Abstract:
BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our study and report further analysis of distribution of different types of EGFR mutations in 1018 non small cell lung cancer patient, and its co-relation with clinical parameters and geographical variations across the country. MATERIAL AND METHODS:This study is a retrospective analysis on all the patients who were referred for EFGR testing as a routine service over a 1.5 year period. This was part of standard care. EGFR kinase domain mutations in exon 18-21 were probed by TaqMan probe-based assays in 1018 NSCLC patients. RESULTS AND DISCUSSION:While EGFR exon 19 mutations, the most frequent EGFR mutation, were found be higher among non smokers females, we find surprisingly higher incidence of exon 21 mutations among EGFR mutation positive male smokers of Indian ethnicity. Furthermore, as Indian population is known to be composed of a gradient admixture of Ancestral North Indian (with genetic influence from Middle Easterners, Central Asians, and Europeans harboring variant EGFR mutation frequency) and Ancestral South Indians, as a paradox our study indicates comparable EGFR mutation frequency across different geographical locations within India CONCLUSION:Geographically there is uniform distribution in the EGFR mutation frequency within India. Further more, while exon 19 mutations are predominant among non smokers, higher incidence of exon 21 mutations exists among EGFR mutation positive male smokers of Indian ethnicity.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Choughule A,Noronha V,Joshi A,Desai S,Jambhekar N,Utture S,Thavamanni A,Prabhash K,Dutt Adoi
10.4103/0019-509X.117023subject
Has Abstractpub_date
2013-04-01 00:00:00pages
107-11issue
2eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2013_50_2_107_117023journal_volume
50pub_type
杂志文章abstract::A rare case of pleomorphic intimal sarcoma of pulmonary trunk is reported. The patient presented with symptoms of right ventricular out flow tract (RVOT) obstruction. Metastatic deposits were seen in lungs, diaphragm and thyroid. Bronchial mucosal involvement was also seen. The tumour showed multicentric origin and on...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::A novel mutation in the MLH1 gene likely to be pathogenic for Lynch syndrome was discovered in a proband with a family history of colon cancer. Immunohistochemistry showed negative expression of PMS2 and MLH1 in the resected tumor sample. The mutation lies at the highly conserved C-terminus of the MLH1 protein, the re...
journal_title:Indian journal of cancer
pub_type:
doi:10.4103/ijc.IJC_349_18
更新日期:2018-10-01 00:00:00
abstract::A seventy year old man presented with bone pains. Investigation revealed a metastatic bone lesion in the humerus. The primary was found in the liver. The patient achieved good palliation with chemotherapy and radiotherapy and survived for one year. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Radiation induced wet desquamation of skin in carcinoma breast patients is a painful condition. In this study topical beclomethasone dipropionate spray was used as prophylaxis with the purpose of reducing risk of the wet desquamation of skin in irradiated field. MATERIALS AND METHODS:Sixty patients...
journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.4103/0019-509x.29424
更新日期:2006-10-01 00:00:00
abstract::A case report of a squamous cell carcinoma arising in a dermoid cyst of the ovary in a 29 year old patient is presented. Such an occurrence in young patients is unusual. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Prostate cancer is one of the most common malignancies of elderly males. Management depends on the accurate estimation of disease both at initial diagnosis and in its subsequent course. In the present study, we evaluated the diagnostic utility of positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) in p...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.73572
更新日期:2010-10-01 00:00:00
abstract::Casual Interpretation of results in a given article has several pitfalls. In order to assess the strengths and limitations of a given article several factors need to be considered. This review article is intended to list, classify and describe briefly the factors that should be considered in the evaluation of an artic...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-06-01 00:00:00
abstract::A total of forty bone marrow trephine biopsies and aspirates were studied from thirty five patients suffering from Hodgkin's disease during the two year period 1994 and 1995. Of these twenty five were at the time of diagnosis of the disease and fifteen after treatment. The biopsies were studied for incidence of involv...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Renal cancer is one of the common malignant tumors of the urinary system, seriously threatening human being's health. The current discoveries, however, are far enough for efficient and secure treatment of renal cancer. AIMS:The aim was to explore the mechanism of matrix metalloproteinase-7 (MMP-7) protein i...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.180835
更新日期:2016-01-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 历史文章,杂志文章
doi:10.4103/ijc.IJC_13_19
更新日期:2019-07-01 00:00:00
abstract::Primary undifferentiated embryonal of the liver in children is a rare neoplasm with dismal prognosis. Surgery is the treatment of choice. Adjuvant chemotherapy may prove useful in improving the prognosis of these tumours. We report two cases of Primary undifferentiated embryonal sarcoma of the liver. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract::The utility of computed tomography in pretherapy assessment of esophageal carcinoma is reviewed. Computed tomographic findings in 78 patients with histologically proved esophageal carcinoma were corelated with findings at surgery and histopathology. Computed tomography (CT) was found to be fairly accurate in assessing...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:Background:Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL). Methods:In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived inducti...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_110_19
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175332
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:We aimed to study the compliance and treatment outcome of patients who received adjuvant treatment following curative resection for periampullary cancers periampullary cancers. MATERIALS AND METHODS:Institute medical records of PAC treated during 2007-2014 were retrieved. Demographics, treatment, and outcom...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_358_17
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:This study was undertaken to report the results of weekly combination chemotherapy with cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (R/M SCCHN). MATERIALS AND METHODS:Retrospective analysis of 35 R/M SCCHN patients who received cetuximab with weekly paclitaxel and platin (cisplat...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.98906
更新日期:2012-01-01 00:00:00
abstract::Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:This retrospective study was performed in a tertiary care center from India analyzing the histopathological reports and the clinical data of the adult patients admitted in this institute with a diagnosis of renal tumors and had undergone nephrectomy for the disease. OBJECTIVE:The objective of this study is ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.180837
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Ephrin A4 is one of the ephrin ligand molecules belonging to the tyrosine kinases receptor family. It was originally identified in a T-lymphoma cell line and seen to be expressed in human adult tissue as well as several tumor types. In our previous study, we showed the unique pattern of ephrin A4 immunohisto...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.58859
更新日期:2010-01-01 00:00:00
abstract::The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent of all salivary gland tumors. Central mucoepidermoid carcinoma of the jaws is rare. Following is a case report of central mucoepidermoid carcinoma which involves the ramus of the mandible. Origin of the central mucoepidermoid carcinoma is discuss...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::The procedure of facial resurfacing dictates that there should be an excellent colour and texture match between the facial and the transposed skin. Cervical flaps e.g. platysma flap are commonly used for reconstruction of facial defects but, with disadvantages like limited mobility, unacceptable donor site and unpredi...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:INTRODUCTION:Sri Lanka became a signatory to the WHO Frame Work Convention on Tobacco Control in September 2003, and this was ratified in November 2003. With a view to reduce the use of tobacco in Sri Lanka, the National Authority on Tobacco and Alcohol Act (NATA) No. 27 of 2006 was implemented. AIM:To assess the beha...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.107753
更新日期:2012-10-01 00:00:00
abstract::Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the report...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Nonsmall cell lung cancer is the leading cause of cancer mortality worldwide because of distant metastasis and frequent recurrence. Only few reliable and easily accessible tumor markers have been clinically implemented to the early nonsmall cell cancer prognosis. OBJECTIVE:The purpose of this study is to de...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172509
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:In our center, we routinely use CCNU (Lomustine) as salvage treatment in high-grade glioma patients who cannot afford bevacizumab. This exploratory analysis was done to report the efficacy and toxicity associated with this regimen. METHODS:Patients who were treated with salvage CCNU (postexposure to temoz...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.204774
更新日期:2016-10-01 00:00:00
abstract::Over the past few decades, considerable success has been achieved in the field of cancer treatment with biological response modifiers (BRM), which are agents that improve the body's ability to fight cancer by immunostimulation. Biological agents, such as interferons and interleukins, provide nonspecific active immunit...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.73559
更新日期:2010-10-01 00:00:00
abstract::Sentinel node localization is the second most important development in this century after conservative lumpectomy for the treatment of early breast cancer. The sentinel node mapping is a new multidisciplinary approach for staging of axilla in an accurate and less morbid way as compared to axillary node dissection. Sen...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:2003-04-01 00:00:00
abstract::It is important to differentiate non-dyplastic aplastic anaemia from hypocellular myelodysplastic syndrome (MDS). Four patients presenting with hypocellular bone marrow and different evolution patterns are being described. Certain morphological features and variable hypocellularity were found to be useful indices for ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::The clinical microbiology department at CMC&H, Vellore in conjunction with the haematology department carries out routine surveillance of patients admitted to the hematology department. Since 1994 in a sample population of 55 patients with various underlying clinical conditions who have had bone marrow transplant, sep...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00