Abstract:
BACKGROUND:Renal cancer is one of the common malignant tumors of the urinary system, seriously threatening human being's health. The current discoveries, however, are far enough for efficient and secure treatment of renal cancer. AIMS:The aim was to explore the mechanism of matrix metalloproteinase-7 (MMP-7) protein in renal carcinoma cell metastasis by bioinformatics analysis. MATERIALS AND METHODS:Bioinformatics methods were used to analyze the composition of amino acids, as well as transmembrane structure, coiled coils, subcellular localization, signal peptide, functions and structures at all levels. RESULTS AND CONCLUSIONS:It showed that the gene MMP-7 totally had 1131 bp. A peptide chain containing 267 amino acids was encoded in the coding region. Based on random coil, α helix, and further super-helix, it had formed a stable neutral hydrophilic protein. The subcellular location analysis indicated that the protein was located outside the cell. The mature peptide started from the 18th amino acid, and its front-end was the sequence of the signal peptide, belonging to the secreted protein. Analysis of the functional domain showed that this protein had two functional domains, the PG binding domain, and the zinc finger binding domain. Moreover, the protein, which was cross-linked with it, was also one related to cancer cell proliferation and metastasis. To sum up, MMP-7 is a stable neutral hydrophilic secreted protein, and it may play a vital role in the invasion and metastasis of cancer cells.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Li L,Wang LX,Xu GL,Yang F,Gao QL,Niu H,Shi B,Jiang Xdoi
10.4103/0019-509X.180835subject
Has Abstractpub_date
2016-01-01 00:00:00pages
13-8issue
1eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2016_53_1_13_180835journal_volume
53pub_type
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Indian journal of cancer
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doi:
更新日期:1997-09-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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pub_type: 杂志文章
doi:
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
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journal_title:Indian journal of cancer
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更新日期:2000-12-01 00:00:00
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