Abstract:
:Cyclin H regulates cell cycle transitions; it always forms trimeric cyclin-dependent protein kinases (CDK)-activating kinase (CAK) complex with CDK7 and MAT1 that phosphorylates a threonine residue in the CDK2 T loop region. However, neither the expression nor function of cyclin H in the central nervous system (CNS) injury is still clear. Therefore, we studied cyclin H in a rat spinal cord contusion model. Injury markedly increased cyclin H protein expression throughout the thoracic spinal cord but did not increase CDK7. However, double immunofluorescent staining for proliferating cell nuclear antigen (PCNA) and cell markers revealed increases of cyclin H and CDK2 in proliferating microglia and astrocytes, and the co-immunoprecipitation studies shown that the associations of cyclin H with CDK2 were enhanced evidently after injury. Our data suggest that cyclin H may play a proliferative role in spinal cord injury (SCI).
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Wu G,Cao J,Peng C,Yang H,Cui Z,Zhao J,Wu Q,Han J,Li H,Gu X,Zhang Fdoi
10.1007/s12017-011-8150-1subject
Has Abstractpub_date
2011-09-01 00:00:00pages
187-96issue
3eissn
1535-1084issn
1559-1174journal_volume
13pub_type
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