Abstract:
:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of FD have been extensively studied and therapeutic modalities have, until recently, focused primarily on addressing the symptoms experienced by those with this fatal disorder. The primary FD-causing mutation is an intronic nucleotide substitution that alters the splicing of the IKBKAP-derived transcript. Recent efforts have resulted in the development of new therapeutic modalities that facilitate the increased production of the correctly spliced transcript and mitigate the symptoms of those with FD. Furthermore, the recent demonstration of the reduced presence of monoamine oxidase A in cells and tissues of individuals with FD has provided new insight into the cause of hypertensive crises experienced by these patients.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Rubin BY,Anderson SLdoi
10.1007/s12017-007-8019-5subject
Has Abstractpub_date
2008-01-01 00:00:00pages
148-56issue
3eissn
1535-1084issn
1559-1174journal_volume
10pub_type
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journal_title:Neuromolecular medicine
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pub_type: 杂志文章,已发布勘误
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journal_title:Neuromolecular medicine
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更新日期:2020-09-01 00:00:00
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journal_title:Neuromolecular medicine
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00