Abstract：
BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a cause and effect relationship between mitochondrial OXPHOS defects and tumor progression. MATERIALS AND METHODS:Mutational, expression and functional analysis of l2 of the 13 mitochondrial OXPHOS genes has been carried out using PCR, Real-Time PCR and protein modeling in 180 sporadic samples of a heterogeneous group of benign and malignant tumors like that of benign, malignant, matched blood and adjacent normal tissue of breast and benign hemangioma. RESULTS:Mutations were identified in the ND4L, ND6 and COX-II regions of the mitochondrial OXPHOS genes. All the mutations were limited only to the malignant breast tissues. On relative quantification, a compromised expression of OXPHOS genes was identified in all the malignant tissues irrespective of their mutational states. Protein modeling revealed loss of function mutations of ND6 and COX-II proteins. CONCLUSION:This is the first study worldwide wherein a comparative study using different benign and malignant tumors has been carried out to assess the role of Mt DNA defects. Our data reveals mitochondrial dysfunction only in malignant cells and not in their benign counterparts, indicating that the dysfunction may arise after the pro-proliferative pathway has set in. We hypothesize that compromised OXPHOS may be a responsive mechanism of the cell to counter cancers, rather than a mechanism of initiating tumorigenesis.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Chintha R,Kaipa PR,Sekhar N,Hasan Qdoi
10.4103/0019-509X.118732subject
Has Abstractpub_date
2013-07-01 00:00:00pages
206-13issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2013_50_3_206_118732journal_volume
50pub_type
杂志文章abstract：:Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.178403
更新日期：2015-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_719_18
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175827
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.58859
更新日期：2010-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.107753
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 历史文章,杂志文章
doi：10.4103/ijc.IJC_13_19
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.73559
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151994
更新日期：2015-02-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82901
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_273_18
更新日期：2019-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.25773
更新日期：2006-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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