Abstract：
BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to treat. Risk predictors obtained from Western studies on pediatric FN are unlikely to be relevant to low middle-income country (LMICs). Our study aimed to identify clinical and laboratory parameters predictive of poor outcomes in children with chemotherapy-induced FN in a LMIC. PROCEDURE:Two hundred and fifty consecutive episodes of chemotherapy-induced FN in pediatric (<15 years) patients were analyzed prospectively. Adverse outcomes were defined as per SPOG 2003 FN study as serious medical complications (SMC) due to infection, microbiologically defined infection, and radiologically defined pneumonia (RDP). Variables found to be significant for adverse outcome (P < 0.05) on univariate analysis were selected for multivariate analysis. RESULTS:Five factors that were found to independently predict adverse outcome were (a) previously documented infection in the past 6 months, (b) presence of significant focus of infection, (c) absolute phagocyte count <100/mm3, (d) peak temperature more than 39°C in this episode of FN, and (e) fever lasting more than 5 days during this episode of FN. CONCLUSIONS:Identifying the risk factors for adverse outcome in pediatric FN, which are objective and applicable across LMICs would contribute in developing guidelines for the management of FN in a resource-limited setting.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Prasad M,Chinnaswamy G,Arora B,Vora T,Hawaldar R,Banavali Sdoi
10.4103/0019-509X.175321subject
Has Abstractpub_date
2014-10-01 00:00:00pages
432-7issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2014_51_4_432_175321journal_volume
51pub_type
杂志文章abstract：:The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaem...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175332
更新日期：2014-10-01 00:00:00
abstract：PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions o...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.84932
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:The prognostic relevance of histologic differentiation in gastric carcinoma patients with curative resection is unclear. We analyzed the clinicopathologic features of gastric carcinoma patients with curative resection according to the histologic differentiation and evaluated surgical outcome. MATERIALS AND ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175569
更新日期：2015-01-01 00:00:00
abstract：:Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatin...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176715
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical eff...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.204767
更新日期：2016-10-01 00:00:00
abstract：:Sentinel node localization is the second most important development in this century after conservative lumpectomy for the treatment of early breast cancer. The sentinel node mapping is a new multidisciplinary approach for staging of axilla in an accurate and less morbid way as compared to axillary node dissection. Sen...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：2003-04-01 00:00:00
abstract：:Cervical cancer is the leading malignancy among Indian women. It has been estimated that in the absence of any control programme, the incident number of cervical cancer cases in the country would rise to 140 thousand by the turn of this century. Cytology screening remains the main stay for the control of cervix cancer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：INTRODUCTION:There is limited data from India regarding elderly non-Hodgkin's lymphomas (NHL) patients. Hence, this audit was planned to study the clinic-pathological features and treatment outcomes in elderly NHL patients. METHODS:Retrospective analysis of all NHL patients above age of 59 years treated at the author'...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.178434
更新日期：2015-10-01 00:00:00
abstract：:A rare case of pleomorphic intimal sarcoma of pulmonary trunk is reported. The patient presented with symptoms of right ventricular out flow tract (RVOT) obstruction. Metastatic deposits were seen in lungs, diaphragm and thyroid. Bronchial mucosal involvement was also seen. The tumour showed multicentric origin and on...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors incl...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.76625
更新日期：2011-01-01 00:00:00
abstract：:Colloid cyst is a rare benign intracranial neoplasm, commonly located in the third ventricle. Though headache and visual symptoms are classical, the patients may present with sudden neurological deterioration. We present a ten-year-old male child who presented with sudden neurological deterioration due to colloid cyst...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. AIM:To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197725
更新日期：2016-04-01 00:00:00
abstract：:A study of knowledge, attitude and practice with regard to tobacco usage was conducted in 1278 boys and 353 girls studying in the final year in various schools in Bombay. The proportion of boys given to one or the other form of tobacco usage (including experimenters/triers) was significantly higher in private English ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:"A Roadmap to Tackle the Challenge of Antimicrobial Resistance - A Joint meeting of Medical Societies in India" was organized as a pre-conference symposium of the 2 nd annual conference of the Clinical Infectious Disease Society (CIDSCON 2012) at Chennai on 24 th August. This was the first ever meeting of medical soci...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/0019-509X.104065
更新日期：2013-01-01 00:00:00
abstract：:We present an interesting case of port site metastasis is a menopausal women subsequent to diagnostic laparoscopy undertaken for chronic pelvic pain, which later proved early ovarian malignancy as the source of primary. While cases of port site metastasis have mostly occurred after extensive disease the possbility of ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:Spindle cell haemangioendothelioma (SCH) is a low grade, slowly progressive angiosarcoma of multifocal nature with local recurrences being common. It is histologically marked by cavernous blood spaces and a spindle cell stroma. Its importance lies in recognising its relatively benign nature and differentiating it from...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:This note presents a brief account of the ideas and efforts of V.R. Khanolkar in the period 1952-1962 to develop the Indian Cancer Research Centre into a "center of excellence". Khanolkar, who is recognized as a pioneer in cancer research in India, focused on developing multidisciplinary medical research and mentored ...
journal_title：Indian journal of cancer
pub_type： 传,历史文章,杂志文章
doi：10.4103/ijc.IJC_14_19
更新日期：2019-10-01 00:00:00
abstract：:Uncommon patterns of presentation of acute leukemia pose diagnostic problems. A rheumatological prodrome in acute myeloblastic leukemia is very rare. We describe one such patient who had a normal haemogram. Bone marrow examination done later revealed acute myeloblastic leukemia. The case is discussed with reference to...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146774
更新日期：2014-07-01 00:00:00
abstract：AIMS:The aim of this study is to investigate the activity and toxicity of etoposide with AUC 6 doses of carboplatin in patients with previously untreated extensive disease - small-cell lung cancer (SCLC). MATERIALS AND METHODS:88 eligible patients were treated with chemotherapy comprised of carboplatin AUC of 6, IV da...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.92279
更新日期：2011-10-01 00:00:00
abstract：:Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Casual Interpretation of results in a given article has several pitfalls. In order to assess the strengths and limitations of a given article several factors need to be considered. This review article is intended to list, classify and describe briefly the factors that should be considered in the evaluation of an artic...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC. PATIENTS AND METHODS:The ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176736
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:This retrospective study was performed in a tertiary care center from India analyzing the histopathological reports and the clinical data of the adult patients admitted in this institute with a diagnosis of renal tumors and had undergone nephrectomy for the disease. OBJECTIVE:The objective of this study is ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.180837
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to evaluate the efficacy and safety of pemetrexed chemotherapy combined with intrapleural injection of pemetrexed and bevacizumab in the treatment of malignant pleural mesothelioma (MPM)-mediated malignant pleural effusion, and analyze the objective response rate (ORR), the me...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.154058
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulf...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_349_17
更新日期：2017-07-01 00:00:00
