Abstract：
Background:Gestational trophoblastic neoplasia (GTN) are a spectrum of tumors that develop from placental tissue. We aimed to evaluate the management and treatment outcome of GTN. Methods:Patients diagnosed with GTN presented to Kasr Alainy Center of Clinical Oncology between 2008 and 2017 were included in this study. Patients were assigned to low or high-risk according to the World Health Organization (WHO) scoring system. All data were tabulated and statistically studied by descriptive analysis; comparison between the two groups was done using student t-test for continuous data and Chi-square test for categorical data. Results:A total of 111 patients were studied; the majority of them had WHO low-risk score. In low-risk group, the overall response rate to methotrexate-folinic acid (MTX- FA) or actinomycin D (ActD) was 48.5%, comparable response rate observed between MTX and ActD was 48.2% vs 50%, respectively. Those who received MTX-FA 8-day regimen had higher response rate compared to a weekly schedule, however, no statistical significant difference was observed (51.6% vs 44.4%, respectively, P = 0.586), all low-risk patients who failed MTX or ActD achieved complete remission (CR) with subsequent chemotherapy. Patients with WHO score 5-6 had a significantly lower CR rate compared to patients with scores <5, (28% and 60%, respectively; P = 0.01). Five-years overall survival was significantly lower in high-risk than low-risk patients (79.3% vs 100%, respectively, P = <0.001). Conclusion:Low-risk patients have a survival rate of 100% even if they did not respond to first-line chemotherapy, MTX-FA 8-day regimen seems to be more effective than MTX weekly regimen.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Edesa WA,Ayad NN,Mounir AM,Haggag MHdoi
10.4103/ijc.IJC_551_19subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0019-509Xissn
1998-4774pii
297024pub_type
杂志文章abstract：:Secondary neoplasm of the thyroid mimicking a primary thyroid lesion is a rare finding, especially in an individual without a past history of malignancy. A case of squamous cell carcinoma metastatic to the thyroid (presenting as a solitary thyroid nodule), who had an unsuspected primary in the esophagus is described. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Ephrin A4 is one of the ephrin ligand molecules belonging to the tyrosine kinases receptor family. It was originally identified in a T-lymphoma cell line and seen to be expressed in human adult tissue as well as several tumor types. In our previous study, we showed the unique pattern of ephrin A4 immunohisto...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.58859
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.35810
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118732
更新日期：2013-07-01 00:00:00
abstract：:Cervical cancer is the leading malignancy among Indian women. It has been estimated that in the absence of any control programme, the incident number of cervical cancer cases in the country would rise to 140 thousand by the turn of this century. Cytology screening remains the main stay for the control of cervix cancer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Breast cancer is now the most common cancer in many parts of India and the incidence varies from 12 to 31/100,000, and is rising. Locally advanced breast cancer (LABC) accounts for 30-35% of all cases of breast cancers in India. LABC continues to present a challenge and imposes a major health impact in our c...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：10.4103/0019-509X.75838
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
abstract：:In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases includi...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.107735
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:Proteomics is increasingly employed in both neurological and oncological research, and applied widely in every area of neuroscience research including brain cancer. Astrocytomas are the most common glioma and can occur in most parts of the brain and occasionally in the spinal cord. Patients with high-grade...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.138271
更新日期：2014-04-01 00:00:00
abstract：:Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were als...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:A case report of a squamous cell carcinoma arising in a dermoid cyst of the ovary in a 29 year old patient is presented. Such an occurrence in young patients is unusual. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Background: Cervical cancer being a major cause of morbidity and mortality in women in developing countries, its awareness is essential. Aim: The aim of this study is to assess the knowledge, attitude and practices of women regarding the basic screening test for detection of cancer cervix. Settings and Design: Populat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146780
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.65316
更新日期：2010-07-01 00:00:00
abstract：Background:Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Methods:We explored the prevalence of ROS1, ALK, MET mutations, discu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_470_19
更新日期：2020-11-24 00:00:00
abstract：Background:Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods:Seventy patients diagn...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_19
更新日期：2020-12-10 00:00:00
abstract：:A rare case of pleomorphic intimal sarcoma of pulmonary trunk is reported. The patient presented with symptoms of right ventricular out flow tract (RVOT) obstruction. Metastatic deposits were seen in lungs, diaphragm and thyroid. Bronchial mucosal involvement was also seen. The tumour showed multicentric origin and on...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：CONTEXT:The most commonly prescribed conventional fractionation radiotherapy uses 1.8-2.2 Gy per fraction for five fractions in a week. Many times, unwanted interruptions are encountered, which ultimately affect the local control and overall survival. AIMS:The present retrospective study was carried out to study the c...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_517_17
更新日期：2018-04-01 00:00:00
abstract：:The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 an...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82901
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The product of Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.55550
更新日期：2009-10-01 00:00:00
abstract：:The use of colposcopy for follow up of patients with abnormal cervical smears has considerably increased the rate of detection of cervical malignancies and intraepithelial lesions in recent years. In case the lesion is situated high up in the cervical canal however, the chances of missing out the lesion are considerab...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:This note presents a brief account of the ideas and efforts of V.R. Khanolkar in the period 1952-1962 to develop the Indian Cancer Research Centre into a "center of excellence". Khanolkar, who is recognized as a pioneer in cancer research in India, focused on developing multidisciplinary medical research and mentored ...
journal_title：Indian journal of cancer
pub_type： 传,历史文章,杂志文章
doi：10.4103/ijc.IJC_14_19
更新日期：2019-10-01 00:00:00
abstract：:Human actinomycosis may pose a diagnostic problem at times and is often mistaken for a neoplasm. A thirty-five year old male was clinically diagnosed as a case of carcinoma of the right maxillary sinus on the basis of history, clinical presentation and radiologic findings. Tissue biopsy was negative for malignancy on ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Preoperative risk estimation evaluating mortality and morbidity might help surgical decision. AIMS:The aim of this study was to compare the sensitivities of physiologic and operative severity score for the enumeration of mortality and morbidity (POSSUM), portsmouth-POSSUM (P-POSSUM), colorectal-POSSUM (CR-P...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175318
更新日期：2014-10-01 00:00:00
abstract：:Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Nonsmall cell lung cancer is the leading cause of cancer mortality worldwide because of distant metastasis and frequent recurrence. Only few reliable and easily accessible tumor markers have been clinically implemented to the early nonsmall cell cancer prognosis. OBJECTIVE:The purpose of this study is to de...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.172509
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175332
更新日期：2014-10-01 00:00:00
abstract：:Cancer is a manifestation of dysregulated gene function arising from a complex interplay of oncogenes and tumor suppressor genes present in our body. Cancer has been constantly chased using various therapies but all in vain as most of them are highly effective only in the early stages of cancer. Recently, RNA interfer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175598
更新日期：2015-01-01 00:00:00
abstract：:Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_260_18
更新日期：2018-07-01 00:00:00
abstract：INTRODUCTION:This study was undertaken to evaluate the clinicopathological characteristics of patients with breast cancer at our institute, a tertiary-care cancer center in northern India. MATERIALS AND METHODS:This retrospective study included all patients with breast cancer registered at our institute from January 1...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_73_18
更新日期：2018-07-01 00:00:00
