Abstract:
BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatinib. SETTINGS AND DESIGN:A noncurrent clinical trial study. MATERIALS AND METHODS:New incident CML patients received Iranian made or Indian-made Imatinib after baseline measurement. Hematologic, BCR-ABL, electrolytes and liver function enzymes measured again after 24 weeks. STATISTICAL ANALYSIS USED:Paired t-test and independent t-test was used to assess the effect of treatment in within and between groups, respectively. RESULTS:Imatinib has a decreasing impact on white blood cells and placates. While an increasing effect on hemoglobin concentration. Iranian made and Indian-made Imatinib has a same effect on improvement of hematologic, BCR-ABL, electrolytes in CML patients. However, the liver changes of Imatinib were not clinically significant. CONCLUSION:The Iranian-made Imatinib can be used as a replacement for Indian made ones without any statistical and clinical significant difference on Improvement of CML patients.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Moshfeghi K,Nazemizadeh N,Mehrzad V,Hajiannejad A,Esmaeili F,Mohammadbeigi Adoi
10.4103/0019-509X.176715subject
Has Abstractpub_date
2015-07-01 00:00:00pages
305-7issue
3eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2015_52_3_305_176715journal_volume
52pub_type
杂志文章abstract:BACKGROUND:Recently published prospective clinical trials and two meta-analyses have shown that addition of induction chemotherapy (IC) to concurrent chemoradiation (CRT) could potentially improve outcomes in comparison to CRT alone, in locoregionally advanced nasopharyngeal carcinoma (LANPC). Although it remains uncle...
journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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doi:
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pub_type: 杂志文章
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