Abstract:
BACKGROUND:Wilms' tumor 1 (WT1) mutation has recently been detected in gliomas. Growing data indicate that WT1 mutation plays a causal role in gliomagenesis and is overexpressed in most glioblastomas. An emerging immunotherapy targeting WT1 has shown to be effective in resistant glioblastomas in clinical trials. WT1 expression and its potential utility in various grades of astrocytomas is still unclear and needs further elucidation. The evaluation of WT1 can be done by molecular or immunohistochemical methods. As immunohistochemistry is easier with wider routine use, immunoexpression of this biomarker was studied. AIM:The aim of this study was to characterize WT1 immunoexpression across different histological grades of astrocytomas to routinely aid in diagnosis and reproducibility and to assess the association between WT1 and immunomarker isocitrate dehydrogenase (IDH1). MATERIAL AND METHODS:This was an observational prospective study on 79 cases of astrocytomas. RESULTS:Seventy-nine astrocytomas including 11 recurrent tumors were assessed for WT1 by immunohistochemistry. WT1 expression was detected in all astrocytomas (100%). The control group of reactive gliosis was negative. WT1 score correlated with histological tumor grades (P < 0.001) with higher score in higher grade. It was also observed that different tumor grades depicted two distinct expression patterns. WT1 score and pattern were valuable in differentiating high- and low-grade astrocytomas. CONCLUSION:This study supports the oncogenic role of WT1 in astrocytomas. WT1 was found to be valuable in distinguishing different grades of astrocytomas. WT1 can aid in differentiating neoplastic process from reactive gliosis, particularly in recurrent tumors. Higher expression in glioblastomas supports its immunotherapy potential.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Manocha A,Jain Sdoi
10.4103/ijc.IJC_51_18subject
Has Abstractpub_date
2019-07-01 00:00:00pages
197-201issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2019_56_3_197_263036journal_volume
56pub_type
杂志文章abstract::Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.175805
更新日期:2015-04-01 00:00:00
abstract::Twenty-two histologically confirmed cases of Clear Cell Sarcomas (C.C.S.) seen over a sixteen year period, are retrospectively analysed from a clinico-pathological view-point. The tumours occurred in young adults, average 36 years. Males predominated, and the lower extremity particularly the thigh and foot were the mo...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:CONTEXT:Use of neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) enables tumor reduction and conservative surgery. It is proposed in some studies that there may be an alteration in the hormonal receptor (HR) status and human epidermal growth factor receptor 2 (Her-2)/neu immune-expression followi...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.200669
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:The deregulation of microRNA-185 (miR-185) has been showed to be associated with many cancers and act as a tumor suppressor in many types of human malignancies. We hence tried to find out its role in human colorectal cancer (CRC). MATERIALS AND METHODS:miR-185 expression was investigated by real-time quantit...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.186576
更新日期:2015-12-01 00:00:00
abstract::Gliomatosis peritonei (GP), a rare condition related to ovarian teratomas, is characterized by miliary implants of mature glial tissues on the peritoneum or omentum. We report herein a case of mature teratoma of the ovary with GP with imaging features and pathological correlation. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.17064
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.82901
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer. OBJECTIVES:The objective of this study was to find ou...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.64723
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:When microwave ablation (MWA) is used for subpleural lesions, severe pain was the common side effect under the local anesthesia conditions during the procedure and postprocedure. To study the pain relief effect of artificial pneumothorax in the treatment of subpleural lung tumors with MWA. MATERIALS AND MET...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.172519
更新日期:2015-12-01 00:00:00
abstract::Cytogenetic analysis using G-banding techniques for the diagnosis of malignancy in pleural and peritoneal effusions is compared with the results of traditional cytomorphology. The studies indicate that the yield of mitotic cells in malignant effusions is quite high when compared to fluids with no cytological evidence ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Positron emission tomography (PET) has emerged as an important diagnostic tool in the management of lung cancers. Although PET is sensitive in detection of lung cancer, but FDG (2-deoxy-2- 18 fluro-D-glucose) is not tumor specific and may accumulate in a variety of nonmalignant conditions occasionally giving false pos...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509x.44660
更新日期:2008-10-01 00:00:00
abstract::Neuroendocrine tumors, including carcinoids account for less than 1% of gastric tumors. Various subtypes of gastric carcinoids have been reported earlier. The present case deals with two unusual presentations, diagnosis and course of a gastric neuroendocrine tumor in an adult patient. A 35-years-old male initially pre...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.16700
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Seroma formation after mastectomy typically delays recovery and adds to morbidity. AIMS:This retrospective review was undertaken to identify factors which predict development of seroma after mastectomy for breast cancer patients. SETTING AND DESIGN:119 consecutive patients intended for mastectomy for the t...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.38940
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:We aimed to study the compliance and treatment outcome of patients who received adjuvant treatment following curative resection for periampullary cancers periampullary cancers. MATERIALS AND METHODS:Institute medical records of PAC treated during 2007-2014 were retrieved. Demographics, treatment, and outcom...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_358_17
更新日期:2017-07-01 00:00:00
abstract:Background:Neoadjuvant concurrent chemoradiation (CTRT) is not widely practiced in breast cancers. The current study presents our experience with the use of neoadjuvant CTRT in patients with locally advanced breast cancers (LABC) treated at our center. Methods:The study included all consecutive female patients with in...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_524_19
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.118732
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.15098
更新日期:2005-01-01 00:00:00
abstract::Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.146774
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical eff...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.204767
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The standard of care of patients with cancer of cardia and esophagus still remains surgery in early stage. One of the most feared complications after such procedure is anastomotic leak. AIM:We present our experience with omental wrapping of anastomosis (omentoplasty) to decrease the anastomotic leak. SETTI...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Twenty five patients of advanced breast cancer (Stage IIIb and IV) were studied and the histological changes following chemotherapy were looked. All the tumours showed varying degree of histological changes. Twenty eight percent tumours showed Grade I changes, 28 percent had Grade II changes and 28 percent had Grade I...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:INTRODUCTION:Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulf...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_349_17
更新日期:2017-07-01 00:00:00
abstract::Serum levels of Lactate Dehydrogenase (LDH), alpha-Hydroxybutyrate Dehydrogenase (HBDH) and the relative ratio of alpha-Hydroxybutyrate Dehydrogenase to Lactate Dehydrogenase (HBDH/LDH) were determined in 51 cases of histologically proved testicular germ cell tumors and 40 healthy controls. Serum LDH and HBDH levels w...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Six patients of primary lymphoma of breast are presented. All our patients were female with median age of 46 years. Combination chemotherapy was the mainstay of treatment in all the patients. Five patients achieved complete remission of which two relapsed, one had a distant relapse and the other was local. Patient wit...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
abstract::This report documents the occurrence of an extragonadal malignant teratoma on the sole of the foot, in a young male. The patient also developed a groin nodule showing the same histology. The testes, retroperitoneum and mediastinum, which are usual sites of germ cell tumours were all normal, and no other primary could ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:The Medical Oncology Department at Tata Memorial Hospital, the single largest tertiary cancer care center in Asia, receives in-house registered and referral patient samples from all parts of the country. Our recent studies establish 23% EGFR mutation frequency among Indian population. Here, we extend our stu...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.117023
更新日期:2013-04-01 00:00:00
abstract::The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaem...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage II...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:Background:Gestational trophoblastic neoplasia (GTN) are a spectrum of tumors that develop from placental tissue. We aimed to evaluate the management and treatment outcome of GTN. Methods:Patients diagnosed with GTN presented to Kasr Alainy Center of Clinical Oncology between 2008 and 2017 were included in this study....
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_551_19
更新日期:2021-01-06 00:00:00
abstract::Cervical cancer is the leading malignancy among Indian women. It has been estimated that in the absence of any control programme, the incident number of cervical cancer cases in the country would rise to 140 thousand by the turn of this century. Cytology screening remains the main stay for the control of cervix cancer...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-06-01 00:00:00
abstract::Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00