Abstract:
BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic leukemia (ALL) cases in our geographic setting. MATERIALS AND METHODS:A total of 639 new pediatric ALL cases immunophenotyped during 1989-2009 forms the basis of this analysis. Representative bone marrow or peripheral blood of these patients was immunophenotyped flowcytometrically using an extensive panel of monoclonal antibodies. RESULTS:During early phase of our study we noticed a relative excess of T-ALL and a paucity of common acute lymphoblastic leukemia (C-ALL) in contrast to western data. Over a period of 20 years we witnessed a gradual reduction in pediatric T-ALL cases and a proportionate increase in C-ALL cases. CONCLUSION:We find that this change of pattern is synchronizing with the socioeconomic and industrial development prevailing in our geographic setting and suggest a possible link between the predominant immunophenotype of pediatric ALL cases and the environmental and socioeconomic factors prevailing in that locality.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Rajalekshmy KR,Abitha AR,Anuratha N,Sagar TGdoi
10.4103/0019-509X.84932subject
Has Abstractpub_date
2011-07-01 00:00:00pages
310-5issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2011_48_3_310_84932journal_volume
48pub_type
杂志文章abstract:Background:Ki-67 index is an important prognostic marker in breast cancer and is also used to differentiate luminal A subtype from luminal B. Inter-observer variations in determining the index and the cut-off value to be considered in distinguishing the two subtypes remain problems in clinical practice. Methods:MIB-1 ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_719_18
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES:The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_155_17
更新日期:2017-01-01 00:00:00
abstract::Wide resection of bone tumour has become an accepted treatment in the limb salvage surgery. The reconstruction of the residual defect following wide resection is a major problem. The motions of involved joint after resection of the large tumour can be restored by using either the osteoarticular allograft or endoprosth...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract::Treatment of cancer is limited by affordability of patients in the many developing countries including India. Generic drug manufacturers have responded to this scenario by making drugs available at affordable costs, often at less than 10% the cost of the original brand. In our practice, it is found that there is a thr...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.146723
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatin...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176715
更新日期:2015-07-01 00:00:00
abstract::Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage II...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Isolated central nervous metastasis is rare in patients with Ewing's sarcoma. Here we report two cases with CNS metastasis as the sole manifestation of relapse with a brief review of the literature. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175321
更新日期:2014-10-01 00:00:00
abstract::Prostate cancer is one of the most common malignancies of elderly males. Management depends on the accurate estimation of disease both at initial diagnosis and in its subsequent course. In the present study, we evaluated the diagnostic utility of positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) in p...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.73572
更新日期:2010-10-01 00:00:00
abstract::A case of low grade hemangiopericytoma of three years duration occurring in the upper end of the femur of a 70 year old man is described. Radiologically, the upper third of the right femur showed a destructive expansile osteolytic lesion with soft tissue extension. The tumour was partially encapsulated. Mitoses were 0...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Non-urothelial bladder tumors (NUBTs) are uncommon accounting for approximately 10% of the total urinary bladder tumors while 90% are urothelial in origin. There are very limited comprehensive studies on NUBTs. AIMS AND OBJECTIVES:The objectives of the study were to analyze the clinicopathological and immun...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_459_17
更新日期:2019-07-01 00:00:00
abstract::Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:There is limited data from India regarding elderly non-Hodgkin's lymphomas (NHL) patients. Hence, this audit was planned to study the clinic-pathological features and treatment outcomes in elderly NHL patients. METHODS:Retrospective analysis of all NHL patients above age of 59 years treated at the author'...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.178434
更新日期:2015-10-01 00:00:00
abstract::We report a rare case of 'metastatic invasive mole' to the spinal cord causing paraplegia in a 19-year-old woman. There are no such histologically proven reports in the literature since the use of the tumour marker, beta-subunit of human chorionic gonadotrophin (beta-HCG) and chemotherapy. We stress the importance of ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Activating mutations in the epidermal growth factor receptor gene and rearrangement of the anaplastic lymphoma kinase gene exemplify the molecular characterization of nonsmall cell lung cancer (NSCLC), particularly adenocarcinoma, and its therapeutic relevance. Several genetic alterations with prognostic and predictiv...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/ijc.IJC_258_17
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) derived from Plumbago species is a potential anti-tumour agent. Plumbagin has been tested for anti-cancer activity in vitro and in vivo using mice model. AIM:To study the tumour suppressing efficacy of plumbagin using zebrafish model. MATERIALS AND METHODS:H...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.219580
更新日期:2017-01-01 00:00:00
abstract::Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.178403
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Recently published prospective clinical trials and two meta-analyses have shown that addition of induction chemotherapy (IC) to concurrent chemoradiation (CRT) could potentially improve outcomes in comparison to CRT alone, in locoregionally advanced nasopharyngeal carcinoma (LANPC). Although it remains uncle...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_115_18
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The product of Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.55550
更新日期:2009-10-01 00:00:00
abstract::Cytogenetic analysis using G-banding techniques for the diagnosis of malignancy in pleural and peritoneal effusions is compared with the results of traditional cytomorphology. The studies indicate that the yield of mitotic cells in malignant effusions is quite high when compared to fluids with no cytological evidence ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::A composite tumour of the caecum and colon, comprising of distinct areas of classical carcinoid and of well differentiated adenocarcinoma is described. Both components were histochemically confirmed. Presence of a morphologic transition at junctional areas favour a histogenesis from bi-directional differentiation of m...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172519
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treat...
journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.4103/0019-509X.178374
更新日期:2015-10-01 00:00:00
abstract::Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.15098
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.35810
更新日期:2007-04-01 00:00:00
abstract::This note presents a brief account of the ideas and efforts of V.R. Khanolkar in the period 1952-1962 to develop the Indian Cancer Research Centre into a "center of excellence". Khanolkar, who is recognized as a pioneer in cancer research in India, focused on developing multidisciplinary medical research and mentored ...
journal_title:Indian journal of cancer
pub_type: 传,历史文章,杂志文章
doi:10.4103/ijc.IJC_14_19
更新日期:2019-10-01 00:00:00
abstract::Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent of all salivary gland tumors. Central mucoepidermoid carcinoma of the jaws is rare. Following is a case report of central mucoepidermoid carcinoma which involves the ramus of the mandible. Origin of the central mucoepidermoid carcinoma is discuss...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Globally tobacco epidemic kills nearly six million people annually. Consumption of tobacco products is on the rise in low- and middle-income countries. Tobacco is addictive; hence, tobacco users need support in quitting. AIMS:Providing tobacco cessation services to women in community enabling them to quit t...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.147474
更新日期:2014-12-01 00:00:00