Monotherapy versus combination therapy against carbapenem-resistant Gram-negative bacteria: A retrospective observational study.


BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical effectiveness of CCT over monotherapy in patients with CRGNB. MATERIALS AND METHODS:We conducted a retrospective, observational study of patients with CRGNB bloodstream infections in our oncology and bone marrow transplant center. RESULTS:Over a 3-year study period (2011-2014), we could identify 91 patients satisfying study criteria. There was no statistically significant difference in the 28-day mortality between monotherapy and combination therapy arms (mono n = 26, mortality 10 (38.5%); combination n = 65, mortality 28 (40%); P = 0.886). Neutropenic patients with Enterobacteriaceae bloodstream infections performed better with combination therapy (mono n = 7, mortality 6 (85.7%); combination therapy n = 22, mortality 8 (36.4%); P = 0.035). There was no significant difference in the 28-day mortality between the two treatment arms in other subgroups. CONCLUSION:Our study did not find CCT superior to colistin monotherapy in patients with CRGNB blood stream infections; except in the subgroup of neutropenic patients with Enterobacteriaceae bloodstream infections, where combination therapy performed better.


Indian J Cancer


Indian journal of cancer


Ghafur A,Devarajan V,Raja T,Easow J,Raja MA,Sreenivas S,Ramakrishnan B,Raman SG,Devaprasad D,Venkatachalam B,Nimmagadda R




Has Abstract


2016-10-01 00:00:00














  • Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

    abstract::Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...

    journal_title:Indian journal of cancer



    authors: Totadri S,Sundersingh S,Natarajan R,Seshadri RA,Radhakrishnan V

    更新日期:2018-07-01 00:00:00

  • Importance of repeat tissue biopsy and tissue-based epidermal growth factor receptor T790M testing in progressed nonsmall cell lung carcinoma patients upon negative plasma genotyping for selection of third-generation tyrosine kinase inhibitor therapy: A c

    abstract::Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mu...

    journal_title:Indian journal of cancer



    authors: Mistry R,Patil A

    更新日期:2017-12-01 00:00:00

  • Actinomycosis mimicking carcinoma of the maxillary sinus.

    abstract::Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Pradhan S,Datta NR,Prasad KN,Ayyagari S,Pandey R

    更新日期:1993-03-01 00:00:00

  • Chylothorax in children with cancer: A milky predicament.

    abstract::Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series fro...

    journal_title:Indian journal of cancer



    authors: Totadri S,Trehan A,Bhattacharya A,Bansal D,Attri SV,Srinivasan R

    更新日期:2017-10-01 00:00:00

  • Extranodal sinus histiocytosis with massive lymphadenopathy--a case report.

    abstract::Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the report...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Naresh KN,Mukherjee G,Rao CR,Hazarika D,Kumar BN,Appaji L,Kumari BS

    更新日期:1992-12-01 00:00:00

  • Integrated positron emission tomography/computed tomography fusion imaging: an emerging gold standard in lung cancer.

    abstract::Positron emission tomography (PET) has emerged as an important diagnostic tool in the management of lung cancers. Although PET is sensitive in detection of lung cancer, but FDG (2-deoxy-2- 18 fluro-D-glucose) is not tumor specific and may accumulate in a variety of nonmalignant conditions occasionally giving false pos...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Joshi SC,Pant I,Hamzah F,Kumar G,Shukla AN

    更新日期:2008-10-01 00:00:00

  • Cancer profile in the Department of Pathology of Sri Devaraj Urs Medical College, Kolar: a ten years study.

    abstract:CONTEXT:Cancer profile varies in different regions and depends on race, lifestyle and diet. The study of a cancer profile helps to know the common cancers in a particular population, its probable risk factors and also helps in cancer control programs. AIM:To study the cancer profile at Kolar, based on Pathology Depart...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kalyani R,Das S,Bindra Singh MS,Kumar H

    更新日期:2010-04-01 00:00:00

  • Myoepithelial expression of Fas and strong nuclear expression of FasL in epithelial cells: a marker for risk stratification of breast cancer.

    abstract:AIM:The clinical significance of Fas and FasL in hormone-sensitive carcinomas has been reported. Our objective was to evaluate the expression of apoptosis-regulating genes Fas and FasL in Indian breast cancer and fibroadenoma patients in relation to hormone receptor status. STUDY DESIGN:Retrospective. MATERIALS AND M...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Ranade KJ,Nerurkar AV,Phulpagar MD,Shirsat NV

    更新日期:2012-01-01 00:00:00

  • Epidermal growth factor receptor mutation subtypes and geographical distribution among Indian non-small cell lung cancer patients.

    abstract:BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Choughule A,Noronha V,Joshi A,Desai S,Jambhekar N,Utture S,Thavamanni A,Prabhash K,Dutt A

    更新日期:2013-04-01 00:00:00

  • Gliomatosis cerebri--a case report.

    abstract::Gliomatosis cerebri is a vary rare neoplastic lesion of the central nervous system. An intra-vitam diagnosis of gliomatosis cerebri can be suggested with a steleolactic biopsy of the lesion in conjunction with Magnetic Resonance Imaging (MRI) findings in the brain. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Radhakrishnan VV,Misra BK,Rout D

    更新日期:1996-09-01 00:00:00

  • Community-based tobacco cessation program among women in Mumbai, India.

    abstract:BACKGROUND:Globally tobacco epidemic kills nearly six million people annually. Consumption of tobacco products is on the rise in low- and middle-income countries. Tobacco is addictive; hence, tobacco users need support in quitting. AIMS:Providing tobacco cessation services to women in community enabling them to quit t...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Mishra GA,Kulkarni SV,Majmudar PV,Gupta SD,Shastri SS

    更新日期:2014-12-01 00:00:00

  • Colloid cyst of the third ventricle: a cause of sudden death in a child.

    abstract::Colloid cyst is a rare benign intracranial neoplasm, commonly located in the third ventricle. Though headache and visual symptoms are classical, the patients may present with sudden neurological deterioration. We present a ten-year-old male child who presented with sudden neurological deterioration due to colloid cyst...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kava MP,Tullu MS,Deshmukh CT,Shenoy A

    更新日期:2003-01-01 00:00:00

  • Mature ovarian teratoma with gliomatosis peritonei--a case report.

    abstract::Gliomatosis peritonei (GP), a rare condition related to ovarian teratomas, is characterized by miliary implants of mature glial tissues on the peritoneum or omentum. We report herein a case of mature teratoma of the ovary with GP with imaging features and pathological correlation. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Das CJ,Sharma R,Thulkar S,Mukhopadhyay S,Deka D,Mannan R

    更新日期:2005-07-01 00:00:00

  • A prospective randomized trial comparing capecitabine-based chemoradiotherapy with 5-FU-based chemoradiotherapy in neoadjuvant setting in locally advanced carcinoma rectum.

    abstract:INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Singh K,Gupta MK,Seam RK,Gupta M

    更新日期:2017-01-01 00:00:00

  • Metachronous multicentric giant-cell tumour: a case report.

    abstract::Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Sadat-Ali M

    更新日期:1997-12-01 00:00:00

  • Primary plasmacytoma of testis. Report of a case.

    abstract::A primary testicular tumour in a 62 year old man was found to be a plasmacytoma on histopathological examination without any extra testicular disease prior to or subsequent to orchiectomy, fulfilling the criteria for the primary extramedullary plasmacytoma. Such cases are extremely rare. Evaluation of such a case was ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Reddi VR,Anne GP,Rani AV,Phaneendra BV,Ramesh O,Lakshmi N,Sekhar CC

    更新日期:1998-12-01 00:00:00

  • Time trend in frequency of occurrence of major immunophenotypes in paediatric acute lymphoblastic leukemia cases as experienced by Cancer Institute, Chennai, south India during the period 1989-2009.

    abstract:BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Rajalekshmy KR,Abitha AR,Anuratha N,Sagar TG

    更新日期:2011-07-01 00:00:00

  • Early diagnosis of cervical cancers. Our experience at the Rural Cancer Registry, Barshi, India.

    abstract::In the cervical cancer cases registered at the Cancer Hospital at Barshi, India during 1988-90, 99 of the 105 cases were clinically staged (Total number of cases registered: 136). The annual number of cases were too few for a comparison of stage distribution between the registry years. However, comparison of the propo...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Jayant K,Rao RS,Nene BM,Dale PS

    更新日期:1994-06-01 00:00:00

  • High potential of SOX21 gene promoter methylation as an epigenetic biomarker for early detection of colorectal cancer.

    abstract:Background:Despite the advances in screening during the past decades, colorectal cancer (CRC) still is a leading cause of cancer deaths worldwide. Therefore, the development of new diagnostic methods is necessary. Aim:The aim of this study was to compare methylation changes of SRY-Box 21 (SOX21) gene promoter in tumor...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Moradi K,Babaei E,Rezvani N,Safaralizadeh R,Bashiri H,Feizi MAH

    更新日期:2020-04-01 00:00:00

  • Applicability of RNA interference in cancer therapy: Current status.

    abstract::Cancer is a manifestation of dysregulated gene function arising from a complex interplay of oncogenes and tumor suppressor genes present in our body. Cancer has been constantly chased using various therapies but all in vain as most of them are highly effective only in the early stages of cancer. Recently, RNA interfer...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Maduri S

    更新日期:2015-01-01 00:00:00

  • Design, architecture and application of nanorobotics in oncology.

    abstract::Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Saxena S,Pramod BJ,Dayananda BC,Nagaraju K

    更新日期:2015-04-01 00:00:00

  • Serum haptoglobin level in patients with malignant lymphoma and its clinical significance.

    abstract::Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were als...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Desai SS,Ishwad CS,Balakrishnan V,Naik SN

    更新日期:1990-03-01 00:00:00

  • Juvenile nasopharyngeal angiofibroma: a single institution study.

    abstract:BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Mistry RC,Qureshi SS,Gupta S,Gupta S

    更新日期:2005-01-01 00:00:00

  • Artificial pneumothorax for pain relief during microwave ablation of subpleural lung tumors.

    abstract:BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Yang X,Zhang K,Ye X,Zheng A,Huang G,Li W,Wei Z,Wang J,Han X,Ni X,Meng M,Ni Y,Yuan Q,Xing C

    更新日期:2015-12-01 00:00:00

  • Patient profile and treatment outcome of rectal cancer patients treated with multimodality therapy at a regional cancer center.

    abstract:BACKGROUND:Incidence of rectal cancer has wide geographical variation. Disease pattern in developing countries is different from developed countries as majority of the patients present in advanced stage because of delayed referral and lack of uniform treatment practices. AIMS:Present study describes the patient profil...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Deo S,Kumar S,Shukla NK,Kar M,Mohanti BK,Sharma A,Raina V,Rath GK

    更新日期:2004-07-01 00:00:00

  • The founding of the Tata Memorial Hospital, 1932-1941.

    abstract::This article presents a brief account of the founding of the Tata Memorial Hospital. It draws upon archival material to show that this was not a mere philanthropic act but a scheme carefully thought-out by the Trustees of the Sir Dorabji Tata Trust. It discusses the major concerns of the Trustees as they deliberated u...

    journal_title:Indian journal of cancer

    pub_type: 历史文章,杂志文章


    authors: Kavadi SN

    更新日期:2019-07-01 00:00:00

  • Incidence and characteristics of Epidermal Growth Factor Receptor (EGFR) mutation in non-small-cell lung cancer (Adenocarcinoma histology): A report of 106 patients from Kolkata.

    abstract:CONTEXT:Regional epidemiological data regarding the epidermal growth factor receptor (EGFR) mutation status in non-small-cell lung cancers (NSCLC) is an unmet need from the eastern part of India. AIMS:To report the incidence of EGFR mutation and its correlation with the phenotypical characteristics, in NSCLC patients ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Chatterjee K,Ray A,Chattopadhyay B

    更新日期:2017-01-01 00:00:00

  • Primary lymphoma of breast--report of six cases and review of literature.

    abstract::Six patients of primary lymphoma of breast are presented. All our patients were female with median age of 46 years. Combination chemotherapy was the mainstay of treatment in all the patients. Five patients achieved complete remission of which two relapsed, one had a distant relapse and the other was local. Patient wit...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Dhabhar BN,Saikia TK,Soman CS,Advani SH

    更新日期:1992-09-01 00:00:00

  • Damage to the anterior visual pathway and brain parenchyma following external pituitary irradiation.

    abstract::Three cases of damage to the optic nerves and chiasma following pituitary irradiation with Co60 teletherapy are described. All of them presented with progressive visual impairment months following irradiation and simulated recurrence of the tumour. CT scan was also not helpful in differentiating radionecrosis from tum...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kundra SN,Sharma BS,Banerjee AK,Ayyagari S,Dhir SP,Kak VK

    更新日期:1990-09-01 00:00:00

  • Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.

    abstract:BACKGROUND:Ephrin A4 is one of the ephrin ligand molecules belonging to the tyrosine kinases receptor family. It was originally identified in a T-lymphoma cell line and seen to be expressed in human adult tissue as well as several tumor types. In our previous study, we showed the unique pattern of ephrin A4 immunohisto...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Abdou AG,Abd el-Wahed MM,Asaad NY,Samaka RM,Abdallaha R

    更新日期:2010-01-01 00:00:00