Clinical utility of ketoconazole in cases of adrenocortical carcinoma.

Abstract:

:Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Harinarayan CV,Gupta S,Ammini AC,Karmarkar MG,Gupta R,Sharma LK,Ahuja MM

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

196-201

issue

4

eissn

0019-509X

issn

1998-4774

journal_volume

28

pub_type

杂志文章
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  • Efficacy of second-line erlotinib in patients postprogression of first-line chemotherapy in head and neck cancers.

    abstract:BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treat...

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    doi:10.4103/0019-509x.25773

    authors: Raina V,Sharma A,Vora A,Shukla NK,Deo SV,Dawar R

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    doi:

    authors: Singh ZN,Ray R,Karak AK,Chopra P

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  • Assessment of chlorpromazine as radiation sensitizer and protector.

    abstract::In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the ce...

    journal_title:Indian journal of cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Huilgol NG,Chatterjee N,Singh BB

    更新日期:1996-12-01 00:00:00

  • Gastric outlet obstruction and cutaneous metastasis in adenocarcinoid tumor of stomach - unusual presentations with cytologic and ultra structural findings.

    abstract::Neuroendocrine tumors, including carcinoids account for less than 1% of gastric tumors. Various subtypes of gastric carcinoids have been reported earlier. The present case deals with two unusual presentations, diagnosis and course of a gastric neuroendocrine tumor in an adult patient. A 35-years-old male initially pre...

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    更新日期:2005-04-01 00:00:00

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    journal_title:Indian journal of cancer

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    journal_title:Indian journal of cancer

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    doi:

    authors: Kava MP,Tullu MS,Deshmukh CT,Shenoy A

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  • Monotherapy versus combination therapy against carbapenem-resistant Gram-negative bacteria: A retrospective observational study.

    abstract:BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical eff...

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    doi:10.4103/0019-509X.204767

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    更新日期:2016-10-01 00:00:00

  • Selective internal radiation therapy: 90Y (yttrium) labeled microspheres for liver malignancies (primary and metastatic).

    abstract::Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors incl...

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    更新日期:2011-01-01 00:00:00

  • Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines.

    abstract:INTRODUCTION:Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulf...

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    authors: Nageshwari B,Merugu R

    更新日期:2017-07-01 00:00:00

  • Importance of repeat tissue biopsy and tissue-based epidermal growth factor receptor T790M testing in progressed nonsmall cell lung carcinoma patients upon negative plasma genotyping for selection of third-generation tyrosine kinase inhibitor therapy: A c

    abstract::Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mu...

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    doi:10.4103/ijc.IJC_545_17

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  • Study of the RET gene and his implication in thyroid cancer: Morocco case family.

    abstract:BACKGROUND:Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that affects multiple tissues derived from the neural crest. Inheritance of MTC is related to the presence of specific mutations in the RET proto-oncogene. Almost all mutations in MEN 2A involve one of the cystei...

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    doi:10.4103/0019-509x.27934

    authors: Ainahi A,Kebbou M,Timinouni M,Benabdeljalil N,Fechtali T,Oufara S,El Antri S

    更新日期:2006-07-01 00:00:00

  • FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry 'Equivocal' interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center expe

    abstract:Background:Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Methods:We explored the prevalence of ROS1, ALK, MET mutations, discu...

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  • Concomitant RAS and BRAF mutation in colorectal cancer - A report of 7 cases.

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  • Integrated positron emission tomography/computed tomography fusion imaging: an emerging gold standard in lung cancer.

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  • Retrospective audit of clinico-pathologic features and treatment outcomes in a cohort of elderly non-Hodgkin's lymphoma patients in a tertiary cancer center.

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    doi:10.4103/0019-509X.178434

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  • Proteomics analysis of human brain glial cell proteome by 2D gel.

    abstract:INTRODUCTION:Proteomics is increasingly employed in both neurological and oncological research, and applied widely in every area of neuroscience research including brain cancer. Astrocytomas are the most common glioma and can occur in most parts of the brain and occasionally in the spinal cord. Patients with high-grade...

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    pub_type: 杂志文章

    doi:10.4103/0019-509X.138271

    authors: Pooladi M,Abad SK,Hashemi M

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  • Clinicopathological profile of breast cancer: An institutional experience.

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  • Screening for cancer of uterine cervix and approaches adopted in India.

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    journal_title:Indian journal of cancer

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    authors: Murthy NS,Mathew A

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    journal_title:Indian journal of cancer

    pub_type: 杂志文章

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