Synaptogenesis: Modulation by Availability of Membrane Phospholipid Precursors.

abstract：:Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusio...

journal_title：Neuromolecular medicine

authors： Yue Y,Zhao H,Yue Y,Zhang Y,Wei W

更新日期：2020-09-01 00:00:00

abstract：:Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with fir...

journal_title：Neuromolecular medicine

authors： Ye Z,Zhang H,Sun L,Cai H,Hao Y,Xu Z,Zhang Z,Liu X

更新日期：2018-06-01 00:00:00

abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

journal_title：Neuromolecular medicine

authors： Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

更新日期：2016-03-01 00:00:00

abstract：:A major component of green tea, a widely consumed beverage, is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. Our previous study has indicated that free radical production following rat traumatic brain injury (TBI) induces neural degeneration. In this study, we investigated the effects o...

journal_title：Neuromolecular medicine

authors： Itoh T,Imano M,Nishida S,Tsubaki M,Hashimoto S,Ito A,Satou T

更新日期：2011-12-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors...

journal_title：Neuromolecular medicine

authors： Cole NB,Murphy DD

更新日期：2002-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human superoxide dismutase (mSOD; G93A) using magnetic resonance microscopy ...

journal_title：Neuromolecular medicine

authors： Petrik MS,Wilson JM,Grant SC,Blackband SJ,Tabata RC,Shan X,Krieger C,Shaw CA

更新日期：2007-01-01 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine,...

journal_title：Neuromolecular medicine

authors： Kuntsi J,McLoughlin G,Asherson P

更新日期：2006-01-01 00:00:00

abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...

journal_title：Neuromolecular medicine

authors： Kaye DM,Esler MD

更新日期：2008-01-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00

abstract：:Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase. Disease variants alter the enzyme's substrate specificity and lead to accumulation of neurotoxic 1-deoxysphingolipids. We de...

journal_title：Neuromolecular medicine

authors： Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Schön U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

更新日期：2016-03-01 00:00:00

abstract：:Neurons and especially their synapses often project long thin processes that can invaginate neighboring neuronal or glial cells. These "invaginating projections" can occur in almost any combination of postsynaptic, presynaptic, and glial processes. Invaginating projections provide a precise mechanism for one neuron to...

journal_title：Neuromolecular medicine

authors： Petralia RS,Wang YX,Mattson MP,Yao PJ

更新日期：2015-09-01 00:00:00

abstract：:Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular...

journal_title：Neuromolecular medicine

authors： Easwaran TP,Lancki N,Henriquez M,Vortmeyer AO,Barbaro NM,Scholtens DM,Ahmed AU,Dey M

更新日期：2020-11-18 00:00:00

abstract：:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...

journal_title：Neuromolecular medicine

authors： Monshausen M,Gehring NH,Kosik KS

更新日期：2004-01-01 00:00:00

abstract：:The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of metabolic and oxidative stress. Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins implicated in the regulation of mitochondrial membrane potential ...

journal_title：Neuromolecular medicine

authors： Liu D,Chan SL,de Souza-Pinto NC,Slevin JR,Wersto RP,Zhan M,Mustafa K,de Cabo R,Mattson MP

更新日期：2006-01-01 00:00:00

abstract：:Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may prot...

journal_title：Neuromolecular medicine

authors： Pianta S,Lee JY,Tuazon JP,Castelli V,Mantohac LM,Tajiri N,Borlongan CV

更新日期：2019-12-01 00:00:00

abstract：:The present study demonstrates the efficacies of synthetic 1,8-cineole and an 1,8-cineole-rich supercritical carbon dioxide (SC-CO2) extract of small cardamom seeds in preventing oligomerization of amyloid beta peptide (Aβ42) and inhibiting iron-dependent oxyradical production in vitro. The oligomerization of Aβ42 was...

journal_title：Neuromolecular medicine

authors： Paul K,Ganguly U,Chakrabarti S,Bhattacharjee P

更新日期：2020-03-01 00:00:00

abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...

journal_title：Neuromolecular medicine

authors： Shinkai T,De Luca V,Utsunomiya K,Sakata S,Inoue Y,Fukunaka Y,Hwang R,Ohmori O,Kennedy JL,Nakamura J

更新日期：2008-01-01 00:00:00

abstract：:Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor sympto...

journal_title：Neuromolecular medicine

authors： Sanjari Moghaddam H,Valitabar Z,Ashraf-Ganjouei A,Mojtahed Zadeh M,Ghazi Sherbaf F,Aarabi MH

更新日期：2018-09-01 00:00:00

abstract：:Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia. It is due to mutations in Pantothenate Kinase 2 (PANK2), an enzyme that catalyzes the phosphorylation of vitamin B5, first and essential step in coenz...

journal_title：Neuromolecular medicine

authors： Khatri D,Zizioli D,Trivedi A,Borsani G,Monti E,Finazzi D

更新日期：2019-06-01 00:00:00

abstract：:Abnormal interactions and misfolding of synaptic proteins in the nervous system are being extensively explored as important pathogenic events resulting in neurodegeneration in various neurological disorders. These include Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). In AD, m...

journal_title：Neuromolecular medicine

authors： Hashimoto M,Rockenstein E,Crews L,Masliah E

更新日期：2003-01-01 00:00:00

abstract：:GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the ei...

journal_title：Neuromolecular medicine

authors： Yu W,Liang S,Zhang C

更新日期：2018-12-01 00:00:00

abstract：:T-cells directed to self-antigens ("autoimmune" T-cells) have traditionally been perceived as tending to attack the body's own tissues, and likely to exert their destructive effects unless they undergo deletion in the thymus during ontogeny. Naturally occurring CD4+CD25+ regulatory T-cells were viewed as thymus-derive...

journal_title：Neuromolecular medicine

authors： Kipnis J,Schwartz M

更新日期：2005-01-01 00:00:00

abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

journal_title：Neuromolecular medicine

authors： Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

更新日期：2016-09-01 00:00:00

abstract：:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D ...

journal_title：Neuromolecular medicine

authors： Gezen-Ak D,Alaylıoğlu M,Genç G,Gündüz A,Candaş E,Bilgiç B,Atasoy İL,Apaydın H,Kızıltan G,Gürvit H,Hanağası H,Ertan S,Yılmazer S,Dursun E

更新日期：2017-03-01 00:00:00

abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

journal_title：Neuromolecular medicine

authors： Gleichmann M,Mattson MP

更新日期：2010-03-01 00:00:00

abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...

journal_title：Neuromolecular medicine

authors： Shy ME

更新日期：2006-01-01 00:00:00

abstract：:Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout...

journal_title：Neuromolecular medicine

authors： Bampi GB,Bisso-Machado R,Hünemeier T,Gheno TC,Furtado GV,Veliz-Otani D,Cornejo-Olivas M,Mazzeti P,Bortolini MC,Jardim LB,Saraiva-Pereira ML,Rede Neurogenetica.

更新日期：2017-12-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00

abstract：:The α-synuclein gene (SNCA) plays a major role in the aetiology of Lewy body disease (LBD) including Parkinson's disease (PD). Point mutations and genetic alterations causing elevated gene expression are causally linked to familial PD. To what extent epigenetic changes play a role in the regulation of α-synuclein expr...

journal_title：Neuromolecular medicine

authors： de Boni L,Tierling S,Roeber S,Walter J,Giese A,Kretzschmar HA

更新日期：2011-12-01 00:00:00

abstract：:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevate...

journal_title：Neuromolecular medicine

authors： Chen C,Yu JZ,Zhang Q,Zhao YF,Liu CY,Li YH,Yang WF,Ma CG,Xiao BG

更新日期：2015-12-01 00:00:00