Abstract：
BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development of cancer through DNA damage. MATERIALS AND METHODS:Here we ascertained the various oxidative stress determinants in diagnosed SCCHN patients with health risk addictions. This study further evaluated the incremental effects inflicted by these lifestyle factors on redox status. The study included 100 consenting SCCHN patients and 90 matched healthy controls. Salivary total antioxidant capacity (TAC), glutathione (GSH), free radicals: such as reactive nitrogen species (RNS) and reactive oxygen species (ROS) along with oxidative DNA adduct (8-OHdG) were monitored. RESULTS:Our findings indicated altered salivary oxidant-antioxidant status in SCCHN. A substantial rise in ROS (~2.0 folds) and RNS (~1.4 folds), together with significant lowering in TAC (~1.2 folds) and GSH (~1.7 folds) was observed. The 8-OHdG levels were also found to be considerably higher (P < 0.001) in salivary cell's DNA of these patients. CONCLUSIONS:Our results demonstrate significant redox imbalance in cancer patients suggesting their paramount importance in the development of SCCHN.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Kumar A,Pant MC,Singh HS,Khandelwal Sdoi
10.4103/0019-509X.104499subject
Has Abstractpub_date
2012-07-01 00:00:00pages
309-15issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2012_49_3_309_104499journal_volume
49pub_type
杂志文章abstract：OBJECTIVE:The deregulation of microRNA-185 (miR-185) has been showed to be associated with many cancers and act as a tumor suppressor in many types of human malignancies. We hence tried to find out its role in human colorectal cancer (CRC). MATERIALS AND METHODS:miR-185 expression was investigated by real-time quantit...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.186576
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Historically, metastatic renal cell carcinoma (RCC) has had poor prognosis; the outcomes have improved with the introduction of tyrosine-kinase inhibitors, such as sunitinib. There is no reported literature from India on the use of sunitinib in metastatic RCC. We present an analysis of sunitinib at our ins...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118725
更新日期：2013-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176715
更新日期：2015-07-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.172519
更新日期：2015-12-01 00:00:00
abstract：:A total of forty bone marrow trephine biopsies and aspirates were studied from thirty five patients suffering from Hodgkin's disease during the two year period 1994 and 1995. Of these twenty five were at the time of diagnosis of the disease and fifteen after treatment. The biopsies were studied for incidence of involv...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：10.4103/0019-509X.75816
更新日期：2011-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175318
更新日期：2014-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 传,历史文章,杂志文章
doi：10.4103/ijc.IJC_14_19
更新日期：2019-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.35810
更新日期：2007-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.138271
更新日期：2014-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.180837
更新日期：2016-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197725
更新日期：2016-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_466_17
更新日期：2018-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82901
更新日期：2011-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_258_17
更新日期：2017-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.41772
更新日期：2008-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175579
更新日期：2015-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.76625
更新日期：2011-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175805
更新日期：2015-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
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journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175332
更新日期：2014-10-01 00:00:00
abstract：:Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series fro...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_499_17
更新日期：2017-10-01 00:00:00
