Abstract：
INTRODUCTION:Second primary malignancy (SPM) is associated with decreased overall survival (OS) in laryngeal carcinomas (LC). METHODS:One hundred eighty three LC patients were analyzed retrospectively. The primary and secondary endpoints were the incidence of SPM and the OS difference between patients with and without SPM. RESULTS:SPM developed in 22 (12.0%) patients at median 52 months (range, 4-131 months), with a yearly 2.8% incidence, of which 19 (10.4%) and 3 (1.6%) were metachronous and synchronous, respectively. Lung was the commonest SPM (72.7%). Of 47 deaths, 12 (25.5%) were SPM related. Comparatively SPM patients had significantly shorter median OS (68.0 months vs. median not reached; P = 0.005), with lower 5-year (67.0% vs. 78.9%) and 8-year (32.6 vs. 69.8%) survival rates. CONCLUSION:The present findings suggested the SPM as a competing risk factor for death in index LC patients with its annual incidence rate of 2.8% and for accounting one of every four deaths in this patients group. Emergence of lung carcinoma as the most frequent type of SPM and the ability to treat >50% of them with an estimated long-term outcomes emphasizes the importance of early diagnosis and curative treatment of SPMs.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Ozdemir Y,Topkan Edoi
10.4103/ijc.IJC_273_18subject
Has Abstractpub_date
2019-01-01 00:00:00pages
29-34issue
1eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2019_56_1_29_255479journal_volume
56pub_type
杂志文章abstract：:Treatment of cancer is limited by affordability of patients in the many developing countries including India. Generic drug manufacturers have responded to this scenario by making drugs available at affordable costs, often at less than 10% the cost of the original brand. In our practice, it is found that there is a thr...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146723
更新日期：2014-07-01 00:00:00
abstract：:Primary undifferentiated embryonal of the liver in children is a rare neoplasm with dismal prognosis. Surgery is the treatment of choice. Adjuvant chemotherapy may prove useful in improving the prognosis of these tumours. We report two cases of Primary undifferentiated embryonal sarcoma of the liver. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Recent studies indicate neoadjuvant chemotherapy (NACT) can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF) NACT in our setting is lacking. The pr...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134649
更新日期：2014-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175827
更新日期：2015-04-01 00:00:00
abstract：Background:Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL). Methods:In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived inducti...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_110_19
更新日期：2021-01-06 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118732
更新日期：2013-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.73572
更新日期：2010-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_517_17
更新日期：2018-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.15098
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_115_18
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_155_17
更新日期：2017-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.4103/0019-509x.29424
更新日期：2006-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_542_18
更新日期：2020-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175321
更新日期：2014-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_499_17
更新日期：2017-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146728
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journal_title：Indian journal of cancer
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doi：
更新日期：1996-09-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175569
更新日期：2015-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82875
更新日期：2011-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
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journal_title：Indian journal of cancer
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更新日期：2017-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
