Chylothorax in children with cancer: A milky predicament.

Abstract:

:Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series from a pediatric hematology-oncology unit. Chylothorax was diagnosed by demonstrating high triglyceride content in the pleural fluid and a low cholesterol concentration in relation to the serum cholesterol. Cytology for malignant cells and investigations for tuberculosis were performed in all patients. Initial management included placement of an intercostal tube and administration of a fat-free diet with the addition of medium-chain triglycerides. Appropriate treatment of the underlying malignancy was initiated simultaneously. Three children with diagnoses of Stage IV neuroblastoma, lymphoblastic lymphoma, and Hodgkin lymphoma developed chylothorax. Malignant cytology was positive in the patient with T-NHL. All patients were found to have associated hypoproteinemia and hypoalbuminemia. The chylothorax resolved with conservative measures in two patients. It remained intractable in the child with T-NHL, in whom the lymphoma was refractory to chemotherapy. Chylothorax is a rare but challenging complication that can accompany childhood malignancies. Surgical interventions, radiotherapy, and pleurodesis are alternatives if the chylothorax is refractory to medical management.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Totadri S,Trehan A,Bhattacharya A,Bansal D,Attri SV,Srinivasan R

doi

10.4103/ijc.IJC_499_17

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

691-694

issue

4

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2017_54_4_691_237903

journal_volume

54

pub_type

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