Abstract:
:Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular classification of gliomas is associated with preoperative seizure presentation and/or post-operative seizure control across multiple glioma subtypes. All gliomas operated at our institution from 2007 to 2017 were identified based on ICD 9 and 10 billing codes and were retrospectively assessed for molecular classification of the IDH1 mutation, and 1p/19q codeletion. Logistic regression models were performed to assess associations of seizures at presentation as well as post-operative seizures with IDH status and the new WHO integrated classification. Our study included 376 patients: 82 IDH mutant and 294 IDH wildtype. The presence of IDH mutation was associated with seizures at presentation [OR 3.135 (1.818-5.404), p < 0.001]. IDH-mutant glioblastomas presented with seizures less often than other IDH-mutant glioma subtypes grade II and III [OR 0.104 (0.032-0.340), p < 0.001]. IDH-mutant tumors were associated with worse post-operative seizure outcomes, demonstrated by Engel Class [OR 2.666 (1.592-4.464), p < 0.001]. IDH mutation in gliomas is associated with an increased risk of seizure development and worse post-operative seizure control, in all grades except for GBM.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Easwaran TP,Lancki N,Henriquez M,Vortmeyer AO,Barbaro NM,Scholtens DM,Ahmed AU,Dey Mdoi
10.1007/s12017-020-08624-0subject
Has Abstractpub_date
2020-11-18 00:00:00eissn
1535-1084issn
1559-1174pii
10.1007/s12017-020-08624-0pub_type
杂志文章abstract::Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...
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journal_title:Neuromolecular medicine
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journal_title:Neuromolecular medicine
pub_type: 杂志文章
doi:10.1385/nmm:8:1-2:255
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journal_title:Neuromolecular medicine
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Neuromolecular medicine
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