Methoxyphenyl maleamic acid augments the activity of cytotoxic drugs against murine tumours.

Abstract:

:The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaemia, whereas S180 (ascites) tumour was not responsive to the combined treatment. The possible mechanism (s) of action, responsible for the modulation of activity of CTX and HN2 against P388 tumour have been postulated.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Indap MA,Ambaye RY

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

22-6

issue

1

eissn

0019-509X

issn

1998-4774

journal_volume

28

pub_type

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