Abstract：
:Physical exercise has long been recognized as highly beneficial for brain and body health. The molecular mechanisms responsible for translation of exercise stimuli in the brain have claimed attention due to mounting evidence for the neuroprotective actions of the exercise and its positive effects in preventing both ageing and neurodegenerative disease. These molecular mediators are currently under investigation with new tools able to yield deep insights into the neurobiology of exercise. In the present work we focus on the evidence pertaining to the mediation of exercise effects by insulin-like growth factor 1 (IGF1), as recent reports suggest that this growth factor shows brain area-specific, temporal rank-sensitive, and behavioural task-dependent features in response to exercise.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Llorens-Martín M,Torres-Alemán I,Trejo JLdoi
10.1007/s12017-008-8026-1subject
Has Abstractpub_date
2008-01-01 00:00:00pages
99-107issue
2eissn
1535-1084issn
1559-1174journal_volume
10pub_type
杂志文章,评审abstract：:Glioma ranks first among the aggressive brain tumors all over the world. LncRNA LINC00689 has been confirmed to play key roles in the progression of cancers, and LINC00689 was upregulated in glioma. However, the biological function of LINC00689 in glioma is unclear. qRT-PCR was applied to detect the expressions of LIN...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08635-x
更新日期：2021-01-03 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. Gary S. Laco should not be listed as an author in the author group. ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12017-020-08593-4
更新日期：2020-06-01 00:00:00
abstract：:The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of metabolic and oxidative stress. Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins implicated in the regulation of mitochondrial membrane potential ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:8:3:389
更新日期：2006-01-01 00:00:00
abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-015-8378-2
更新日期：2016-03-01 00:00:00
abstract：:Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenes...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08628-w
更新日期：2020-11-09 00:00:00
abstract：:Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08624-0
更新日期：2020-11-18 00:00:00
abstract：:Hypothalamic neuropeptide Y (NPY) and superoxide dismutase (SOD) have been reported to participate in the regulation of appetite-suppressing effect of phenylpropanolamine (PPA), a sympathomimetic agent. This study explored whether Y1 receptor (Y1R) and/or Y5 receptor (Y5R) was involved in this regulation. Wistar rats ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8206-x
更新日期：2013-03-01 00:00:00
abstract：:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-cat...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:5:2:133
更新日期：2004-01-01 00:00:00
abstract：:Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using several invertebrate model systems have indicated a role for AP180 in SV recycl...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8194-x
更新日期：2013-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8402-1
更新日期：2016-09-01 00:00:00
abstract：:Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplementation of laboratory...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8414-x
更新日期：2016-09-01 00:00:00
abstract：:Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may prot...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08533-x
更新日期：2019-12-01 00:00:00
abstract：:Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8399-5
更新日期：2016-12-01 00:00:00
abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8034-1
更新日期：2008-01-01 00:00:00
abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8022-5
更新日期：2008-01-01 00:00:00
abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-019-08589-9
更新日期：2020-12-01 00:00:00
abstract：:Selective degeneration and death of motor neurons in SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) is accompanied by axonal disorganization and reduced slow axonal transport in the three most frequently used mouse models of mutant SOD1-mediated ALS. To test whether suppression of axonal degeneration (freque...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:5:3:193
更新日期：2004-01-01 00:00:00
abstract：:The present study demonstrates the efficacies of synthetic 1,8-cineole and an 1,8-cineole-rich supercritical carbon dioxide (SC-CO2) extract of small cardamom seeds in preventing oligomerization of amyloid beta peptide (Aβ42) and inhibiting iron-dependent oxyradical production in vitro. The oligomerization of Aβ42 was...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08574-2
更新日期：2020-03-01 00:00:00
abstract：:Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/nmm:9:1:1
更新日期：2007-01-01 00:00:00
abstract：:Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with fir...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-018-8485-y
更新日期：2018-06-01 00:00:00
abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-008-8041-2
更新日期：2008-01-01 00:00:00
abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-007-8019-5
更新日期：2008-01-01 00:00:00
abstract：:Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine,...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:8:4:461
更新日期：2006-01-01 00:00:00
abstract：:Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autop...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8275-5
更新日期：2014-06-01 00:00:00
abstract：:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevate...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-015-8374-6
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08582-2
更新日期：2020-06-01 00:00:00
abstract：:The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8394-x
更新日期：2016-09-01 00:00:00
abstract：:Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophil proteinase 3), and from many other cell types (e.g., trypsins) can specifically signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled recepto...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:7:1-2:079
更新日期：2005-01-01 00:00:00
abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8212-z
更新日期：2013-03-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human superoxide dismutase (mSOD; G93A) using magnetic resonance microscopy ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-007-8002-1
更新日期：2007-01-01 00:00:00
