Abstract：
AIMS:The aim of this study is to investigate the activity and toxicity of etoposide with AUC 6 doses of carboplatin in patients with previously untreated extensive disease - small-cell lung cancer (SCLC). MATERIALS AND METHODS:88 eligible patients were treated with chemotherapy comprised of carboplatin AUC of 6, IV day 1 and etoposide 100 mg/m 2 , IV day 1-3. This schedule was repeated every 21 days for maximum of six cycles. RESULTS:Patients characteristics: Median age, 62 years; 84 male; ECOG PS 0-1 in 73 patients, PS 2-3 in 15 patients. A total of 431 cycles were administered (median, 6.0). The complete and partial response rates were 23.9% and 45.5%, respectively. Median overall survival (OS) was 9.0 months (95% confidence interval [CI], 8.09 - 9.90 m); 84 patients died. The 1- and 2-year survival probabilities were 33.6% and 5.3%, respectively. The median progression-free survival in patients of 65 was 7.2 months (95% CI, 5.81 - 8.58), 12-month PFS rate was 10%. The median OS was 11.6 months (95% CI, 8.52 - 14.67 m) and 7.5 months (95% CI, 5.61 - 9.38 m) in patients with non-liver and liver metastasis, respectively (P = 0.024). The median OS was 9.3 months (95% CI, 7.83 - 10.76 m) and 7.5 months (95% CI, 5.58 - 9.44 m) in patients with single and multiple distant metastasis, respectively (P = 0.02). Grade 3-4 neutropenia, thrombocytopenia, and anemia were detected in 57.9%, 15.9%, and 11.4% of patients, respectively. Febrile neutropenia was developed in 12 patients. CONCLUSION:Etoposide with AUC 6 doses of carboplatin is active and tolerable in patients with extensive disease - SCLC.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Yilmaz U,Polat G,Anar C,Halilcolar Hdoi
10.4103/0019-509X.92279subject
Has Abstractpub_date
2011-10-01 00:00:00pages
454-9issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2011_48_4_454_92279journal_volume
48pub_type
杂志文章abstract：BACKGROUND:Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) derived from Plumbago species is a potential anti-tumour agent. Plumbagin has been tested for anti-cancer activity in vitro and in vivo using mice model. AIM:To study the tumour suppressing efficacy of plumbagin using zebrafish model. MATERIALS AND METHODS:H...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.219580
更新日期：2017-01-01 00:00:00
abstract：:Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.178403
更新日期：2015-10-01 00:00:00
abstract：:The procedure of facial resurfacing dictates that there should be an excellent colour and texture match between the facial and the transposed skin. Cervical flaps e.g. platysma flap are commonly used for reconstruction of facial defects but, with disadvantages like limited mobility, unacceptable donor site and unpredi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:5-Fluorouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the r...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：10.4103/0019-509X.75816
更新日期：2011-01-01 00:00:00
abstract：CONTEXT:Use of neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) enables tumor reduction and conservative surgery. It is proposed in some studies that there may be an alteration in the hormonal receptor (HR) status and human epidermal growth factor receptor 2 (Her-2)/neu immune-expression followi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200669
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The product of Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.55550
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma (MM) characterized by a fulminant course and poor prognosis. Flow cytometry (FCM) is very useful in the diagnosis of the plasma cell leukemia. Herein, we present 10 cases of PCL. MATERIALS AND METHODS:We retrospectively studied immu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134605
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:There is limited Indian data on clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung. AIM:We aimed to prospectively study the clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung at a tertiary cancer center. MATERIALS AND METHODS:One...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.219595
更新日期：2017-01-01 00:00:00
abstract：:Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, the...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_455_19
更新日期：2019-11-01 00:00:00
abstract：Background:Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods:Seventy patients diagn...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_19
更新日期：2020-12-10 00:00:00
abstract：:Twenty five patients of advanced breast cancer (Stage IIIb and IV) were studied and the histological changes following chemotherapy were looked. All the tumours showed varying degree of histological changes. Twenty eight percent tumours showed Grade I changes, 28 percent had Grade II changes and 28 percent had Grade I...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Globally tobacco epidemic kills nearly six million people annually. Consumption of tobacco products is on the rise in low- and middle-income countries. Tobacco is addictive; hence, tobacco users need support in quitting. AIMS:Providing tobacco cessation services to women in community enabling them to quit t...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.147474
更新日期：2014-12-01 00:00:00
abstract：AIMS:Volumetric modulated arc radiotherapy (VMAT) is used for inoperable, locally advanced nonsmall cell lung cancer, where three-dimensional conformal radiotherapy (3D-CRT) cannot yield an acceptable plan. METHODS:The planning and treatment data were prospectively collected on the first 18 patients treated using VMAT...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_79_17
更新日期：2017-01-01 00:00:00
abstract：:The office of the Drugs Controller General (India) vide order dated 19 th November 2013 has made audio visual (AV) recording of the informed consent mandatory for the conduct of all clinical trials in India. We therefore developed a standard operating procedure (SOP) to ensure that this is performed in compliance with...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.138158
更新日期：2014-04-01 00:00:00
abstract：:The practice of radiation oncology requires stringent adherence to specific steps and principles designed to minimize exposure of an individual to unnecessary doses of radiation. The basic principles of such measures to reduce the risk of exposure and limit the doses of irradiation follow the "as low as reasonably ach...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_343_20
更新日期：2020-04-01 00:00:00
abstract：:The clinical microbiology department at CMC&H, Vellore in conjunction with the haematology department carries out routine surveillance of patients admitted to the hematology department. Since 1994 in a sample population of 55 patients with various underlying clinical conditions who have had bone marrow transplant, sep...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors incl...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.76625
更新日期：2011-01-01 00:00:00
abstract：PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions o...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:The use of colposcopy for follow up of patients with abnormal cervical smears has considerably increased the rate of detection of cervical malignancies and intraepithelial lesions in recent years. In case the lesion is situated high up in the cervical canal however, the chances of missing out the lesion are considerab...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Wide resection of bone tumour has become an accepted treatment in the limb salvage surgery. The reconstruction of the residual defect following wide resection is a major problem. The motions of involved joint after resection of the large tumour can be restored by using either the osteoarticular allograft or endoprosth...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:Resection or loss of a portion of the mandible can result in a variety of functional, cosmetic and psychological deficits that are dependent on the extent of the defect, the concomitant therapy and the timing of rehabilitative efforts. These impairments greatly affect the patient's Quality of life (QOL). The thrust in...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.112282
更新日期：2013-01-01 00:00:00
abstract：:Neuroendocrine tumors, including carcinoids account for less than 1% of gastric tumors. Various subtypes of gastric carcinoids have been reported earlier. The present case deals with two unusual presentations, diagnosis and course of a gastric neuroendocrine tumor in an adult patient. A 35-years-old male initially pre...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.16700
更新日期：2005-04-01 00:00:00
abstract：AIM OF STUDY:To investigate the trend of expression of liver function test enzymes and other biochemical changes during gallbladder carcinogenesis. MATERIALS AND METHODS:Eight hundred and seventy-eight gallbladder disease patients were selected to study the liver function test enzymes and routine blood biochemical cha...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.98938
更新日期：2012-01-01 00:00:00
abstract：:Three cases of damage to the optic nerves and chiasma following pituitary irradiation with Co60 teletherapy are described. All of them presented with progressive visual impairment months following irradiation and simulated recurrence of the tumour. CT scan was also not helpful in differentiating radionecrosis from tum...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.123611
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.25773
更新日期：2006-01-01 00:00:00
abstract：:The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 an...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:L-asparaginase is a valuable chemotherapeutic agent used in the induction of remission and improvement of long term survival in patients with acute lymphoblastic leukemia. Hyperglycemia is a well known side effect of L-asparaginase. Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblas...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Wilms' tumor 1 (WT1) mutation has recently been detected in gliomas. Growing data indicate that WT1 mutation plays a causal role in gliomagenesis and is overexpressed in most glioblastomas. An emerging immunotherapy targeting WT1 has shown to be effective in resistant glioblastomas in clinical trials. WT1 ex...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_51_18
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.49154
更新日期：2009-04-01 00:00:00
