GC and VDR SNPs and Vitamin D Levels in Parkinson's Disease: The Relevance to Clinical Features.

Abstract:

:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D transport, to determine whether vitamin D receptor (VDR) haplotype that we previously demonstrated to be a risk haplotype for AD is also a common haplotype for PD and to investigate any relevant consequence of serum 25OHD levels, GC or VDR genotypes on clinical features of PD. Three hundred eighty-two PD patients and 242 healthy subjects were included in this study. The serum 25OHD levels were investigated by CLIA, and GC and VDR SNPs were evaluated with LightSnip. Our results indicated a strong relationship between low serum 25OHD levels and PD (p < 0.001). rs7041 of GC and ApaI of VDR were associated with the PD risk (p < 0.05). Minor allele carriers for BsmI of VDR gene in both PD patients and healthy subjects had significantly higher levels of serum 25OHD (p < 0.05). The homozygous major allele carriers for rs2282679, rs3755967 and rs2298850 of GC gene in PD patients with slower progression had significantly higher levels of serum 25OHD (p  < 0.05). Minor allele carriers for FokI of VDR gene were more frequent in patients with advanced-stage PD (p < 0.05). Consequently, this is the first study demonstrating GC gene as a risk factor for PD. The relationship between PD's clinical features and low 25OHD or risk genotypes might have effects on PD independently.

journal_name

Neuromolecular Med

journal_title

Neuromolecular medicine

authors

Gezen-Ak D,Alaylıoğlu M,Genç G,Gündüz A,Candaş E,Bilgiç B,Atasoy İL,Apaydın H,Kızıltan G,Gürvit H,Hanağası H,Ertan S,Yılmazer S,Dursun E

doi

10.1007/s12017-016-8415-9

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

24-40

issue

1

eissn

1535-1084

issn

1559-1174

pii

10.1007/s12017-016-8415-9

journal_volume

19

pub_type

杂志文章
  • Perturbed autonomic nervous system function in metabolic syndrome.

    abstract::The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-008-8022-5

    authors: Tentolouris N,Argyrakopoulou G,Katsilambros N

    更新日期:2008-01-01 00:00:00

  • Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma.

    abstract::GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the ei...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-018-8507-9

    authors: Yu W,Liang S,Zhang C

    更新日期:2018-12-01 00:00:00

  • Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment.

    abstract::Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P1-S1P5. Scrutiny of S1P-regulated pathways over the past three decades has identified important and occasionally counteracting functions in the brain and cerebrovascular system. ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-020-08632-0

    authors: Chua XY,Ho LTY,Xiang P,Chew WS,Lam BWS,Chen CP,Ong WY,Lai MKP,Herr DR

    更新日期:2020-11-12 00:00:00

  • Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.

    abstract::Parkinson's disease (PD) features oxidative stress and accumulation of misfolded (unfolded, alternatively folded, or mutant) proteins with associated loss of dopaminergic neurons. Oxidative stress and the accumulated misfolded proteins elicit cellular responses that include an endoplasmic reticulum (ER) stress respons...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-008-8047-9

    authors: Chinta SJ,Rane A,Poksay KS,Bredesen DE,Andersen JK,Rao RV

    更新日期:2008-01-01 00:00:00

  • Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities.

    abstract::Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusio...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-020-08600-8

    authors: Yue Y,Zhao H,Yue Y,Zhang Y,Wei W

    更新日期:2020-09-01 00:00:00

  • Disregulation of Autophagy in the Transgenerational Cc2d1a Mouse Model of Autism.

    abstract::Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-019-08579-x

    authors: Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

    更新日期:2020-06-01 00:00:00

  • Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia.

    abstract::The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-016-8394-x

    authors: Yuan Y,Fang M,Wu CY,Ling EA

    更新日期:2016-09-01 00:00:00

  • Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism-Epilepsy Phenotype with Macrocephaly.

    abstract::The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-015-8378-2

    authors: Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

    更新日期:2016-03-01 00:00:00

  • Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.

    abstract::Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-013-8219-0

    authors: Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

    更新日期:2013-06-01 00:00:00

  • Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke.

    abstract::A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s12017-015-8365-7

    authors: Niu YM,Weng H,Zhang C,Yuan RX,Yan JZ,Meng XY,Luo J

    更新日期:2015-12-01 00:00:00

  • Novel mutations in cyclin-dependent kinase-like 5 (CDKL5) gene in Indian cases of Rett syndrome.

    abstract::Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-012-8212-z

    authors: Das DK,Mehta B,Menon SR,Raha S,Udani V

    更新日期:2013-03-01 00:00:00

  • Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.

    abstract::Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cor...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-013-8280-8

    authors: Liu SB,Zhao R,Li XS,Guo HJ,Tian Z,Zhang N,Gao GD,Zhao MG

    更新日期:2014-06-01 00:00:00

  • GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese.

    abstract::Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with fir...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-018-8485-y

    authors: Ye Z,Zhang H,Sun L,Cai H,Hao Y,Xu Z,Zhang Z,Liu X

    更新日期:2018-06-01 00:00:00

  • Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke.

    abstract::Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-011-8158-6

    authors: Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

    更新日期:2011-12-01 00:00:00

  • Is 1,8-Cineole-Rich Extract of Small Cardamom Seeds More Effective in Preventing Alzheimer's Disease than 1,8-Cineole Alone?

    abstract::The present study demonstrates the efficacies of synthetic 1,8-cineole and an 1,8-cineole-rich supercritical carbon dioxide (SC-CO2) extract of small cardamom seeds in preventing oligomerization of amyloid beta peptide (Aβ42) and inhibiting iron-dependent oxyradical production in vitro. The oligomerization of Aβ42 was...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-019-08574-2

    authors: Paul K,Ganguly U,Chakrabarti S,Bhattacharjee P

    更新日期:2020-03-01 00:00:00

  • Reduction of AP180 and CALM produces defects in synaptic vesicle size and density.

    abstract::Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using several invertebrate model systems have indicated a role for AP180 in SV recycl...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-012-8194-x

    authors: Petralia RS,Wang YX,Indig FE,Bushlin I,Wu F,Mattson MP,Yao PJ

    更新日期:2013-03-01 00:00:00

  • The cell biology of alpha-synuclein: a sticky problem?

    abstract::Parkinson's disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1385/NMM:1:2:95

    authors: Cole NB,Murphy DD

    更新日期:2002-01-01 00:00:00

  • Neuro-protective Mechanisms of Lycium barbarum.

    abstract::Neuronal diseases, including retinal disorders, stroke, Alzheimer's disease, Parkinson's disease and spinal cord injury, affect a large number of people worldwide and cause heavy social and economic burdens. Although many efforts have been made by scientists and clinicians to develop novel drug and healthcare strategi...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-016-8393-y

    authors: Xing X,Liu F,Xiao J,So KF

    更新日期:2016-09-01 00:00:00

  • Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington's disease.

    abstract::Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autop...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-013-8275-5

    authors: Chaudhary RK,Kardani J,Singh K,Banerjee R,Roy I

    更新日期:2014-06-01 00:00:00

  • Phytochemicals in Ischemic Stroke.

    abstract::Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-016-8403-0

    authors: Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

    更新日期:2016-09-01 00:00:00

  • Autoimmune modulation of astrocyte-mediated homeostasis.

    abstract::Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1385/nmm:9:1:1

    authors: Korn T,Rao M,Magnus T

    更新日期:2007-01-01 00:00:00

  • Cerebrospinal Fluid C-Reactive Protein in Parkinson's Disease: Associations with Motor and Non-motor Symptoms.

    abstract::Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor sympto...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-018-8499-5

    authors: Sanjari Moghaddam H,Valitabar Z,Ashraf-Ganjouei A,Mojtahed Zadeh M,Ghazi Sherbaf F,Aarabi MH

    更新日期:2018-09-01 00:00:00

  • Epigenome-wide association study for Parkinson's disease.

    abstract::A methylation-based EWAS on carefully phenotyped individuals with Parkinson's disease (PD) was conducted to reveal prioritised genes and pathways with statistically significant and sizable changes in PD and in the anxiety that often accompanies it. This was followed by subsequent replication of top-ranked CpG sites. U...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-014-8332-8

    authors: Moore K,McKnight AJ,Craig D,O'Neill F

    更新日期:2014-12-01 00:00:00

  • The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.

    abstract::Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1385/NMM:6:2-3:127

    authors: Monshausen M,Gehring NH,Kosik KS

    更新日期:2004-01-01 00:00:00

  • Attention deficit hyperactivity disorder.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine,...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1385/NMM:8:4:461

    authors: Kuntsi J,McLoughlin G,Asherson P

    更新日期:2006-01-01 00:00:00

  • The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy.

    abstract::Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase. Disease variants alter the enzyme's substrate specificity and lead to accumulation of neurotoxic 1-deoxysphingolipids. We de...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-015-8379-1

    authors: Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Schön U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

    更新日期:2016-03-01 00:00:00

  • Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia.

    abstract::There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-013-8235-0

    authors: Benvenuti S,Deledda C,Luciani P,Modi G,Bossio A,Giuliani C,Fibbi B,Peri A

    更新日期:2013-09-01 00:00:00

  • Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine.

    abstract::Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-016-8399-5

    authors: Hu S,Wang L,Mak S,Zhang Z,Xu D,Li H,Li Y,Hu Y,Lee SM,Wang Y,Han Y

    更新日期:2016-12-01 00:00:00

  • Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human superoxide dismutase (mSOD; G93A) using magnetic resonance microscopy ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章

    doi:10.1007/s12017-007-8002-1

    authors: Petrik MS,Wilson JM,Grant SC,Blackband SJ,Tabata RC,Shan X,Krieger C,Shaw CA

    更新日期:2007-01-01 00:00:00

  • Alzheimer's disease and neuronal network activity.

    abstract::The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

    journal_title:Neuromolecular medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12017-009-8100-3

    authors: Gleichmann M,Mattson MP

    更新日期:2010-03-01 00:00:00