Abstract:
CONTEXT AND AIM:The prognosis of primary gliosarcoma (PGS) remains dismal with current treatment modalities. We analyzed the outcome of PGS patients treated with concurrent and adjuvant temozolomide (TMZ). SETTINGS AND DESIGN:Retrospective single institutional analysis. MATERIALS AND METHODS:We retrospectively evaluated 27 patients of PGS treated with radiotherapy (RT) and TMZ during 2007-2012. STATISTICAL ANALYSIS USED:Overall survival (OS) was estimated by the use of Kaplan Meier method and toxicities were evaluate using common terminology criteria for adverse events version 2.0 (National Cancer Institute, USA). RESULTS:Median age at presentation and Karnofsky performance status was 45 years and 90 respectively and male: female ratio was 20:7. Patients received adjuvant RT to a total dose of 60 Gy at 2 Gy/fraction. All patients except 5 received adjuvant TMZ to a median number of 6 cycles. Grade 2 and 3 hematological toxicity was seen in 8% and 4% of patients respectively during concurrent RT. During adjuvant chemotherapy, 13.6% had Grade 3 thrombocytopenia and 9.5% had Grade 3 neutropenia. Median OS was 16.7 months (1 year and 2 year actuarial OS was 70.8% and 32.6% respectively). Adjuvant TMZ was associated with a better survival (median survival 21.21 vs. 11.93 months; P = 0.0046) on univariate analysis and also on multivariate analysis (hazard ratio 1.82, 95% confidence interval: 1.503-25.58; P = 0.012). CONCLUSIONS:The results of our study, largest series of patients with PGS treated with concurrent and adjuvant TMZ shows an impressive survival with acceptable toxicity. We suggest TMZ be included in the "standard of care" for this tumor.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Rath GK,Sharma DN,Mallick S,Gandhi AK,Joshi NP,Haresh KP,Gupta S,Julka PKdoi
10.4103/0019-509X.178407subject
Has Abstractpub_date
2015-10-01 00:00:00pages
599-603issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2015_52_4_599_178407journal_volume
52pub_type
杂志文章abstract::Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, the...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/ijc.IJC_455_19
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.49154
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abstract:BACKGROUND:We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC. PATIENTS AND METHODS:The ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176736
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175318
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.154058
更新日期:2014-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.107735
更新日期:2012-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172509
更新日期:2015-12-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::The clinical microbiology department at CMC&H, Vellore in conjunction with the haematology department carries out routine surveillance of patients admitted to the hematology department. Since 1994 in a sample population of 55 patients with various underlying clinical conditions who have had bone marrow transplant, sep...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.200677
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.84932
更新日期:2011-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_524_19
更新日期:2020-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.123611
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journal_title:Indian journal of cancer
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doi:
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 历史文章,杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Adjuvant treatment in gastric adenocarcinoma has been a challenge for the treating specialists, and despite several trials, a clear consensus is yet to be defined. The higher propensity for lymph nodal involvement and locoregional recurrences led to the hypothesis that locoregional and systemic treatments need to be e...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/ijc.IJC_375_18
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Esophageal cancer (EC) is one of the most frequent and serious cancers worldwide, but its geographic distribution is disparate. Northern Iran is known as one of the hot spots for EC, but there is inadequate evidence available regarding its characteristics in northwestern region of Iran. Therefore, this study...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.82875
更新日期:2011-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.178434
更新日期:2015-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00