Abstract：
:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevated compared with serum from healthy controls. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-α stimulation induced the up-regulation of ROCK activity. When serum of MS patients was co-cultured with mouse cortical neurons in vitro, MS serum caused neurite shortening and reduction of cell viability, while the addition of Fasudil partially restored synaptic morphology of neurons, revealing that MS sera inhibited neurite outgrowth and synapse formation. The expression of synaptophysin was decreased in MS serum-neurons, and elevated in the presence of Fasudil. In contrast, the expression of phosphorylated collapsin response mediator protein-2 (CRMP-2) was elevated in MS serum-neurons and decreased in the presence of Fasudil. However, the addition of anti-ROCK I/II mixed antibodies in MS serum partially declined ROCK activity, but did not improve neurite outgrowth of neurons, revealing that Fasudil should prevent synaptic damage possibly through inhibiting intracellular ROCK activation mediated with MS serum. Our results indicate that axonal loss in MS may be related to increased ROCK activity. Fasudil could promote synaptogenesis and thus may contribute to preventing irreversible neurological disability associated with MS.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Chen C,Yu JZ,Zhang Q,Zhao YF,Liu CY,Li YH,Yang WF,Ma CG,Xiao BGdoi
10.1007/s12017-015-8374-6subject
Has Abstractpub_date
2015-12-01 00:00:00pages
454-65issue
4eissn
1535-1084issn
1559-1174pii
10.1007/s12017-015-8374-6journal_volume
17pub_type
杂志文章abstract：:Schizophrenia is a complex psychiatric disorder characterized by memory impairments with delusions and hallucinations. Several investigations have focused on determining the association between NOS1 (nitric oxide synthase-1) polymorphisms and risk of schizophrenia (SZ). However, the association of rs2682826, rs3782206...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s12017-017-8460-z
更新日期：2017-09-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08635-x
更新日期：2021-01-03 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:4:1-2:21
更新日期：2003-01-01 00:00:00
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journal_title：Neuromolecular medicine
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更新日期：2014-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
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journal_title：Neuromolecular medicine
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更新日期：2008-01-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-015-8379-1
更新日期：2016-03-01 00:00:00
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journal_title：Neuromolecular medicine
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,meta分析,评审
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更新日期：2015-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8415-9
更新日期：2017-03-01 00:00:00
