Abstract:
:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-catenins, it inhibits Wnt signaling and is therefore also a functional candidate. We initially genotyped two single-nucleotide polymorphisms (SNPs) in the gene, in four independent samples comprising over 1200 cases and controls but failed to detect an association with either SNP. Similarly, we found no evidence for association between CTNNA3 and AD in a sample of subjects showing linkage to chromosome 10, nor were these SNPs associated with Abeta deposition in brain. To comprehensively screen the gene, we genotyped 30 additional SNPs in a subset of the cases and controls (n > 700). None of these SNPs was associated with disease. Although an excellent candidate, we conclude that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Busby V,Goossens S,Nowotny P,Hamilton G,Smemo S,Harold D,Turic D,Jehu L,Myers A,Womick M,Woo D,Compton D,Doil LM,Tacey KM,Lau KF,Al-Saraj S,Killick R,Pickering-Brown S,Moore P,Hollingworth P,Archer N,Foy C,Waldoi
10.1385/NMM:5:2:133keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
133-46issue
2eissn
1535-1084issn
1559-1174pii
NMM:5:2:133journal_volume
5pub_type
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