activation (reactive gliosis), and associated inflammatory events play a decisive role in neuro...

journal_title：Neuromolecular medicine

authors： Prakash D,Gopinath K,Sudhandiran G

更新日期：2013-03-01 00:00:00

abstract：:Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase. Disease variants alter the enzyme's substrate specificity and lead to accumulation of neurotoxic 1-deoxysphingolipids. We de...

journal_title：Neuromolecular medicine

authors： Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Schön U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

更新日期：2016-03-01 00:00:00

abstract：:Neurodegeneration is the main pathological correlate of accumulating disability in progressive stages of Multiple Sclerosis (MS), but both histologic and imaging studies detect significant tissue loss even in early disease. These observations raise the question as to whether neurodegeneration in MS is a primary mechan...

journal_title：Neuromolecular medicine

authors： Kalman B,Leist TP

更新日期：2003-01-01 00:00:00

abstract：:Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...

journal_title：Neuromolecular medicine

authors： Korn T,Rao M,Magnus T

更新日期：2007-01-01 00:00:00