Abstract：
:Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, their limited potential to cross the blood-brain barrier (BBB) renders them less effective in the management of CNS metastases in NSCLC. Osimertinib, a third-generation irreversible EGFR-TKI with good potential to cross the BBB, has shown significant clinical activity and acceptable safety profile in patients with EGFR-positive NSCLC brain and leptomeningeal metastases. The progression-free survival (PFS) of up to 15.2 months in CNS metastases patients in the FLAURA trial and the CNS objective response rates (ORRs) of 54% and 43% in the AURA/AURA2 and BLOOM trials, respectively, have established the role of osimertinib in patients with NSCLC with CNS metastases. The AURA3 trial also reported a PFS of 8.5 months and overall ORR of 71%. These data have supported osimertinib to be recognized as a "preferred" first-line treatment for EGFR-positive metastatic NSCLC by the National Comprehensive Cancer Network (NCCN). With limited treatment options available, upfront administration of osimertinib in patients with NSCLC irrespective of EGFR T790M and CNS metastases may improve the overall response rate and potentially reduce the adverse effects of radiotherapy. Our review focuses on the management of EGFR-mutated NSCLC CNS metastases in the context of recent NCCN guidelines.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Shetty V,Babu Sdoi
10.4103/ijc.IJC_455_19subject
Has Abstractpub_date
2019-11-01 00:00:00pages
S31-S37issue
Supplementeissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2019_56_5_31_272014journal_volume
56pub_type
杂志文章,评审abstract：INTRODUCTION:: Indian families are known for adopting the role of caregiver naturally when someone in the family falls ill to cancer. Although there were strong family structure and system existed here, now the changing family pattern and structure are challenging the role of cancer caregiving as well. OBJECTIVE:: Thi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_211_17
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:This study aimed to evaluate the outcome of benign vocal cord tumors treated using a laryngeal endoscopy under low temperature-controlled radiofrequency and to elucidate the application of a dynamic laryngoendoscopy in the operation. MATERIALS AND METHODS:85 patients with benign vocal cord tumors were treate...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151994
更新日期：2015-02-01 00:00:00
abstract：:Activating mutations in the epidermal growth factor receptor gene and rearrangement of the anaplastic lymphoma kinase gene exemplify the molecular characterization of nonsmall cell lung cancer (NSCLC), particularly adenocarcinoma, and its therapeutic relevance. Several genetic alterations with prognostic and predictiv...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/ijc.IJC_258_17
更新日期：2017-01-01 00:00:00
abstract：:The office of the Drugs Controller General (India) vide order dated 19 th November 2013 has made audio visual (AV) recording of the informed consent mandatory for the conduct of all clinical trials in India. We therefore developed a standard operating procedure (SOP) to ensure that this is performed in compliance with...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.138158
更新日期：2014-04-01 00:00:00
abstract：:Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Non-urothelial bladder tumors (NUBTs) are uncommon accounting for approximately 10% of the total urinary bladder tumors while 90% are urothelial in origin. There are very limited comprehensive studies on NUBTs. AIMS AND OBJECTIVES:The objectives of the study were to analyze the clinicopathological and immun...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_17
更新日期：2019-07-01 00:00:00
abstract：PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions o...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.172519
更新日期：2015-12-01 00:00:00
abstract：:Five cases of primary lymphoma of the brain are reported and the literature reviewed. The diverse clinical spectrum at presentation and variable response to therapy are few of its unique features. The literature is reviewed briefly and the importance of diagnosis at an early stage and prompt institution of therapy in ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:There is limited Indian data on clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung. AIM:We aimed to prospectively study the clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung at a tertiary cancer center. MATERIALS AND METHODS:One...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.219595
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.25773
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Preoperative risk estimation evaluating mortality and morbidity might help surgical decision. AIMS:The aim of this study was to compare the sensitivities of physiologic and operative severity score for the enumeration of mortality and morbidity (POSSUM), portsmouth-POSSUM (P-POSSUM), colorectal-POSSUM (CR-P...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175318
更新日期：2014-10-01 00:00:00
abstract：:Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the report...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Uncommon patterns of presentation of acute leukemia pose diagnostic problems. A rheumatological prodrome in acute myeloblastic leukemia is very rare. We describe one such patient who had a normal haemogram. Bone marrow examination done later revealed acute myeloblastic leukemia. The case is discussed with reference to...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Ten patients of the advanced malignant germ cell tumours of the ovary were treated by cisplatin based combination chemotherapy after initial conservation surgery. Eight patients completed course containing cisplatinum, vinblastine and bleomycin. Five patients (62.5%) achieved CR while 2 (25%) attained PR. One patient ...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：Background:Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Methods:We explored the prevalence of ROS1, ALK, MET mutations, discu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_470_19
更新日期：2020-11-24 00:00:00
abstract：Background:Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods:Seventy patients diagn...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_19
更新日期：2020-12-10 00:00:00
abstract：:Neuroendocrine tumors, including carcinoids account for less than 1% of gastric tumors. Various subtypes of gastric carcinoids have been reported earlier. The present case deals with two unusual presentations, diagnosis and course of a gastric neuroendocrine tumor in an adult patient. A 35-years-old male initially pre...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.16700
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82901
更新日期：2011-04-01 00:00:00
abstract：:Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mu...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_545_17
更新日期：2017-12-01 00:00:00
abstract：:Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were als...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：CONTEXT:Regional epidemiological data regarding the epidermal growth factor receptor (EGFR) mutation status in non-small-cell lung cancers (NSCLC) is an unmet need from the eastern part of India. AIMS:To report the incidence of EGFR mutation and its correlation with the phenotypical characteristics, in NSCLC patients ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_239_17
更新日期：2017-01-01 00:00:00
abstract：:We have studied fibrinolytic activity of 12 cases of infiltrating duct carcinoma of breast (7 metastatic and 5 non-metastatic) and ten cases of adenocarcinoma of gastrointestinal tract (5 each of metastatic and nonmetastatic), and compared with some of their normal tissue counterparts. Both metastatic and non-metastat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146774
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma (MM) characterized by a fulminant course and poor prognosis. Flow cytometry (FCM) is very useful in the diagnosis of the plasma cell leukemia. Herein, we present 10 cases of PCL. MATERIALS AND METHODS:We retrospectively studied immu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134605
更新日期：2014-01-01 00:00:00
abstract：:Background: Cervical cancer being a major cause of morbidity and mortality in women in developing countries, its awareness is essential. Aim: The aim of this study is to assess the knowledge, attitude and practices of women regarding the basic screening test for detection of cancer cervix. Settings and Design: Populat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146780
更新日期：2014-07-01 00:00:00
abstract：:The utility of computed tomography in pretherapy assessment of esophageal carcinoma is reviewed. Computed tomographic findings in 78 patients with histologically proved esophageal carcinoma were corelated with findings at surgery and histopathology. Computed tomography (CT) was found to be fairly accurate in assessing...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
