Abstract:
OBJECTIVE:The aim of the present study was to evaluate the efficacy and safety of pemetrexed chemotherapy combined with intrapleural injection of pemetrexed and bevacizumab in the treatment of malignant pleural mesothelioma (MPM)-mediated malignant pleural effusion, and analyze the objective response rate (ORR), the median progression-free survival (PFS) and the median overall survival (OS). METHODS:We analyzed the clinical data of 23 MPM patients with pleural effusion who were treated with a combination chemotherapy of pemetrexed at 500 mg/m 2 , on day 1 plus cisplatin (DDP) at 20 mg/m 2 on day 1-5 of each 21 days cycle, and concurrently, intrapleural injection of pemetrexed 0.5 g and bevacizumab 300 mg was administered on day 3 or day 4 after complete effusion drainage. ELISA test was applied to detect the vascular endothelial growth factor (VEGF) level in the pleural effusion and serum, and assess the ORR and survival. RESULTS:In the 23 evaluable patients, the VEGF level in the pleural effusion and serum was significantly decreased, P < 0.01, pleural effusion of 20 patients (86.96%) was controlled effectively. There were 8 complete responses, 7 partial responses, 5 stable disease and 3 progressive disease, the ORR was 65.21%, the disease control rate was 86.96%, the median PFS was 6 months, the median OS was 14.5 months, and the 1-year survival rate was 41.22%. Toxicities were generally mild and manageable; the major toxicities included myelosuppression, fatigue, and anemia, mainly were grade 1-2 which could be managed by symptomatic treatments. CONCLUSION:The combination of pemetrexed chemotherapy with intrapleural injection of pemetrexed and bevacizumab is efficacious and safe for MPM pleural effusion, and results of the present study demonstrate some improvement in the PFS and OS. The expression of VEGF in the pleural effusion and serum plays a guiding role in monitoring the efficacy of bevacizumab in the treatment of malignant pleural effusion.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Chen D,Li X,Zhao H,Fu Y,Yao F,Hu J,Du Ndoi
10.4103/0019-509X.154058subject
Has Abstractpub_date
2014-03-01 00:00:00pages
e82-5eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2014_51_7_82_154058journal_volume
51 Suppl 3pub_type
杂志文章abstract:BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.84932
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC. PATIENTS AND METHODS:The ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176736
更新日期:2015-07-01 00:00:00
abstract::The clinical microbiology department at CMC&H, Vellore in conjunction with the haematology department carries out routine surveillance of patients admitted to the hematology department. Since 1994 in a sample population of 55 patients with various underlying clinical conditions who have had bone marrow transplant, sep...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treat...
journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.4103/0019-509X.178374
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.25773
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.15098
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Phyllodes tumor (PT) is a rare fibroepithelial neoplasm comprising <1% of all breast tumors. Clinical spectrum ranges from benign (B), borderline (BL), and locally recurrent to malignant (M) and metastatic type. The aim of our study was to analyze the clinicopathological factors, compare treatment options, and ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176698
更新日期:2015-07-01 00:00:00
abstract::Resection or loss of a portion of the mandible can result in a variety of functional, cosmetic and psychological deficits that are dependent on the extent of the defect, the concomitant therapy and the timing of rehabilitative efforts. These impairments greatly affect the patient's Quality of life (QOL). The thrust in...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.112282
更新日期:2013-01-01 00:00:00
abstract::In the cervical cancer cases registered at the Cancer Hospital at Barshi, India during 1988-90, 99 of the 105 cases were clinically staged (Total number of cases registered: 136). The annual number of cases were too few for a comparison of stage distribution between the registry years. However, comparison of the propo...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:INTRODUCTION:In our center, we routinely use CCNU (Lomustine) as salvage treatment in high-grade glioma patients who cannot afford bevacizumab. This exploratory analysis was done to report the efficacy and toxicity associated with this regimen. METHODS:Patients who were treated with salvage CCNU (postexposure to temoz...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.204774
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:This study was undertaken to report the results of weekly combination chemotherapy with cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (R/M SCCHN). MATERIALS AND METHODS:Retrospective analysis of 35 R/M SCCHN patients who received cetuximab with weekly paclitaxel and platin (cisplat...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.98906
更新日期:2012-01-01 00:00:00
abstract::Gliomatosis cerebri is a vary rare neoplastic lesion of the central nervous system. An intra-vitam diagnosis of gliomatosis cerebri can be suggested with a steleolactic biopsy of the lesion in conjunction with Magnetic Resonance Imaging (MRI) findings in the brain. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:CONTEXT:Malnutrition is prevalent in children with cancer at diagnosis, especially in low- and middle-income countries (LMIC) where the great majority of children live. It is associated with an added burden of morbidity and mortality. AIMS:Answers were sought to the best measure of nutritional status in LMIC, the impa...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.175827
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.197726
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.118732
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The deregulation of microRNA-185 (miR-185) has been showed to be associated with many cancers and act as a tumor suppressor in many types of human malignancies. We hence tried to find out its role in human colorectal cancer (CRC). MATERIALS AND METHODS:miR-185 expression was investigated by real-time quantit...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.186576
更新日期:2015-12-01 00:00:00
abstract:AIMS:The aim of this study is to investigate the activity and toxicity of etoposide with AUC 6 doses of carboplatin in patients with previously untreated extensive disease - small-cell lung cancer (SCLC). MATERIALS AND METHODS:88 eligible patients were treated with chemotherapy comprised of carboplatin AUC of 6, IV da...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.92279
更新日期:2011-10-01 00:00:00
abstract::The office of the Drugs Controller General (India) vide order dated 19 th November 2013 has made audio visual (AV) recording of the informed consent mandatory for the conduct of all clinical trials in India. We therefore developed a standard operating procedure (SOP) to ensure that this is performed in compliance with...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.138158
更新日期:2014-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. AIM:To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.197725
更新日期:2016-04-01 00:00:00
abstract::Positron emission tomography (PET) has emerged as an important diagnostic tool in the management of lung cancers. Although PET is sensitive in detection of lung cancer, but FDG (2-deoxy-2- 18 fluro-D-glucose) is not tumor specific and may accumulate in a variety of nonmalignant conditions occasionally giving false pos...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509x.44660
更新日期:2008-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.180837
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Breast cancer is the second most common cancer in the Indian female population. As per our hospital data, breast cancer is also found to be the second leading malignancy in women. Hence, we undertook this study to evaluate the clinical profile, histopathologic types, grade, stage and the progn...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.123594
更新日期:2013-10-01 00:00:00
abstract::Available data on cancer mortality in the combined employee populations of five units of the Department of Atomic Energy, namely those in Mumbai, Tarapur, Kalpakkam, Hyderabad and Alwaye, with study periods ranging between 13 and 21 years, have been analysed. Data are available only on those still serving, i.e., subje...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Breast cancer is now the most common cancer in many parts of India and the incidence varies from 12 to 31/100,000, and is rising. Locally advanced breast cancer (LABC) accounts for 30-35% of all cases of breast cancers in India. LABC continues to present a challenge and imposes a major health impact in our c...
journal_title:Indian journal of cancer
pub_type: 临床试验,杂志文章
doi:10.4103/0019-509X.75838
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.49154
更新日期:2009-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_155_17
更新日期:2017-01-01 00:00:00