Abstract：
Background:Ki-67 index is an important prognostic marker in breast cancer and is also used to differentiate luminal A subtype from luminal B. Inter-observer variations in determining the index and the cut-off value to be considered in distinguishing the two subtypes remain problems in clinical practice. Methods:MIB-1 immunohistochemistry was done on 200 cases of breast cancer with 50 cases in each molecular subtype. The Ki-67 scoring was done manually by two observers and automated method (using the software ImmunoRatio). The mean value of Ki-67 was calculated in each molecular group and in the entire estrogen receptor and progesterone receptor (ER/PR) positive group. The inter-observer variability between the two observers and the automated method was also assessed. Results:The mean and median values of Ki-67 of all the 200 cases obtained by manual scoring was 31.13% and 29.65% by observer 1, 28.48% and 27.90% by observer 2, and 38.27% and 35.45% by the automated method. The mean Ki-67 value obtained by manual scoring, in luminal A, luminal B, HER2 enriched and triple negative was 21.07%, 37.19%, 33.72% and 27.27%, respectively. There was significant correlation between the two observers and with the automated scoring.. The mean value of the Ki-67 index in the ER/PR positive group was 29.1%. Conclusion:The inter-observer correlation and the correlation with the automated scoring system of the Ki-67 index was good. 29.1% was the mean Ki-67 index in the ER/PR positive group and this value was within the acceptable range as per St Galen's recommendation.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Meermira D,Swain M,Gowrishankar Sdoi
10.4103/ijc.IJC_719_18subject
Has Abstractpub_date
2020-07-01 00:00:00pages
289-295issue
3eissn
0019-509Xissn
1998-4774pii
290552journal_volume
57pub_type
杂志文章abstract：OBJECTIVE:The aim of the present study was to evaluate the efficacy and safety of pemetrexed chemotherapy combined with intrapleural injection of pemetrexed and bevacizumab in the treatment of malignant pleural mesothelioma (MPM)-mediated malignant pleural effusion, and analyze the objective response rate (ORR), the me...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.154058
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197726
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.172519
更新日期：2015-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.55550
更新日期：2009-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1992-09-01 00:00:00
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.27934
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Indian journal of cancer
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更新日期：2017-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151999
更新日期：2015-02-01 00:00:00
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journal_title：Indian journal of cancer
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doi：10.4103/0019-509X.118725
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journal_title：Indian journal of cancer
pub_type： 杂志文章,随机对照试验
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更新日期：2017-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151994
更新日期：2015-02-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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更新日期：2015-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176715
更新日期：2015-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_73_18
更新日期：2018-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.73572
更新日期：2010-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
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journal_title：Indian journal of cancer
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doi：
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Indian journal of cancer
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更新日期：2014-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
