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Efficacy of second-line erlotinib in patients postprogression of first-line chemotherapy in head and neck cancers.

Abstract：

BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treatment in Head and neck cancers. METHODS:This was a post-hoc retrospective analysis of a randomized study comparing metronomic chemotherapy with cisplatin. A patient who progressed on chemotherapy and had a PS0-2 were offered second-line chemotherapy. Patients who had received erlotinib (150 mg PO OD) as second line treatment were selected for this analysis. Erlotinib was discontinued in case of either progression of disease or if the patient had intolerable side effects. Patient were monitored 1-week after the start of erlotinib and subsequently at monthly intervals. The toxicity was recorded in accordance with CTCAE version 4.02 (NCI,USA) and the response were graded in accordance with RECIST version 1.1. All of these patients were followed-up till death. RESULTS:Twenty-three patients were identified. The median age of these patients at the start of the second line was 47 years (interquartile range 40.5-51.75 years). The primary site of distribution was oral cavity primary in 17 patients (77.3%) and nonoral cavity primary in 05 (22.7%) patients. The immediate last chemotherapy regimen received was cisplatin in 9 patients (40.9%) and metronomic chemotherapy in 13 patients (59.1%). Symptomatic benefits post second-line erlotinib was seen in 18 patients (81.8%). The most common adverse events (any grade) seen were anemia in 20 patients (90.9%), rash in 10 patients (45.5%) and diarrhea in 7 patients (31.8%).The best radiological response documented were a partial response in 04 patients (19.2%). The median estimated PFS and OS were 110 days (95% confidence interval [CI]: 61-175 days) and 156 days (95% CI: 126-185 days) respectively. CONCLUSION:Erlotinib single agent has promising activity in the second line and needs to be explored in future studies.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Patil V,Karpe A,Noronha V,Joshi A,Muddu V,Bhattacharjee A,Dhumal S,Prabhash K

doi

10.4103/0019-509X.178374

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

629-31

issue

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2015_52_4_629_178374

journal_volume

pub_type

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Efficacy of second-line erlotinib in patients postprogression of first-line chemotherapy in head and neck cancers.