Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population.

Abstract:

BACKGROUND:The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer. OBJECTIVES:The objective of this study was to find out the association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. MATERIALS AND METHODS:In this study, 48 gastric cancer patients were diagnosed. Genomic DNA was extracted by a salting-out method. The MDR1 polymorphism was studied by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method, using a standard method. RESULTS:The polymorphic homozygote (T/T) genotype showed significantly an association with the incidence of gastric cancer compared with controls (P < 0.05). CONCLUSIONS:This study suggests that C3435T polymorphism of the MDR1 gene may be associated with gastric cancer in an ethnic Iranian population.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Sabahi Z,Salek R,Heravi RE,Mosaffa F,Avanaki ZJ,Behravan J

doi

10.4103/0019-509X.64723

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

317-21

issue

3

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2010_47_3_317_64723

journal_volume

47

pub_type

杂志文章
  • Undifferentiated embryonal sarcoma of the liver in childhood.

    abstract::Primary undifferentiated embryonal of the liver in children is a rare neoplasm with dismal prognosis. Surgery is the treatment of choice. Adjuvant chemotherapy may prove useful in improving the prognosis of these tumours. We report two cases of Primary undifferentiated embryonal sarcoma of the liver. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Mistry RC,Deshpande RK,Chinoy R,Sampat M,Desai PB

    更新日期:1995-12-01 00:00:00

  • Factors influencing the evaluation of an article in cancer literature.

    abstract::Casual Interpretation of results in a given article has several pitfalls. In order to assess the strengths and limitations of a given article several factors need to be considered. This review article is intended to list, classify and describe briefly the factors that should be considered in the evaluation of an artic...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Kumaraswamy,Supe SS,Ramesh C

    更新日期:1999-06-01 00:00:00

  • Primary lymphoma of the brain--a report of 5 cases and review of the literature.

    abstract::Five cases of primary lymphoma of the brain are reported and the literature reviewed. The diverse clinical spectrum at presentation and variable response to therapy are few of its unique features. The literature is reviewed briefly and the importance of diagnosis at an early stage and prompt institution of therapy in ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Sharma S,De S,Fernandes P,Singhal S,Singh K,Chander S,Rath GK

    更新日期:1991-06-01 00:00:00

  • Compliance to radiotherapy: A tertiary care center experience.

    abstract:CONTEXT:The most commonly prescribed conventional fractionation radiotherapy uses 1.8-2.2 Gy per fraction for five fractions in a week. Many times, unwanted interruptions are encountered, which ultimately affect the local control and overall survival. AIMS:The present retrospective study was carried out to study the c...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/ijc.IJC_517_17

    authors: Gupta S,Rastogi K,Bhatnagar AR,Singh D,Gupta K,Choudhary AS

    更新日期:2018-04-01 00:00:00

  • Metachronous multicentric giant-cell tumour: a case report.

    abstract::Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Sadat-Ali M

    更新日期:1997-12-01 00:00:00

  • FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry 'Equivocal' interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center expe

    abstract:Background:Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Methods:We explored the prevalence of ROS1, ALK, MET mutations, discu...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/ijc.IJC_470_19

    authors: Singh A,Kumar R,Shetty O,Desai S,Rane S

    更新日期:2020-11-24 00:00:00

  • MicroRNA-185 is a novel tumor suppressor by negatively modulating the Wnt/β-catenin pathway in human colorectal cancer.

    abstract:OBJECTIVE:The deregulation of microRNA-185 (miR-185) has been showed to be associated with many cancers and act as a tumor suppressor in many types of human malignancies. We hence tried to find out its role in human colorectal cancer (CRC). MATERIALS AND METHODS:miR-185 expression was investigated by real-time quantit...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.186576

    authors: Dong-Xu W,Jia L,Su-Juan Z

    更新日期:2015-12-01 00:00:00

  • Retrospective audit of clinico-pathologic features and treatment outcomes in a cohort of elderly non-Hodgkin's lymphoma patients in a tertiary cancer center.

    abstract:INTRODUCTION:There is limited data from India regarding elderly non-Hodgkin's lymphomas (NHL) patients. Hence, this audit was planned to study the clinic-pathological features and treatment outcomes in elderly NHL patients. METHODS:Retrospective analysis of all NHL patients above age of 59 years treated at the author'...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.178434

    authors: Nair CK,Patil VM,Raghavan V,Babu S,Nayanar S

    更新日期:2015-10-01 00:00:00

  • Postoperative chemoradiation in patients with localized gastric adenocarcinoma: single center experience.

    abstract:BACKGROUND:5-Fluorouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the r...

    journal_title:Indian journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.4103/0019-509X.75816

    authors: Yoney A,Bati Y,Isikli L,Unsal M

    更新日期:2011-01-01 00:00:00

  • Persistent inflammation on Pap smear: does it warrant evaluation?

    abstract:OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.82901

    authors: Bhutia K,Puri M,Gami N,Aggarwal K,Trivedi SS

    更新日期:2011-04-01 00:00:00

  • The efficacy of pemetrexed and bevacizumab intrapleural injection for malignant pleural mesothelioma-mediated malignant pleural effusion.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the efficacy and safety of pemetrexed chemotherapy combined with intrapleural injection of pemetrexed and bevacizumab in the treatment of malignant pleural mesothelioma (MPM)-mediated malignant pleural effusion, and analyze the objective response rate (ORR), the me...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.154058

    authors: Chen D,Li X,Zhao H,Fu Y,Yao F,Hu J,Du N

    更新日期:2014-03-01 00:00:00

  • Cystosarcoma phyllodes: Pathological enigma: A retrospective review of 162 cases.

    abstract:PURPOSE:Phyllodes tumor (PT) is a rare fibroepithelial neoplasm comprising <1% of all breast tumors. Clinical spectrum ranges from benign (B), borderline (BL), and locally recurrent to malignant (M) and metastatic type. The aim of our study was to analyze the clinicopathological factors, compare treatment options, and ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.176698

    authors: Narayanakar RP,Gangaiah DM,Althaf S,Dev K,Kurpad V,Gurawalia J

    更新日期:2015-07-01 00:00:00

  • Delay in presentation to the hospital and factors affecting it in breast cancer patients attending tertiary care center in Central India.

    abstract:INTRODUCTION:Despite lower incidence of breast cancer in India, the total number of cases and the net mortality is high. To reduce this increasing load of mortality due to breast cancer we need to lay emphasis on early detection and increased use of systemic therapy. Early detection itself depends on early presentation...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.175602

    authors: Thakur NA,Humne AY,Godale LB

    更新日期:2015-01-01 00:00:00

  • Serum lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase and ratio of alpha-hydroxybutyrate dehydrogenase to lactate dehydrogenase in testicular tumours.

    abstract::Serum levels of Lactate Dehydrogenase (LDH), alpha-Hydroxybutyrate Dehydrogenase (HBDH) and the relative ratio of alpha-Hydroxybutyrate Dehydrogenase to Lactate Dehydrogenase (HBDH/LDH) were determined in 51 cases of histologically proved testicular germ cell tumors and 40 healthy controls. Serum LDH and HBDH levels w...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Khanolkar MM,Sirsat AV,Deshmane VH,Kamat MR

    更新日期:1990-12-01 00:00:00

  • Design, architecture and application of nanorobotics in oncology.

    abstract::Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:10.4103/0019-509X.175805

    authors: Saxena S,Pramod BJ,Dayananda BC,Nagaraju K

    更新日期:2015-04-01 00:00:00

  • Ewing's sarcoma with central nervous system metastasis--report of two cases.

    abstract::Isolated central nervous metastasis is rare in patients with Ewing's sarcoma. Here we report two cases with CNS metastasis as the sole manifestation of relapse with a brief review of the literature. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Doval DC,Pavithran K,Acharya RS,Kannan V,Mukherjee G,Bapsy PP

    更新日期:1997-03-01 00:00:00

  • Early diagnosis of cervical cancers. Our experience at the Rural Cancer Registry, Barshi, India.

    abstract::In the cervical cancer cases registered at the Cancer Hospital at Barshi, India during 1988-90, 99 of the 105 cases were clinically staged (Total number of cases registered: 136). The annual number of cases were too few for a comparison of stage distribution between the registry years. However, comparison of the propo...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Jayant K,Rao RS,Nene BM,Dale PS

    更新日期:1994-06-01 00:00:00

  • Aplastic anaemia versus hypocellular myelodysplastic syndrome.

    abstract::It is important to differentiate non-dyplastic aplastic anaemia from hypocellular myelodysplastic syndrome (MDS). Four patients presenting with hypocellular bone marrow and different evolution patterns are being described. Certain morphological features and variable hypocellularity were found to be useful indices for ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Varma N,Varma S,Marwaha N,Garewal G

    更新日期:1995-09-01 00:00:00

  • A study on biochemical facet of anemia in cancers: A strong link between erythropoietin and tumor necrosis factor alpha in anemic cancer patients.

    abstract:BACKGROUND:The three direct factors that could lead cancer patients to anemia, apart from therapy are iron deficiency, inflammatory cytokines surge and decreased erythropoietin (Epo). Our aim was to quantify biochemical and hematologic markers serum Epo, ferritin (Fe) and tumor necrosis factor-alpha (TNF-α) along with ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.175579

    authors: Kalyani P,Jamil K

    更新日期:2015-01-01 00:00:00

  • Tamoxifen use and gallstone formation in postmenopausal breast cancer patients in south Indian population.

    abstract:BACKGROUND:Tamoxifen is being used in patients with estrogen receptor positive breast cancer as an adjuvant or palliative hormonal therapy. w0 estern studies have found a 30% incidence of gallstones in patients who are taking Tamoxifen and they have proved a significant association between the two. OBJECTIVES:The obje...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.49154

    authors: Mohamed A,Kadambari D,Bhuvaneswari V

    更新日期:2009-04-01 00:00:00

  • Complimentary role of FDG-PET imaging and skeletal scintigraphy in the evaluation of patients of prostate carcinoma.

    abstract::Prostate cancer is one of the most common malignancies of elderly males. Management depends on the accurate estimation of disease both at initial diagnosis and in its subsequent course. In the present study, we evaluated the diagnostic utility of positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) in p...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.73572

    authors: Tiwari BP,Jangra S,Nair N,Tongaonkar HB,Basu S

    更新日期:2010-10-01 00:00:00

  • Carcinoma of buccal mucosa: incidence of regional lymph node involvement.

    abstract::Histopathological findings in 57 surgical specimens of T3 and T4 buccal mucosa cancers are reviewed. The incidence of the well-differentiated tumours (including verrucous carcinoma) was 61%. A moderate degree of lymphocytic infiltration of the tumour was present in 37% of patients. Histologically proven cervical lymph...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Dhawan IK,Verma K,Khazanchi RK,Madan NC,Shukla NK,Saxena R

    更新日期:1993-12-01 00:00:00

  • Cancer profile in the Department of Pathology of Sri Devaraj Urs Medical College, Kolar: a ten years study.

    abstract:CONTEXT:Cancer profile varies in different regions and depends on race, lifestyle and diet. The study of a cancer profile helps to know the common cancers in a particular population, its probable risk factors and also helps in cancer control programs. AIM:To study the cancer profile at Kolar, based on Pathology Depart...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.63011

    authors: Kalyani R,Das S,Bindra Singh MS,Kumar H

    更新日期:2010-04-01 00:00:00

  • Plasma cell leukemia: a retrospective study of 10 cases.

    abstract:BACKGROUND:Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma (MM) characterized by a fulminant course and poor prognosis. Flow cytometry (FCM) is very useful in the diagnosis of the plasma cell leukemia. Herein, we present 10 cases of PCL. MATERIALS AND METHODS:We retrospectively studied immu...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.134605

    authors: Agarwal AD,Brahmbhatt BS,Parikh BP,Shah MJ

    更新日期:2014-01-01 00:00:00

  • Proteomics analysis of human brain glial cell proteome by 2D gel.

    abstract:INTRODUCTION:Proteomics is increasingly employed in both neurological and oncological research, and applied widely in every area of neuroscience research including brain cancer. Astrocytomas are the most common glioma and can occur in most parts of the brain and occasionally in the spinal cord. Patients with high-grade...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.138271

    authors: Pooladi M,Abad SK,Hashemi M

    更新日期:2014-04-01 00:00:00

  • Composite carcinoid carcinoma of the colon--a case report.

    abstract::A composite tumour of the caecum and colon, comprising of distinct areas of classical carcinoid and of well differentiated adenocarcinoma is described. Both components were histochemically confirmed. Presence of a morphologic transition at junctional areas favour a histogenesis from bi-directional differentiation of m...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Chaturvedi KU,Kaur H

    更新日期:1994-09-01 00:00:00

  • Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18-45 years: A case-control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history.

    abstract:BACKGROUND:Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. AIM:To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of th...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.197725

    authors: Dholam KP,Chouksey GC

    更新日期:2016-04-01 00:00:00

  • Higher incidence of syndrome of inappropriate antidiuretic hormone secretion during induction chemotherapy of acute lymphoblastic leukemia in indian children.

    abstract:BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This st...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/ijc.IJC_737_18

    authors: Seetharam S,Thankamony P,Gopakumar KG,Krishna KMJ

    更新日期:2019-10-01 00:00:00

  • Juvenile nasopharyngeal angiofibroma: a single institution study.

    abstract:BACKGROUND:Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. AIMS:To present the experience of management of JNA at a single institution. SETTING AND DESIGN:This is a retrospective observational study of patients with JNA who prese...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.15098

    authors: Mistry RC,Qureshi SS,Gupta S,Gupta S

    更新日期:2005-01-01 00:00:00

  • Secondhand smoke in public places: can Bangalore metropolitan transport corporation be a role model for effective implementation of Cigarette and Other Tobacco Products Act, 2003?

    abstract:BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.65316

    authors: Nayak NS,Annigeri VB,Revankar DR,Kenchaigol S

    更新日期:2010-07-01 00:00:00