Abstract：
BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical effectiveness of CCT over monotherapy in patients with CRGNB. MATERIALS AND METHODS:We conducted a retrospective, observational study of patients with CRGNB bloodstream infections in our oncology and bone marrow transplant center. RESULTS:Over a 3-year study period (2011-2014), we could identify 91 patients satisfying study criteria. There was no statistically significant difference in the 28-day mortality between monotherapy and combination therapy arms (mono n = 26, mortality 10 (38.5%); combination n = 65, mortality 28 (40%); P = 0.886). Neutropenic patients with Enterobacteriaceae bloodstream infections performed better with combination therapy (mono n = 7, mortality 6 (85.7%); combination therapy n = 22, mortality 8 (36.4%); P = 0.035). There was no significant difference in the 28-day mortality between the two treatment arms in other subgroups. CONCLUSION:Our study did not find CCT superior to colistin monotherapy in patients with CRGNB blood stream infections; except in the subgroup of neutropenic patients with Enterobacteriaceae bloodstream infections, where combination therapy performed better.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Ghafur A,Devarajan V,Raja T,Easow J,Raja MA,Sreenivas S,Ramakrishnan B,Raman SG,Devaprasad D,Venkatachalam B,Nimmagadda Rdoi
10.4103/0019-509X.204767subject
Has Abstractpub_date
2016-10-01 00:00:00pages
592-594issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2016_53_4_592_204767journal_volume
53pub_type
杂志文章abstract：BACKGROUND:A relatively new development in the arena of prostatic histopathological study is the premalignant proliferative changes in the glandular epithelium, possibly relating to carcinoma. Two major categories have come up, namely prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (AAH)....
journal_title：Indian journal of cancer
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