Abstract：
:Treatment of cancer is limited by affordability of patients in the many developing countries including India. Generic drug manufacturers have responded to this scenario by making drugs available at affordable costs, often at less than 10% the cost of the original brand. In our practice, it is found that there is a three-fold higher prescription of generic brands compared to innovator, accompanied by cost savings of up to 80% per prescription. Unfortunately, the regulatory environment prevailing in India is not geared to ensure satisfactory quality of generic products. The standards set by the regulatory agencies for establishing equivalence of generics vis-ΰ-vis the innovator product allow anticancer generics to enter markets without undergoing clinical evaluation. Many drug manufacturing units in India flout good manufacturing practice norms, which was evident during the center for drug evaluation and research classifications inspection in the year 2006. Inferior drugs have therefore, made their way into the Indian markets, compromising the quality of care. The system of drug manufacturing and marketing approval needs a major overhaul, including regular inspection of manufacturing facilities. Bioequivalence should be made mandatory for all oral formulations. Unless these measures are rigidly implemented, the benefits of generic substitution would be seriously undermined.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Gota VS,Patial Pdoi
10.4103/0019-509X.146723subject
Has Abstractpub_date
2014-07-01 00:00:00pages
366-368issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2014_51_3_366_146723journal_volume
51pub_type
杂志文章abstract：BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
abstract：:A rare case of pleomorphic intimal sarcoma of pulmonary trunk is reported. The patient presented with symptoms of right ventricular out flow tract (RVOT) obstruction. Metastatic deposits were seen in lungs, diaphragm and thyroid. Bronchial mucosal involvement was also seen. The tumour showed multicentric origin and on...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This st...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_737_18
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Invasion and metastasis are the most strenuous problems in the management of breast cancer. These events require diverse proteolytic enzymes, among which MMP-2 and MMP-9 play a significant role in degradation of type IV collagen, the major component of the basement membrane. Therefore, the major objective of...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.52953
更新日期：2009-07-01 00:00:00
abstract：:A rare morphological variant of acute lymphoblastic leukaemia in a ten years old child is described. Ninety five percent of the lymphoblasts had significant number of course granules in the cytoplasm. Diagnostic and prognostic significance of this variant is discussed. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:The product of Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.55550
更新日期：2009-10-01 00:00:00
abstract：:Activating mutations in the epidermal growth factor receptor gene and rearrangement of the anaplastic lymphoma kinase gene exemplify the molecular characterization of nonsmall cell lung cancer (NSCLC), particularly adenocarcinoma, and its therapeutic relevance. Several genetic alterations with prognostic and predictiv...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_258_17
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treat...
journal_title：Indian journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.4103/0019-509X.178374
更新日期：2015-10-01 00:00:00
abstract：:In the cervical cancer cases registered at the Cancer Hospital at Barshi, India during 1988-90, 99 of the 105 cases were clinically staged (Total number of cases registered: 136). The annual number of cases were too few for a comparison of stage distribution between the registry years. However, comparison of the propo...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Twenty five patients of advanced breast cancer (Stage IIIb and IV) were studied and the histological changes following chemotherapy were looked. All the tumours showed varying degree of histological changes. Twenty eight percent tumours showed Grade I changes, 28 percent had Grade II changes and 28 percent had Grade I...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:In our study, we have treated cases of early glottic carcinoma by two different dose-fractionation schedules in relation to overall treatment time. MATERIALS AND METHODS:This is an analysis of 29 patients with invasive, previously untreated T1and T2squamous cell carcinoma of true vocal cord that was treat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200677
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.25773
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC. PATIENTS AND METHODS:The ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176736
更新日期：2015-07-01 00:00:00
abstract：:Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175805
更新日期：2015-04-01 00:00:00
abstract：:Positron emission tomography (PET) has emerged as an important diagnostic tool in the management of lung cancers. Although PET is sensitive in detection of lung cancer, but FDG (2-deoxy-2- 18 fluro-D-glucose) is not tumor specific and may accumulate in a variety of nonmalignant conditions occasionally giving false pos...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509x.44660
更新日期：2008-10-01 00:00:00
abstract：:The practice of radiation oncology requires stringent adherence to specific steps and principles designed to minimize exposure of an individual to unnecessary doses of radiation. The basic principles of such measures to reduce the risk of exposure and limit the doses of irradiation follow the "as low as reasonably ach...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_343_20
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) derived from Plumbago species is a potential anti-tumour agent. Plumbagin has been tested for anti-cancer activity in vitro and in vivo using mice model. AIM:To study the tumour suppressing efficacy of plumbagin using zebrafish model. MATERIALS AND METHODS:H...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.219580
更新日期：2017-01-01 00:00:00
abstract：:Cytogenetic analysis using G-banding techniques for the diagnosis of malignancy in pleural and peritoneal effusions is compared with the results of traditional cytomorphology. The studies indicate that the yield of mitotic cells in malignant effusions is quite high when compared to fluids with no cytological evidence ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：Background and Objectives:Salivary gland neoplasms are relatively uncommon. They have a wide variety of histopathological types with diverse biological behavior. It involves all the major and minor salivary glands in the head and neck. This article focuses on the various types of major salivary gland tumors treated at ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_466_17
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:5-Fluorouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the r...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：10.4103/0019-509X.75816
更新日期：2011-01-01 00:00:00
abstract：:We have studied fibrinolytic activity of 12 cases of infiltrating duct carcinoma of breast (7 metastatic and 5 non-metastatic) and ten cases of adenocarcinoma of gastrointestinal tract (5 each of metastatic and nonmetastatic), and compared with some of their normal tissue counterparts. Both metastatic and non-metastat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：INTRODUCTION:Sri Lanka became a signatory to the WHO Frame Work Convention on Tobacco Control in September 2003, and this was ratified in November 2003. With a view to reduce the use of tobacco in Sri Lanka, the National Authority on Tobacco and Alcohol Act (NATA) No. 27 of 2006 was implemented. AIM:To assess the beha...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.107753
更新日期：2012-10-01 00:00:00
abstract：:Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Thre...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:The use of colposcopy for follow up of patients with abnormal cervical smears has considerably increased the rate of detection of cervical malignancies and intraepithelial lesions in recent years. In case the lesion is situated high up in the cervical canal however, the chances of missing out the lesion are considerab...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Recent studies indicate neoadjuvant chemotherapy (NACT) can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF) NACT in our setting is lacking. The pr...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134649
更新日期：2014-01-01 00:00:00
abstract：CONTEXT:Tumor budding (TBud) is recognized as a poor prognostic marker in colorectal cancer (CRC) with important treatment implications in Stage II cancers and malignant polyps. There are multiple propositions for bud count reporting but without an uniformly accepted system. The International TBud consensus conference ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_642_17
更新日期：2017-10-01 00:00:00
abstract：:Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:Phyllodes tumor (PT) is a rare fibroepithelial neoplasm comprising <1% of all breast tumors. Clinical spectrum ranges from benign (B), borderline (BL), and locally recurrent to malignant (M) and metastatic type. The aim of our study was to analyze the clinicopathological factors, compare treatment options, and ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176698
更新日期：2015-07-01 00:00:00
abstract：:Serum levels of Lactate Dehydrogenase (LDH), alpha-Hydroxybutyrate Dehydrogenase (HBDH) and the relative ratio of alpha-Hydroxybutyrate Dehydrogenase to Lactate Dehydrogenase (HBDH/LDH) were determined in 51 cases of histologically proved testicular germ cell tumors and 40 healthy controls. Serum LDH and HBDH levels w...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
