Abstract：
INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue compared with healthy tissue. As an oral agent, capecitabine can be administered in the outpatient setting, potentially providing FU exposure similar to a lowdose continuous infusion of 5FU. AIMS AND OBJECTIVES:To compare capecitabine with 5FU, with regard to efficacy and toxicity when used in neoadjuvant setting along with radiotherapy for locally advanced carcinoma rectum. MATERIALS AND METHODS:Thirty patients were enrolled, 14 in 5FU and 16 in capecitabine arm. All patients were planned for 45 Gy/25#/5 weeks pelvic radiotherapy followed by a boost of 5.4 Gy/3#/3 days. 5FU was prescribed at a dose of 500 mg/m2 #1-#5 and #21-#25 of RT and capecitabine was given at 1650 mg/m2 on RT days throughout the course of radiotherapy. A magnetic resonance imaging/computerized tomography scan was done at the start of treatment and 1 month after completion of treatment, followed by surgery. Toxicity was assessed weekly during treatment and on the first followup. RESULTS:Response rates and toxicity profile of capecitabinebased cathode ray tube (CRT) was similar to 5FUbased CRT with nonsignificant P values. CONCLUSION:Capecitabine may be used as an alternative in patients who do not tolerate 5FU.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Singh K,Gupta MK,Seam RK,Gupta Mdoi
10.4103/ijc.IJC_174_17subject
Has Abstractpub_date
2017-01-01 00:00:00pages
347-351issue
1eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2017_54_1_347_219554journal_volume
54pub_type
杂志文章,随机对照试验abstract：:Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Thre...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:A case of low grade hemangiopericytoma of three years duration occurring in the upper end of the femur of a 70 year old man is described. Radiologically, the upper third of the right femur showed a destructive expansile osteolytic lesion with soft tissue extension. The tumour was partially encapsulated. Mitoses were 0...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：INTRODUCTION:Historically, metastatic renal cell carcinoma (RCC) has had poor prognosis; the outcomes have improved with the introduction of tyrosine-kinase inhibitors, such as sunitinib. There is no reported literature from India on the use of sunitinib in metastatic RCC. We present an analysis of sunitinib at our ins...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118725
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulf...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_349_17
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Globally tobacco epidemic kills nearly six million people annually. Consumption of tobacco products is on the rise in low- and middle-income countries. Tobacco is addictive; hence, tobacco users need support in quitting. AIMS:Providing tobacco cessation services to women in community enabling them to quit t...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.147474
更新日期：2014-12-01 00:00:00
abstract：:Scrambler therapy (ST) is a novel noninvasive modality for treatment of chronic neuropathic and cancer pain using 5 artificial neurons. The principle with Scrambler Therapy is that synthetic "non-pain" information is transmitted by C fiber surface receptors. Chemotherapy-induced peripheral neuropathy can markedly dete...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_361_18
更新日期：2020-01-01 00:00:00
abstract：:A study of knowledge, attitude and practice with regard to tobacco usage was conducted in 1278 boys and 353 girls studying in the final year in various schools in Bombay. The proportion of boys given to one or the other form of tobacco usage (including experimenters/triers) was significantly higher in private English ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Infections are the most important cause of mortality in patients with high-risk febrile neutropenia. Emergence of multi-drug resistant organisms (MDROs) has become a major challenge for hemato-oncologists. Knowledge of the prevalent organisms and their antimicrobial sensitivity can help deciding the empirica...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175387
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:A relatively new development in the arena of prostatic histopathological study is the premalignant proliferative changes in the glandular epithelium, possibly relating to carcinoma. Two major categories have come up, namely prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (AAH)....
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:Twenty-two histologically confirmed cases of Clear Cell Sarcomas (C.C.S.) seen over a sixteen year period, are retrospectively analysed from a clinico-pathological view-point. The tumours occurred in young adults, average 36 years. Males predominated, and the lower extremity particularly the thigh and foot were the mo...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:Cancer is a manifestation of dysregulated gene function arising from a complex interplay of oncogenes and tumor suppressor genes present in our body. Cancer has been constantly chased using various therapies but all in vain as most of them are highly effective only in the early stages of cancer. Recently, RNA interfer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175598
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:The aim was to evaluate the safety, feasibility and efficacy of computed tomography (CT)-guided percutaneous interstitial brachytherapy using radioactive iodine-125 ( 125 I) seeds for the treatment of lung cancer. MATERIALS AND METHODS:Included in this study were 45 male and 35 female patients aged 52-85 years...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.151999
更新日期：2015-02-01 00:00:00
abstract：AIMS AND BACKGROUND:The immunoprofile of the Reed Sternberg cell with respect to immunoreactivity for CD20 and lack of CD15 has been described as a poor prognostic factor. Large scale studies analyzing the immunoprofile of Hodgkin's lymphoma (HL) from India are lacking. The aim of this study was to obtain baseline info...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.41772
更新日期：2008-04-01 00:00:00
abstract：:Five cases of primary lymphoma of the brain are reported and the literature reviewed. The diverse clinical spectrum at presentation and variable response to therapy are few of its unique features. The literature is reviewed briefly and the importance of diagnosis at an early stage and prompt institution of therapy in ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175332
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES:The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_155_17
更新日期：2017-01-01 00:00:00
abstract：:Background: The aim of this study was to investigate the association of head and neck squamous cell carcinoma (HNSCC) with serum levels of interleukin-7 (IL-7) and IL-8, the two cytokines whose associations with HNSCC need more clarifications. Materials and Methods: Commercial enzyme-linked immunosorbent assay kits we...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146728
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:The aim of this prospective study was to evaluate the effects of radiotherapy (RT) on psychiatric disorder in patients undergoing RT for head and neck cancer. MATERIALS AND METHODS:The prospective study included 51 patients with head and neck cancer. The diagnosis of psychiatric disorder was made by Diagnostic...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.180816
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This st...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_737_18
更新日期：2019-10-01 00:00:00
abstract：:A rare morphological variant of acute lymphoblastic leukaemia in a ten years old child is described. Ninety five percent of the lymphoblasts had significant number of course granules in the cytoplasm. Diagnostic and prognostic significance of this variant is discussed. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases includi...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.107735
更新日期：2012-10-01 00:00:00
abstract：Background:Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods:Seventy patients diagn...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_459_19
更新日期：2020-12-10 00:00:00
abstract：:The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaem...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_260_18
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.65316
更新日期：2010-07-01 00:00:00
abstract：:We present an interesting case of port site metastasis is a menopausal women subsequent to diagnostic laparoscopy undertaken for chronic pelvic pain, which later proved early ovarian malignancy as the source of primary. While cases of port site metastasis have mostly occurred after extensive disease the possbility of ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:Primary undifferentiated embryonal of the liver in children is a rare neoplasm with dismal prognosis. Surgery is the treatment of choice. Adjuvant chemotherapy may prove useful in improving the prognosis of these tumours. We report two cases of Primary undifferentiated embryonal sarcoma of the liver. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma (MM) characterized by a fulminant course and poor prognosis. Flow cytometry (FCM) is very useful in the diagnosis of the plasma cell leukemia. Herein, we present 10 cases of PCL. MATERIALS AND METHODS:We retrospectively studied immu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134605
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The utilization and extent of pelvic lymph node dissection (PLND) varies depending on the disease and practice patterns. AIMS:This study compares practice patterns in utilization of PLND between Indian and United States (US) practices. SETTINGS AND DESIGN:We focused on 415 patients (204 India; 211 US) pros...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_227_17
更新日期：2017-04-01 00:00:00
abstract：:Meticulous staging of ovarian cancer has so far been a prerequisite for treatment planning. However, more than 80% of patients operated by non-oncologists all over the world do not under go a complete staging. Recently there have been reports questioning the need for extensive staging from the point of cervical benefi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
