Cytochrome C and caspase-9 expression in Huntington's disease.

Abstract:

:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner caspases. In the present study, we examined the distribution of cytochrome c and caspase-9 in Huntington's disease (HD) patients and in a transgenic model of HD (R6/2 line). Neuronal cytochrome c immunoreactivity increased with neuropathological severity in HD patients. Concomitant with this finding, Western-blot analysis showed a shift in the distribution of cytochrome c from the mitochondrial to the cytosolic fraction with incremental cytosolic expression associated with greater striatal degeneration. Active caspase-9 immunoreactivity was present in both HD striatal neurons and in Western blots of severe-grade specimens. Similar findings were observed in the R6/2 mice. There was a temporal increase in expression and shift of cytochrome c from the mitochondrial to the cytosolic fraction from 4-13 wk of age. Activated caspase-9 and caspase 3 activities were present only at endstage disease. Although the present results provide evidence that key components of the intrinsic mitochondrial apoptotic pathway are activated in both HD patients and a transgene murine model of HD, these phenomena are prominent in only severe neuropathological grades in HD patients and HD mice, suggesting that apoptosis may play a greater role in neuronal death at endstage disease.

journal_name

Neuromolecular Med

journal_title

Neuromolecular medicine

authors

Kiechle T,Dedeoglu A,Kubilus J,Kowall NW,Beal MF,Friedlander RM,Hersch SM,Ferrante RJ

doi

10.1385/NMM:1:3:183

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

183-95

issue

3

eissn

1535-1084

issn

1559-1174

pii

NMM:1:3:183

journal_volume

1

pub_type

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