Abstract：
:Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mutation on disease progression. Analysis of tumor tissue biopsy material is considered as gold standard for mutation detection. However, lung re-biopsy in a progressed patient involves several challenges - access to tumor, patient's willingness, safety, cost. Minimally invasive plasma circulating tumor DNA (ctDNA) evolved as an alternative for detection of EGFR T790M mutation when tumor genotyping is not feasible. Although a positive T790M result from ctDNA analysis is actionable, caution should be exercised in interpreting negative plasma results. A negative result may imply the absence of a mutation or merely that a patient's tumor is not shedding ctDNA at detectable levels, thus necessitating a confirmatory tissue biopsy to rule out a false negative plasma result. In this case report, we described a 78-year-old female who underwent a reflexed tumor biopsy and tissue based testing upon negative plasma genotyping. Our case report exhibited the importance to follow proposed T790M plasma testing algorithm to screen eligible patients for 3rd generation TKI therapy.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Mistry R,Patil Adoi
10.4103/ijc.IJC_545_17subject
Has Abstractpub_date
2017-12-01 00:00:00pages
S65-S66issue
Supplementeissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2017_54_5_65_221926journal_volume
54pub_type
abstract：:We have studied fibrinolytic activity of 12 cases of infiltrating duct carcinoma of breast (7 metastatic and 5 non-metastatic) and ten cases of adenocarcinoma of gastrointestinal tract (5 each of metastatic and nonmetastatic), and compared with some of their normal tissue counterparts. Both metastatic and non-metastat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:The prognostic relevance of histologic differentiation in gastric carcinoma patients with curative resection is unclear. We analyzed the clinicopathologic features of gastric carcinoma patients with curative resection according to the histologic differentiation and evaluated surgical outcome. MATERIALS AND ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175569
更新日期：2015-01-01 00:00:00
abstract：:Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.65316
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Lymphedema following breast cancer treatment is one of the most morbid conditions affecting breast cancer survivors. Currently, no therapy completely cures this condition. Comprehensive Decongestive Therapy (CDT), a novel physiotherapeutic method offers promising results in managing this condition. This ther...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.92250
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197726
更新日期：2016-04-01 00:00:00
abstract：:It is important to differentiate non-dyplastic aplastic anaemia from hypocellular myelodysplastic syndrome (MDS). Four patients presenting with hypocellular bone marrow and different evolution patterns are being described. Certain morphological features and variable hypocellularity were found to be useful indices for ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：INTRODUCTION:In our study, we have treated cases of early glottic carcinoma by two different dose-fractionation schedules in relation to overall treatment time. MATERIALS AND METHODS:This is an analysis of 29 patients with invasive, previously untreated T1and T2squamous cell carcinoma of true vocal cord that was treat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200677
更新日期：2016-07-01 00:00:00
abstract：:Gliomatosis cerebri is a vary rare neoplastic lesion of the central nervous system. An intra-vitam diagnosis of gliomatosis cerebri can be suggested with a steleolactic biopsy of the lesion in conjunction with Magnetic Resonance Imaging (MRI) findings in the brain. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：CONTEXT:Cancer profile varies in different regions and depends on race, lifestyle and diet. The study of a cancer profile helps to know the common cancers in a particular population, its probable risk factors and also helps in cancer control programs. AIM:To study the cancer profile at Kolar, based on Pathology Depart...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.63011
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118732
更新日期：2013-07-01 00:00:00
abstract：CONTEXT AND AIM:The prognosis of primary gliosarcoma (PGS) remains dismal with current treatment modalities. We analyzed the outcome of PGS patients treated with concurrent and adjuvant temozolomide (TMZ). SETTINGS AND DESIGN:Retrospective single institutional analysis. MATERIALS AND METHODS:We retrospectively evalua...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.178407
更新日期：2015-10-01 00:00:00
abstract：CONTEXT:Malnutrition is prevalent in children with cancer at diagnosis, especially in low- and middle-income countries (LMIC) where the great majority of children live. It is associated with an added burden of morbidity and mortality. AIMS:Answers were sought to the best measure of nutritional status in LMIC, the impa...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175827
更新日期：2015-04-01 00:00:00
abstract：:Cervical cancer is the leading malignancy among Indian women. It has been estimated that in the absence of any control programme, the incident number of cervical cancer cases in the country would rise to 140 thousand by the turn of this century. Cytology screening remains the main stay for the control of cervix cancer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：:The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent of all salivary gland tumors. Central mucoepidermoid carcinoma of the jaws is rare. Following is a case report of central mucoepidermoid carcinoma which involves the ramus of the mandible. Origin of the central mucoepidermoid carcinoma is discuss...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The utilization and extent of pelvic lymph node dissection (PLND) varies depending on the disease and practice patterns. AIMS:This study compares practice patterns in utilization of PLND between Indian and United States (US) practices. SETTINGS AND DESIGN:We focused on 415 patients (204 India; 211 US) pros...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_227_17
更新日期：2017-04-01 00:00:00
abstract：:Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175805
更新日期：2015-04-01 00:00:00
abstract：Background:Despite the advances in screening during the past decades, colorectal cancer (CRC) still is a leading cause of cancer deaths worldwide. Therefore, the development of new diagnostic methods is necessary. Aim:The aim of this study was to compare methylation changes of SRY-Box 21 (SOX21) gene promoter in tumor...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_542_18
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.104499
更新日期：2012-07-01 00:00:00
abstract：:A case of low grade hemangiopericytoma of three years duration occurring in the upper end of the femur of a 70 year old man is described. Radiologically, the upper third of the right femur showed a destructive expansile osteolytic lesion with soft tissue extension. The tumour was partially encapsulated. Mitoses were 0...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series fro...
journal_title：Indian journal of cancer
pub_type：
doi：10.4103/ijc.IJC_499_17
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. AIM:To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197725
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES:The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of th...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_155_17
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Recent studies indicate neoadjuvant chemotherapy (NACT) can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF) NACT in our setting is lacking. The pr...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.134649
更新日期：2014-01-01 00:00:00
abstract：:Alpha-fetoprotein secreting (AFP) Sertoli-Leydig cell tumors of ovary (SLCT) are now identified as a distinct entity among the uncommon group of sex cord tumors of ovary. We report an unusual case of recurrent AFP secreting ovarian tumors and as ileocecal mesenteric cyst in a 25-year-old patient resulting in difficult...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.48599
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.35810
更新日期：2007-04-01 00:00:00
abstract：INTRODUCTION:: Indian families are known for adopting the role of caregiver naturally when someone in the family falls ill to cancer. Although there were strong family structure and system existed here, now the changing family pattern and structure are challenging the role of cancer caregiving as well. OBJECTIVE:: Thi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_211_17
更新日期：2017-04-01 00:00:00
abstract：: ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_551_18
更新日期：2018-10-01 00:00:00
abstract：:Background: The aim of this study was to investigate the association of head and neck squamous cell carcinoma (HNSCC) with serum levels of interleukin-7 (IL-7) and IL-8, the two cytokines whose associations with HNSCC need more clarifications. Materials and Methods: Commercial enzyme-linked immunosorbent assay kits we...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146728
更新日期：2014-07-01 00:00:00
