Abstract：
BACKGROUND:Metaplastic breast carcinoma (MBC) is a rare disease with incidence of less than 1%. MBC present with a larger tumor size, less number of nodes involved, mostly undifferentiated triple negative tumors. We aimed to determine progression-free and overall survival and reported hospital-based incidence of MBC. MATERIAL AND METHODS:A retrospective closed Cohort study elicited data of 42 patients with MBC from January 2008 to December 2013; followed till August 2016. Kaplan-Meier method was applied to compute overall and progression-free survival analysis. Cox Proportional hazard ratios were computed to assess associations between survival and independent variables. RESULTS:Hospital-based incidence of MBC was 1.92% (42/2187), 95% CI [1.41-2.56]. The median age at tumor diagnosis was 54 years (range, 25-81 years). Thirty-nine (92.9%) patients had Grade III tumor. The most common histopathology was squamous (69%). The median tumor size was 4.5 cm (range, 0.8-17 cm). Nineteen (45.2%) patients had nodal involvement at diagnosis. Four patients (9.5%) had metastatic disease at presentation. Hormone receptors were positive in 19 (45.2%) patients. Her-2 neu receptor was positive in 9 (19%) patients. Sixteen (38.1%) patients had triple negative disease. Neoadjuvant and adjuvant chemotherapy was received by 10 (31.25%) and 19 (45.2%) patients respectively. Both median progression-free and overall survival was 38 months. CONCLUSION:Five-year progression-free and overall survival was 79.5% and 76.3%, respectively. We report better survival outcomes when compared to series described earlier despite our patient population presenting mostly with high grade, large tumors, and half of them exhibiting nodal and hormonal involvement.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Samoon Z,Beg M,Idress R,Jabbar AAdoi
10.4103/ijc.IJC_731_18subject
Has Abstractpub_date
2019-04-01 00:00:00pages
124-129issue
2eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2019_56_2_124_257565journal_volume
56pub_type
杂志文章abstract：BACKGROUND:The utilization and extent of pelvic lymph node dissection (PLND) varies depending on the disease and practice patterns. AIMS:This study compares practice patterns in utilization of PLND between Indian and United States (US) practices. SETTINGS AND DESIGN:We focused on 415 patients (204 India; 211 US) pros...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_227_17
更新日期：2017-04-01 00:00:00
abstract：:Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Thre...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:Three cases of damage to the optic nerves and chiasma following pituitary irradiation with Co60 teletherapy are described. All of them presented with progressive visual impairment months following irradiation and simulated recurrence of the tumour. CT scan was also not helpful in differentiating radionecrosis from tum...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：INTRODUCTION:In our study, we have treated cases of early glottic carcinoma by two different dose-fractionation schedules in relation to overall treatment time. MATERIALS AND METHODS:This is an analysis of 29 patients with invasive, previously untreated T1and T2squamous cell carcinoma of true vocal cord that was treat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200677
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.123611
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:: Indian families are known for adopting the role of caregiver naturally when someone in the family falls ill to cancer. Although there were strong family structure and system existed here, now the changing family pattern and structure are challenging the role of cancer caregiving as well. OBJECTIVE:: Thi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_211_17
更新日期：2017-04-01 00:00:00
abstract：:Serum levels of Lactate Dehydrogenase (LDH), alpha-Hydroxybutyrate Dehydrogenase (HBDH) and the relative ratio of alpha-Hydroxybutyrate Dehydrogenase to Lactate Dehydrogenase (HBDH/LDH) were determined in 51 cases of histologically proved testicular germ cell tumors and 40 healthy controls. Serum LDH and HBDH levels w...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:During the last 11 years, 101 patients of Wilms tumor were seen. Of these, 13 patients had metastatic disease at onset while 24 patients presented with relapse at a latter date. Seven patients have been cured, all had favourable histology. The risk factors associated with relapse were found to be unfavourable histolog...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：CONTEXT AND AIM:The prognosis of primary gliosarcoma (PGS) remains dismal with current treatment modalities. We analyzed the outcome of PGS patients treated with concurrent and adjuvant temozolomide (TMZ). SETTINGS AND DESIGN:Retrospective single institutional analysis. MATERIALS AND METHODS:We retrospectively evalua...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.178407
更新日期：2015-10-01 00:00:00
abstract：: ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_551_18
更新日期：2018-10-01 00:00:00
abstract：:Spindle cell haemangioendothelioma (SCH) is a low grade, slowly progressive angiosarcoma of multifocal nature with local recurrences being common. It is histologically marked by cavernous blood spaces and a spindle cell stroma. Its importance lies in recognising its relatively benign nature and differentiating it from...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.117023
更新日期：2013-04-01 00:00:00
abstract：:Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage II...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Lymphoma combined with hepatitis B infection occupies a relatively higher incidence in China than that of in Europe and America. AIMS:To observe the efficacy and safety of rituximab in combination with chemotherapy in patients with B-cell non-Hodgkin's lymphoma (NHL) and hepatitis B virus (HBV) infection. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200679
更新日期：2016-07-01 00:00:00
abstract：:In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases includi...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.107735
更新日期：2012-10-01 00:00:00
abstract：:Uncommon patterns of presentation of acute leukemia pose diagnostic problems. A rheumatological prodrome in acute myeloblastic leukemia is very rare. We describe one such patient who had a normal haemogram. Bone marrow examination done later revealed acute myeloblastic leukemia. The case is discussed with reference to...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.197726
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175321
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.4103/ijc.IJC_174_17
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that affects multiple tissues derived from the neural crest. Inheritance of MTC is related to the presence of specific mutations in the RET proto-oncogene. Almost all mutations in MEN 2A involve one of the cystei...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509x.27934
更新日期：2006-07-01 00:00:00
abstract：:A seventy year old man presented with bone pains. Investigation revealed a metastatic bone lesion in the humerus. The primary was found in the liver. The patient achieved good palliation with chemotherapy and radiotherapy and survived for one year. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:A rare case of pleomorphic intimal sarcoma of pulmonary trunk is reported. The patient presented with symptoms of right ventricular out flow tract (RVOT) obstruction. Metastatic deposits were seen in lungs, diaphragm and thyroid. Bronchial mucosal involvement was also seen. The tumour showed multicentric origin and on...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：OBJECTIVES:We aimed to study the compliance and treatment outcome of patients who received adjuvant treatment following curative resection for periampullary cancers periampullary cancers. MATERIALS AND METHODS:Institute medical records of PAC treated during 2007-2014 were retrieved. Demographics, treatment, and outcom...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_358_17
更新日期：2017-07-01 00:00:00
abstract：Background and Objectives:Salivary gland neoplasms are relatively uncommon. They have a wide variety of histopathological types with diverse biological behavior. It involves all the major and minor salivary glands in the head and neck. This article focuses on the various types of major salivary gland tumors treated at ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_466_17
更新日期：2018-01-01 00:00:00
abstract：:Ten patients of the advanced malignant germ cell tumours of the ovary were treated by cisplatin based combination chemotherapy after initial conservation surgery. Eight patients completed course containing cisplatinum, vinblastine and bleomycin. Five patients (62.5%) achieved CR while 2 (25%) attained PR. One patient ...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:A case report of a squamous cell carcinoma arising in a dermoid cyst of the ovary in a 29 year old patient is presented. Such an occurrence in young patients is unusual. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:The deregulation of microRNA-185 (miR-185) has been showed to be associated with many cancers and act as a tumor suppressor in many types of human malignancies. We hence tried to find out its role in human colorectal cancer (CRC). MATERIALS AND METHODS:miR-185 expression was investigated by real-time quantit...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.186576
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.84932
更新日期：2011-07-01 00:00:00
abstract：Background:Gestational trophoblastic neoplasia (GTN) are a spectrum of tumors that develop from placental tissue. We aimed to evaluate the management and treatment outcome of GTN. Methods:Patients diagnosed with GTN presented to Kasr Alainy Center of Clinical Oncology between 2008 and 2017 were included in this study....
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_551_19
更新日期：2021-01-06 00:00:00
