Abstract：
BACKGROUND:5-Fluorouracil (FU)-based chemotherapy (CT) and concurrent 45 Gy radiotherapy (RT) is one of the standard postoperative approaches currently used in gastric carcinoma. The high toxicity rates of this treatment leads to interruption of treatment in the majority of patients. In our study, we investigated the rates of toxicity and treatment discontinuation observed during postoperative FU-based chemoradiotherapy (CRT); retrospectively evaluated the effect of CRT and the other prognostic factors on local and distant control and survival. PATIENTS AND METHODS:A total of 160 patients consisting of 97 total and 63 subtotal gastrectomy receiving postoperative CRT, have been studied retrospectively. RESULTS:Patients who had to discontinue the treatment for a median of 6 (range, 3-13) days experienced toxicity during treatment at a rate of 43%. During the 21 (range, 4-68) months of follow-up local recurrences were observed in 8 (5%) patients and distant recurrences were observed in 41 (25.6%) patients. While the 1-3 year overall survival (OS) rates were 75% and 42%, 13-year disease-free survival (DFS) rates were 63% and 42%, respectively. In the univariate analysis for OS and DFS demonstrated statistical significance for below those 60 years of age, D1-D2 dissection type, negative surgical margin, early treatment beginning, the absence of invasion, and early stage disease. D1D2 dissection type, early treatment beginning, age below 60 years and early stage disease significantly improve OS and DFS in multivariate analysis. CONCLUSIONS:Survival is worse in patients older than 60 years, had late treatment beginning, advanced stage and D0 dissection.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Yoney A,Bati Y,Isikli L,Unsal Mdoi
10.4103/0019-509X.75816subject
Has Abstractpub_date
2011-01-01 00:00:00pages
24-30issue
1eissn
0019-509Xissn
1998-4774pii
75816journal_volume
48pub_type
临床试验,杂志文章abstract：:The procedure of facial resurfacing dictates that there should be an excellent colour and texture match between the facial and the transposed skin. Cervical flaps e.g. platysma flap are commonly used for reconstruction of facial defects but, with disadvantages like limited mobility, unacceptable donor site and unpredi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：PURPOSE:Phyllodes tumor (PT) is a rare fibroepithelial neoplasm comprising <1% of all breast tumors. Clinical spectrum ranges from benign (B), borderline (BL), and locally recurrent to malignant (M) and metastatic type. The aim of our study was to analyze the clinicopathological factors, compare treatment options, and ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176698
更新日期：2015-07-01 00:00:00
abstract：:In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the ce...
journal_title：Indian journal of cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：INTRODUCTION:In our study, we have treated cases of early glottic carcinoma by two different dose-fractionation schedules in relation to overall treatment time. MATERIALS AND METHODS:This is an analysis of 29 patients with invasive, previously untreated T1and T2squamous cell carcinoma of true vocal cord that was treat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200677
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175332
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:This study was undertaken to evaluate the clinicopathological characteristics of patients with breast cancer at our institute, a tertiary-care cancer center in northern India. MATERIALS AND METHODS:This retrospective study included all patients with breast cancer registered at our institute from January 1...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_73_18
更新日期：2018-07-01 00:00:00
abstract：:Radiotherapy forms one of the major treatment modalities for head and neck cancers (HNC), and precision radiotherapy techniques, such as intensity-modulated radiotherapy require accurate target delineation to ensure success of the treatment. Conventionally used imaging modalities, such as X-ray computed tomography (CT...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.64717
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175321
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The three direct factors that could lead cancer patients to anemia, apart from therapy are iron deficiency, inflammatory cytokines surge and decreased erythropoietin (Epo). Our aim was to quantify biochemical and hematologic markers serum Epo, ferritin (Fe) and tumor necrosis factor-alpha (TNF-α) along with ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175579
更新日期：2015-01-01 00:00:00
abstract：:The mucoepidermoid carcinoma (MEC) account for approximately 6-8 Percent of all salivary gland tumors. Central mucoepidermoid carcinoma of the jaws is rare. Following is a case report of central mucoepidermoid carcinoma which involves the ramus of the mandible. Origin of the central mucoepidermoid carcinoma is discuss...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Lymphedema following breast cancer treatment is one of the most morbid conditions affecting breast cancer survivors. Currently, no therapy completely cures this condition. Comprehensive Decongestive Therapy (CDT), a novel physiotherapeutic method offers promising results in managing this condition. This ther...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.92250
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:Sri Lanka became a signatory to the WHO Frame Work Convention on Tobacco Control in September 2003, and this was ratified in November 2003. With a view to reduce the use of tobacco in Sri Lanka, the National Authority on Tobacco and Alcohol Act (NATA) No. 27 of 2006 was implemented. AIM:To assess the beha...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.107753
更新日期：2012-10-01 00:00:00
abstract：:In the cervical cancer cases registered at the Cancer Hospital at Barshi, India during 1988-90, 99 of the 105 cases were clinically staged (Total number of cases registered: 136). The annual number of cases were too few for a comparison of stage distribution between the registry years. However, comparison of the propo...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Infections are the most important cause of mortality in patients with high-risk febrile neutropenia. Emergence of multi-drug resistant organisms (MDROs) has become a major challenge for hemato-oncologists. Knowledge of the prevalent organisms and their antimicrobial sensitivity can help deciding the empirica...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.175387
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer. OBJECTIVES:The objective of this study was to find ou...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.64723
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatin...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.176715
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Wilms' tumor 1 (WT1) mutation has recently been detected in gliomas. Growing data indicate that WT1 mutation plays a causal role in gliomagenesis and is overexpressed in most glioblastomas. An emerging immunotherapy targeting WT1 has shown to be effective in resistant glioblastomas in clinical trials. WT1 ex...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/ijc.IJC_51_18
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Esophageal cancer (EC) is one of the most frequent and serious cancers worldwide, but its geographic distribution is disparate. Northern Iran is known as one of the hot spots for EC, but there is inadequate evidence available regarding its characteristics in northwestern region of Iran. Therefore, this study...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.82875
更新日期：2011-04-01 00:00:00
abstract：:Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.178403
更新日期：2015-10-01 00:00:00
abstract：:Twenty-two histologically confirmed cases of Clear Cell Sarcomas (C.C.S.) seen over a sixteen year period, are retrospectively analysed from a clinico-pathological view-point. The tumours occurred in young adults, average 36 years. Males predominated, and the lower extremity particularly the thigh and foot were the mo...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.118732
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.123611
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.104499
更新日期：2012-07-01 00:00:00
abstract：CONTEXT:Use of neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) enables tumor reduction and conservative surgery. It is proposed in some studies that there may be an alteration in the hormonal receptor (HR) status and human epidermal growth factor receptor 2 (Her-2)/neu immune-expression followi...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.200669
更新日期：2016-07-01 00:00:00
abstract：:Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the report...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.146774
更新日期：2014-07-01 00:00:00
abstract：:Cancer is a manifestation of dysregulated gene function arising from a complex interplay of oncogenes and tumor suppressor genes present in our body. Cancer has been constantly chased using various therapies but all in vain as most of them are highly effective only in the early stages of cancer. Recently, RNA interfer...
journal_title：Indian journal of cancer
pub_type： 杂志文章,评审
doi：10.4103/0019-509X.175598
更新日期：2015-01-01 00:00:00
abstract：:Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：PURPOSE:The aim of this prospective study was to evaluate the effects of radiotherapy (RT) on psychiatric disorder in patients undergoing RT for head and neck cancer. MATERIALS AND METHODS:The prospective study included 51 patients with head and neck cancer. The diagnosis of psychiatric disorder was made by Diagnostic...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：10.4103/0019-509X.180816
更新日期：2016-01-01 00:00:00
abstract：:We have studied fibrinolytic activity of 12 cases of infiltrating duct carcinoma of breast (7 metastatic and 5 non-metastatic) and ten cases of adenocarcinoma of gastrointestinal tract (5 each of metastatic and nonmetastatic), and compared with some of their normal tissue counterparts. Both metastatic and non-metastat...
journal_title：Indian journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
