Immunohistochemical detection of axillary lymph node micrometastases in breast cancer patients: Increasing the accuracy of detection and decreasing labor intensive serial sectioning.


:Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investigated whether immunohistochemical techniques and serial sectioning can increase the accuracy of metastatic detection and compared the efficacy of both. Materials and Methods: Thirty cases of breast carcinoma were studied in all of whom the axillary lymph nodes had been reported as free of metastases. Blocks from these cases were serially sectioned and stained with hematoxylin and eosin and a single section was stained with monoclonal antibody to cytokeratin AE1/AE3 and epithelial membrane antigen. The positivity for micrometastases was correlated with size, number, grade and histological type of primary tumor, lymph node size and number. Results and Conclusion: In 5/30 previously unsuspected cases, micrometastases were revealed by IHC and in 1/30 by serial sectioning. These findings suggested that serial sectioning is a labor intensive, time consuming and impractical procedure. Micrometastases were more frequently detected with age of patient >50 years, Grade 2/3 tumor, tumor size >5 cm and more than one primary tumor. Immunohistochemical analysis can be recommended as a routine procedure or an adjunct to routine histological procedures for the correct staging of breast carcinoma and use of adjuvant chemotherapy, especially in the high risk group.


Indian J Cancer


Indian journal of cancer


Yadav R,Singh S,Marwah N,Kataria K,Aggarwal G,Sen R




Has Abstract


2014-07-01 00:00:00














  • The founding of the Tata Memorial Hospital, 1932-1941.

    abstract::This article presents a brief account of the founding of the Tata Memorial Hospital. It draws upon archival material to show that this was not a mere philanthropic act but a scheme carefully thought-out by the Trustees of the Sir Dorabji Tata Trust. It discusses the major concerns of the Trustees as they deliberated u...

    journal_title:Indian journal of cancer

    pub_type: 历史文章,杂志文章


    authors: Kavadi SN

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  • Primary gastrointestinal non Hodgkin's lymphoma chemotherapy alone an effective treatment modality: experience from a single centre in India.

    abstract:BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...

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    authors: Raina V,Sharma A,Vora A,Shukla NK,Deo SV,Dawar R

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  • Delay in presentation to the hospital and factors affecting it in breast cancer patients attending tertiary care center in Central India.

    abstract:INTRODUCTION:Despite lower incidence of breast cancer in India, the total number of cases and the net mortality is high. To reduce this increasing load of mortality due to breast cancer we need to lay emphasis on early detection and increased use of systemic therapy. Early detection itself depends on early presentation...

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    authors: Thakur NA,Humne AY,Godale LB

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    journal_title:Indian journal of cancer

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    authors: Sanjay BK

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  • Treatment in resectable non-metastatic adenocarcinoma of stomach: Changing paradigms.

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    authors: Chelakkot PG,Ravind R,Sruthi K,Menon D

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    abstract:BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...

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    authors: Chintha R,Kaipa PR,Sekhar N,Hasan Q

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  • Tamoxifen use and gallstone formation in postmenopausal breast cancer patients in south Indian population.

    abstract:BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...

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    authors: Mohamed A,Kadambari D,Bhuvaneswari V

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  • Rehabilitation of a mandibular segmental defect with magnet retained maxillofacial prosthesis.

    abstract::Resection or loss of a portion of the mandible can result in a variety of functional, cosmetic and psychological deficits that are dependent on the extent of the defect, the concomitant therapy and the timing of rehabilitative efforts. These impairments greatly affect the patient's Quality of life (QOL). The thrust in...

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    abstract:Background:Low- and middle-income countries require to specify early detection programs and intervention models for breast cancer. The aim of this study was to assess the performance efficacy of an Iraqi early detection model in terms of cancer detection rate (CDR) and the method of participation in this program. Mate...

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    authors: Abdollah F,Arora S,Jindal T,Gild P,Sood A,Yuvaraja TB,Ahlawat RK,Gupta NP,Bhandari M,Menon M

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    authors: Dhawan IK,Verma K,Khazanchi RK,Madan NC,Shukla NK,Saxena R

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  • Risk predictors for adverse outcome in pediatric febrile neutropenia: Single center experience from a low and middle-income country.

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    authors: Prasad M,Chinnaswamy G,Arora B,Vora T,Hawaldar R,Banavali S

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    authors: Kumar R,Bozkurt MF,Zhuang H,Alavi A

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    journal_title:Indian journal of cancer

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    authors: Dong-Xu W,Jia L,Su-Juan Z

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    abstract::Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Thre...

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    journal_title:Indian journal of cancer



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    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Doval DC,Naresh KN,Sabitha KS,Vijaykumar M,Bapsy PP,Anantha N,Kumarswamy SV

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    pub_type: 杂志文章


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