Abstract：
PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions over 17 days followed by intracavitary brachytherapy. Forty-eight patients completed the planned treatment and were considered suitable for analysis of late reactions and survival. MAIN FINDINGS:The 5-year disease free survival was 59% and the overall survival was 50% at the mean follow up of 40 months. Twenty-one (44%) patients developed acute gastrointestinal toxicity of which 5 patients had grade III and one patient had grade IV reaction. Ten patients (21%) developed acute genitourinary complications, 13 patients (27%) had late rectal reactions and 10 patients (20%) had late bladder complications. Three patients had grade I, five had grade II and five had grade III late rectal toxicity. CONCLUSION:Survival in patients treated hypofractionated radiotherapy appears comparable to that of standard fractionation. The acute gastrointestinal and skin reactions were mainly grade I or grade II. Hypofractionated radiotherapy can certainly be considered in a select group of patients where the local disease is extensive and is unsuitable for conventional treatment.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Muckaden MA,Budrukkar AN,Tongaonkar HB,Dinshaw KAkeywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
127-34issue
4eissn
0019-509Xissn
1998-4774journal_volume
39pub_type
杂志文章abstract：:Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, the...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_455_19
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journal_title：Indian journal of cancer
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doi：10.4103/0019-509X.98938
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doi：10.4103/ijc.IJC_349_18
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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journal_title：Indian journal of cancer
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更新日期：1996-09-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.4103/0019-509X.204767
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journal_title：Indian journal of cancer
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.35810
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doi：10.4103/0019-509X.175569
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：10.4103/0019-509X.82875
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_19
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.15098
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
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pub_type： 杂志文章
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