Abstract：
:Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autophagy, a mechanism by which aggregates of misfolded proteins are cleared by the cell. In this work, we expressed the pathogenic N-terminal fragment of huntingtin in Δnth1 mutant (unable to degrade trehalose) of Saccharomyces cerevisiae BY4742 strain. We show that the presence of trehalose resulted in the partitioning of the mutant huntingtin in the soluble fraction of the cell. This led to reduced oxidative stress and improved cell survival. The beneficial effect was independent of the expression of the major cellular antioxidant enzyme, superoxide dismutase. Additionally, trehalose led to the overexpression of the heat shock protein, Hsp104p, in mutant huntingtin-expressing cells, and resulted in rescue of the endocytotic defect in the yeast cell. We propose that at least in the initial stages of aggregation, trehalose functions as a stabiliser, increasing the level of monomeric mutant huntingtin protein, with its concomitant beneficial effects, in addition to its role as an inducer of autophagy.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Chaudhary RK,Kardani J,Singh K,Banerjee R,Roy Idoi
10.1007/s12017-013-8275-5subject
Has Abstractpub_date
2014-06-01 00:00:00pages
280-91issue
2eissn
1535-1084issn
1559-1174journal_volume
16pub_type
杂志文章abstract：:We have previously reported that mild traumatic brain injury (mTBI) induced cognitive deficits as well as apoptotic changes in the brains of mice. Apoptosis may be caused by severe, prolonged accumulation of misfolded proteins, and protein aggregation in the endoplasmic reticulum (ER stress). In an additional study, w...
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pub_type： 杂志文章
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8393-y
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8044-z
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更新日期：2014-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1385/NMM:1:2:95
更新日期：2002-01-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-014-8332-8
更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-11-12 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12017-020-08593-4
更新日期：2020-06-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8415-9
更新日期：2017-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-014-8321-y
更新日期：2014-12-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 传,历史文章,杂志文章
doi：10.1007/s12017-010-8124-8
更新日期：2011-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:8:4:461
更新日期：2006-01-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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更新日期：2013-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08574-2
更新日期：2020-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-018-8506-x
更新日期：2018-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:1:3:183
更新日期：2002-01-01 00:00:00
abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8219-0
更新日期：2013-06-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8403-0
更新日期：2016-09-01 00:00:00
abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/nmm:8:1-2:255
更新日期：2006-01-01 00:00:00
