Abstract：
BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with respect to the clinical profile, treatment and survival. METHODS:All newly diagnosed ovarian tumors in children up to 14 years of age, registered in our Pediatric Oncology Division between January 2000 and December 2009 were retrospectively reviewed. OBSERVATIONS:There were 47 patients with newly diagnosed ovarian tumors. The mean age at presentation was 10.0 ± 3.4 years. The most common symptoms at presentation were acute abdominal pain (48.9%) and abdominal mass (40.4%). Precocious puberty was uncommon (6.3%). Histology was germ cell tumors in 44 cases and nongerm cell tumors in three cases. The benign teratomas (mature and immature grade 1 and 2; n=9) underwent complete surgical resection alone; none had recurrence on follow up. Of the remaining 35 GCTs, 31 patients were given chemotherapy and 4 refused treatment.26 out of the 31 patients completed chemotherapy with BEP (bleomycin, etoposide, cisplatin) regimen with acceptable toxicities. 5 children i.e.; (19.2%) developed recurrence. At a median follow up of 80 months, 10 year disease free survival was 80.8 ± 7.7% and 10 year overall survival was 92.7 ± 4.9%. CONCLUSION:Germ cell tumors are the most common ovarian malignancy in children. With surgery and chemotherapy using BEP, good outcome can be expected in these patients.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Rajeswari B,Nair M,Ninan A,Parukuttyamma Kdoi
10.4103/0019-509X.197726subject
Has Abstractpub_date
2016-04-01 00:00:00pages
292-295issue
2eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2016_53_2_292_197726journal_volume
53pub_type
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journal_title：Indian journal of cancer
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pub_type： 杂志文章
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2000-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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journal_title：Indian journal of cancer
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pub_type： 临床试验,杂志文章
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Indian journal of cancer
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更新日期：1989-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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更新日期：2014-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Indian journal of cancer
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