Abstract：
:Radiotherapy forms one of the major treatment modalities for head and neck cancers (HNC), and precision radiotherapy techniques, such as intensity-modulated radiotherapy require accurate target delineation to ensure success of the treatment. Conventionally used imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging are used to delineate the tumor. Imaging, such as positron emission tomography (PET)-CT, which combines the functional and anatomic modalities, is increasingly being used in the management of HNC. Currently, 18-fluorodeoxyglucose is the most commonly used radioisotope, which is accumulated in areas of high glucose uptake, such as the tumor tissue. Because most disease recurrences are within the high-dose radiotherapy volume, defining a biological target volume for radiotherapy boost is an attractive approach to improve the results. There are many challenges in employing the PET-CT for radiotherapy planning, such as patient positioning, target edge definition, and use of new PET tracers, which represent various functional properties, such as hypoxia, protein synthesis, and proliferation. The role of PET-CT for radiotherapy planning is ever expanding and more clinical data underlining the advantages and challenges in this approach are emerging. In this article, we review the current clinical evidence for the application of functional imaging to radiotherapy planning and discuss some of the current challenges and possible solutions that have been suggested to date.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Dandekar P,Partridge M,Kazi R,Nutting C,Harrington K,Newbold Kdoi
10.4103/0019-509X.64717subject
Has Abstractpub_date
2010-07-01 00:00:00pages
260-6issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2010_47_3_260_64717journal_volume
47pub_type
杂志文章,评审abstract：AIMS:The aim of this study is to investigate the activity and toxicity of etoposide with AUC 6 doses of carboplatin in patients with previously untreated extensive disease - small-cell lung cancer (SCLC). MATERIALS AND METHODS:88 eligible patients were treated with chemotherapy comprised of carboplatin AUC of 6, IV da...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.92279
更新日期：2011-10-01 00:00:00
abstract：PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions o...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：INTRODUCTION:Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulf...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_349_17
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.104499
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Metaplastic breast carcinoma (MBC) is a rare disease with incidence of less than 1%. MBC present with a larger tumor size, less number of nodes involved, mostly undifferentiated triple negative tumors. We aimed to determine progression-free and overall survival and reported hospital-based incidence of MBC. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_731_18
更新日期：2019-04-01 00:00:00
abstract：:The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaem...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146774
更新日期：2014-07-01 00:00:00
abstract：:Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197726
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Seroma formation after mastectomy typically delays recovery and adds to morbidity. AIMS:This retrospective review was undertaken to identify factors which predict development of seroma after mastectomy for breast cancer patients. SETTING AND DESIGN:119 consecutive patients intended for mastectomy for the t...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.38940
更新日期：2007-07-01 00:00:00
abstract：:Adjuvant treatment in gastric adenocarcinoma has been a challenge for the treating specialists, and despite several trials, a clear consensus is yet to be defined. The higher propensity for lymph nodal involvement and locoregional recurrences led to the hypothesis that locoregional and systemic treatments need to be e...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_375_18
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The three direct factors that could lead cancer patients to anemia, apart from therapy are iron deficiency, inflammatory cytokines surge and decreased erythropoietin (Epo). Our aim was to quantify biochemical and hematologic markers serum Epo, ferritin (Fe) and tumor necrosis factor-alpha (TNF-α) along with ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175579
更新日期：2015-01-01 00:00:00
abstract：CONTEXT:The most commonly prescribed conventional fractionation radiotherapy uses 1.8-2.2 Gy per fraction for five fractions in a week. Many times, unwanted interruptions are encountered, which ultimately affect the local control and overall survival. AIMS:The present retrospective study was carried out to study the c...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_517_17
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:We aimed to study the compliance and treatment outcome of patients who received adjuvant treatment following curative resection for periampullary cancers periampullary cancers. MATERIALS AND METHODS:Institute medical records of PAC treated during 2007-2014 were retrieved. Demographics, treatment, and outcom...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_358_17
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Globally tobacco epidemic kills nearly six million people annually. Consumption of tobacco products is on the rise in low- and middle-income countries. Tobacco is addictive; hence, tobacco users need support in quitting. AIMS:Providing tobacco cessation services to women in community enabling them to quit t...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.147474
更新日期：2014-12-01 00:00:00
abstract：:Wide resection of bone tumour has become an accepted treatment in the limb salvage surgery. The reconstruction of the residual defect following wide resection is a major problem. The motions of involved joint after resection of the large tumour can be restored by using either the osteoarticular allograft or endoprosth...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:Twenty-two histologically confirmed cases of Clear Cell Sarcomas (C.C.S.) seen over a sixteen year period, are retrospectively analysed from a clinico-pathological view-point. The tumours occurred in young adults, average 36 years. Males predominated, and the lower extremity particularly the thigh and foot were the mo...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:Five cases of primary lymphoma of the brain are reported and the literature reviewed. The diverse clinical spectrum at presentation and variable response to therapy are few of its unique features. The literature is reviewed briefly and the importance of diagnosis at an early stage and prompt institution of therapy in ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：:Treatment of cancer is limited by affordability of patients in the many developing countries including India. Generic drug manufacturers have responded to this scenario by making drugs available at affordable costs, often at less than 10% the cost of the original brand. In our practice, it is found that there is a thr...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146723
更新日期：2014-07-01 00:00:00
abstract：:Scrambler therapy (ST) is a novel noninvasive modality for treatment of chronic neuropathic and cancer pain using 5 artificial neurons. The principle with Scrambler Therapy is that synthetic "non-pain" information is transmitted by C fiber surface receptors. Chemotherapy-induced peripheral neuropathy can markedly dete...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_361_18
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.4103/ijc.IJC_174_17
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:This study was undertaken to evaluate the clinicopathological characteristics of patients with breast cancer at our institute, a tertiary-care cancer center in northern India. MATERIALS AND METHODS:This retrospective study included all patients with breast cancer registered at our institute from January 1...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_73_18
更新日期：2018-07-01 00:00:00
abstract：Background:Despite the advances in screening during the past decades, colorectal cancer (CRC) still is a leading cause of cancer deaths worldwide. Therefore, the development of new diagnostic methods is necessary. Aim:The aim of this study was to compare methylation changes of SRY-Box 21 (SOX21) gene promoter in tumor...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_542_18
更新日期：2020-04-01 00:00:00
abstract：:A case of low grade hemangiopericytoma of three years duration occurring in the upper end of the femur of a 70 year old man is described. Radiologically, the upper third of the right femur showed a destructive expansile osteolytic lesion with soft tissue extension. The tumour was partially encapsulated. Mitoses were 0...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_260_18
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:This study aimed to evaluate the outcome of benign vocal cord tumors treated using a laryngeal endoscopy under low temperature-controlled radiofrequency and to elucidate the application of a dynamic laryngoendoscopy in the operation. MATERIALS AND METHODS:85 patients with benign vocal cord tumors were treate...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151994
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:5-Fluorouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the r...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：10.4103/0019-509X.75816
更新日期：2011-01-01 00:00:00
abstract：:In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the ce...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.172519
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.15098
更新日期：2005-01-01 00:00:00
