Abstract:
:The α-synuclein gene (SNCA) plays a major role in the aetiology of Lewy body disease (LBD) including Parkinson's disease (PD). Point mutations and genetic alterations causing elevated gene expression are causally linked to familial PD. To what extent epigenetic changes play a role in the regulation of α-synuclein expression and may contribute to the aetiology of sporadic LBD is a matter of debate. We analysed the methylation state of the promoter region and a CpG-rich region of intron 1 of α-synuclein in several brain regions in sporadic LBD and controls using 454 GS-FLX-based high-resolution bisulphite sequencing. Our results indicate that there are significant differences in the level of methylation between different brain areas. The overall methylation levels in the promoter and intron 1 of α-synuclein are rather low in controls and-in contrast to previously reported findings-are not significantly different from LBD. However, single CpG analysis revealed significant hyper- and hypomethylation at different positions in various brain regions and LBD stages. A slight overall increase in methylation related to LBD patients' age was detected.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
de Boni L,Tierling S,Roeber S,Walter J,Giese A,Kretzschmar HAdoi
10.1007/s12017-011-8163-9subject
Has Abstractpub_date
2011-12-01 00:00:00pages
310-20issue
4eissn
1535-1084issn
1559-1174journal_volume
13pub_type
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