Abstract:
BACKGROUND:Infections are the most important cause of mortality in patients with high-risk febrile neutropenia. Emergence of multi-drug resistant organisms (MDROs) has become a major challenge for hemato-oncologists. Knowledge of the prevalent organisms and their antimicrobial sensitivity can help deciding the empirical therapy at individual centers and allows timely measures to reduce the risk of antimicrobial resistance. AIMS:To evaluate the frequency of bacterial isolates from all the samples and the pattern of bacterial bloodstream infections and incidence of MDROs. SETTINGS AND DESIGN:This is a retrospective analysis from a tertiary care cancer center. MATERIALS AND METHODS:From January to June 2014 information on all the samples received in Department of Microbiology was collected retrospectively. The data from samples collected from patients with hematological cancers were analyzed for types of bacterial isolates and antimicrobial sensitivity. RESULTS:A total of 739 isolates were identified with 67.9% of isolates being Gram-negative. The predominant Gram-negative organisms were Escherichia coli, Psuedomonas spp. and Klebsiella spp. Among the bacterial bloodstream infections, 66% were Gram-negative isolates. MDROs constituted 22% of all isolates in blood cultures. Incidence of resistant Gram-positive organisms was low in the present dataset (methicillin resistant Staphylococcus aureus and vancomycin-resistant enterococci-1.3%). CONCLUSIONS:The analysis reconfirms the Gram-negative organisms as the predominant pathogens in bacteremia seen in patients with hematological cancers. The high frequency of multi-drug resistance in the dataset calls for the need of emergency measures to curtail further development and propagation of resistant organisms.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Sengar M,Kelkar R,Jain H,Biswas S,Pawaskar P,Karpe Adoi
10.4103/0019-509X.175387subject
Has Abstractpub_date
2014-10-01 00:00:00pages
456-8issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2014_51_4_456_175387journal_volume
51pub_type
杂志文章abstract:Background:Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL). Methods:In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived inducti...
journal_title:Indian journal of cancer
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doi:10.4103/ijc.IJC_110_19
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abstract::Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, the...
journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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abstract::Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...
journal_title:Indian journal of cancer
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abstract::Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
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abstract::Prostate cancer is one of the most common malignancies of elderly males. Management depends on the accurate estimation of disease both at initial diagnosis and in its subsequent course. In the present study, we evaluated the diagnostic utility of positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) in p...
journal_title:Indian journal of cancer
pub_type: 杂志文章
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abstract::Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...
journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
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journal_title:Indian journal of cancer
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doi:
更新日期:1999-06-01 00:00:00
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journal_title:Indian journal of cancer
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doi:10.4103/ijc.IJC_239_17
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.200669
更新日期:2016-07-01 00:00:00
abstract::Wide resection of bone tumour has become an accepted treatment in the limb salvage surgery. The reconstruction of the residual defect following wide resection is a major problem. The motions of involved joint after resection of the large tumour can be restored by using either the osteoarticular allograft or endoprosth...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
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更新日期:2006-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00