Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.

Abstract:

BACKGROUND:Ephrin A4 is one of the ephrin ligand molecules belonging to the tyrosine kinases receptor family. It was originally identified in a T-lymphoma cell line and seen to be expressed in human adult tissue as well as several tumor types. In our previous study, we showed the unique pattern of ephrin A4 immunohistochemical staining, which differed according to the type of examined bone specimens (normal bone, primary, and metastatic osteosarcoma lesions). The aim of the present study is to evaluate the prognostic impact of ephrin A4 expression in a group of primary osteosarcoma patients. MATERIALS AND METHODS:Ephrin A4 immunohistochemical expression was carried out on 47 primary osteosarcoma cases. RESULTS:Ephrin A4 was expressed in 82.9% of osteosarcoma cases with cytoplasmic localization in 58.9% of positive cases. The cytoplasmic pattern was significantly associated with aggressive histopathological types of osteosarcoma (P = 0.02), advanced stage (P = 0.04), the presence of metastasis (P = 0.03), inferior response to neoadjuvent chemotherapy (P = 0.04), and tended to be associated with a shorter event-free survival (P = 0.09). CONCLUSIONS:The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Abdou AG,Abd el-Wahed MM,Asaad NY,Samaka RM,Abdallaha R

doi

10.4103/0019-509X.58859

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

46-52

issue

1

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2010_47_1_46_58859

journal_volume

47

pub_type

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