Abstract:
BACKGROUND:Ephrin A4 is one of the ephrin ligand molecules belonging to the tyrosine kinases receptor family. It was originally identified in a T-lymphoma cell line and seen to be expressed in human adult tissue as well as several tumor types. In our previous study, we showed the unique pattern of ephrin A4 immunohistochemical staining, which differed according to the type of examined bone specimens (normal bone, primary, and metastatic osteosarcoma lesions). The aim of the present study is to evaluate the prognostic impact of ephrin A4 expression in a group of primary osteosarcoma patients. MATERIALS AND METHODS:Ephrin A4 immunohistochemical expression was carried out on 47 primary osteosarcoma cases. RESULTS:Ephrin A4 was expressed in 82.9% of osteosarcoma cases with cytoplasmic localization in 58.9% of positive cases. The cytoplasmic pattern was significantly associated with aggressive histopathological types of osteosarcoma (P = 0.02), advanced stage (P = 0.04), the presence of metastasis (P = 0.03), inferior response to neoadjuvent chemotherapy (P = 0.04), and tended to be associated with a shorter event-free survival (P = 0.09). CONCLUSIONS:The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Abdou AG,Abd el-Wahed MM,Asaad NY,Samaka RM,Abdallaha Rdoi
10.4103/0019-509X.58859subject
Has Abstractpub_date
2010-01-01 00:00:00pages
46-52issue
1eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2010_47_1_46_58859journal_volume
47pub_type
杂志文章abstract::Activating mutations in the epidermal growth factor receptor gene and rearrangement of the anaplastic lymphoma kinase gene exemplify the molecular characterization of nonsmall cell lung cancer (NSCLC), particularly adenocarcinoma, and its therapeutic relevance. Several genetic alterations with prognostic and predictiv...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/ijc.IJC_258_17
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:This retrospective study was performed in a tertiary care center from India analyzing the histopathological reports and the clinical data of the adult patients admitted in this institute with a diagnosis of renal tumors and had undergone nephrectomy for the disease. OBJECTIVE:The objective of this study is ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.180837
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.84932
更新日期:2011-07-01 00:00:00
abstract::Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were als...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) derived from Plumbago species is a potential anti-tumour agent. Plumbagin has been tested for anti-cancer activity in vitro and in vivo using mice model. AIM:To study the tumour suppressing efficacy of plumbagin using zebrafish model. MATERIALS AND METHODS:H...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.219580
更新日期:2017-01-01 00:00:00
abstract::Meticulous staging of ovarian cancer has so far been a prerequisite for treatment planning. However, more than 80% of patients operated by non-oncologists all over the world do not under go a complete staging. Recently there have been reports questioning the need for extensive staging from the point of cervical benefi...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Primary undifferentiated embryonal of the liver in children is a rare neoplasm with dismal prognosis. Surgery is the treatment of choice. Adjuvant chemotherapy may prove useful in improving the prognosis of these tumours. We report two cases of Primary undifferentiated embryonal sarcoma of the liver. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Preoperative risk estimation evaluating mortality and morbidity might help surgical decision. AIMS:The aim of this study was to compare the sensitivities of physiologic and operative severity score for the enumeration of mortality and morbidity (POSSUM), portsmouth-POSSUM (P-POSSUM), colorectal-POSSUM (CR-P...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175318
更新日期:2014-10-01 00:00:00
abstract::Cancer is a manifestation of dysregulated gene function arising from a complex interplay of oncogenes and tumor suppressor genes present in our body. Cancer has been constantly chased using various therapies but all in vain as most of them are highly effective only in the early stages of cancer. Recently, RNA interfer...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.175598
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Breast cancer is now the most common cancer in many parts of India and the incidence varies from 12 to 31/100,000, and is rising. Locally advanced breast cancer (LABC) accounts for 30-35% of all cases of breast cancers in India. LABC continues to present a challenge and imposes a major health impact in our c...
journal_title:Indian journal of cancer
pub_type: 临床试验,杂志文章
doi:10.4103/0019-509X.75838
更新日期:2011-01-01 00:00:00
abstract::The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 an...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:CONTEXT:Cancer profile varies in different regions and depends on race, lifestyle and diet. The study of a cancer profile helps to know the common cancers in a particular population, its probable risk factors and also helps in cancer control programs. AIM:To study the cancer profile at Kolar, based on Pathology Depart...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.63011
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.104499
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.175332
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Lymphedema following breast cancer treatment is one of the most morbid conditions affecting breast cancer survivors. Currently, no therapy completely cures this condition. Comprehensive Decongestive Therapy (CDT), a novel physiotherapeutic method offers promising results in managing this condition. This ther...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.92250
更新日期:2011-10-01 00:00:00
abstract::We present an interesting case of port site metastasis is a menopausal women subsequent to diagnostic laparoscopy undertaken for chronic pelvic pain, which later proved early ovarian malignancy as the source of primary. While cases of port site metastasis have mostly occurred after extensive disease the possbility of ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The use of cell phones is increasing worldwide at a phenomenal pace. While cellular communication has dramatically influenced our lifestyle, its impact on human health has not been completely assessed. Widespread concern continues in the community about the deleterious effects of radiofrequency radiations (with which ...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509x.48589
更新日期:2009-01-01 00:00:00
abstract::Six patients of primary lymphoma of breast are presented. All our patients were female with median age of 46 years. Combination chemotherapy was the mainstay of treatment in all the patients. Five patients achieved complete remission of which two relapsed, one had a distant relapse and the other was local. Patient wit...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
abstract::Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Esophageal cancer (EC) is one of the most frequent and serious cancers worldwide, but its geographic distribution is disparate. Northern Iran is known as one of the hot spots for EC, but there is inadequate evidence available regarding its characteristics in northwestern region of Iran. Therefore, this study...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.82875
更新日期:2011-04-01 00:00:00
abstract::This note presents a brief account of the ideas and efforts of V.R. Khanolkar in the period 1952-1962 to develop the Indian Cancer Research Centre into a "center of excellence". Khanolkar, who is recognized as a pioneer in cancer research in India, focused on developing multidisciplinary medical research and mentored ...
journal_title:Indian journal of cancer
pub_type: 传,历史文章,杂志文章
doi:10.4103/ijc.IJC_14_19
更新日期:2019-10-01 00:00:00
abstract::The office of the Drugs Controller General (India) vide order dated 19 th November 2013 has made audio visual (AV) recording of the informed consent mandatory for the conduct of all clinical trials in India. We therefore developed a standard operating procedure (SOP) to ensure that this is performed in compliance with...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.138158
更新日期:2014-04-01 00:00:00
abstract::Over the past few decades, considerable success has been achieved in the field of cancer treatment with biological response modifiers (BRM), which are agents that improve the body's ability to fight cancer by immunostimulation. Biological agents, such as interferons and interleukins, provide nonspecific active immunit...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.73559
更新日期:2010-10-01 00:00:00
abstract::This article presents a brief account of the founding of the Tata Memorial Hospital. It draws upon archival material to show that this was not a mere philanthropic act but a scheme carefully thought-out by the Trustees of the Sir Dorabji Tata Trust. It discusses the major concerns of the Trustees as they deliberated u...
journal_title:Indian journal of cancer
pub_type: 历史文章,杂志文章
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更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Metaplastic breast carcinoma (MBC) is a rare disease with incidence of less than 1%. MBC present with a larger tumor size, less number of nodes involved, mostly undifferentiated triple negative tumors. We aimed to determine progression-free and overall survival and reported hospital-based incidence of MBC. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_731_18
更新日期:2019-04-01 00:00:00
abstract::Casual Interpretation of results in a given article has several pitfalls. In order to assess the strengths and limitations of a given article several factors need to be considered. This review article is intended to list, classify and describe briefly the factors that should be considered in the evaluation of an artic...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.35810
更新日期:2007-04-01 00:00:00
abstract::Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Isolated central nervous metastasis is rare in patients with Ewing's sarcoma. Here we report two cases with CNS metastasis as the sole manifestation of relapse with a brief review of the literature. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00