Hematologic, liver enzymes and electrolytes changes in chronic myeloid leukemia after Imatinib medication.

Abstract:

BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatinib. SETTINGS AND DESIGN:A noncurrent clinical trial study. MATERIALS AND METHODS:New incident CML patients received Iranian made or Indian-made Imatinib after baseline measurement. Hematologic, BCR-ABL, electrolytes and liver function enzymes measured again after 24 weeks. STATISTICAL ANALYSIS USED:Paired t-test and independent t-test was used to assess the effect of treatment in within and between groups, respectively. RESULTS:Imatinib has a decreasing impact on white blood cells and placates. While an increasing effect on hemoglobin concentration. Iranian made and Indian-made Imatinib has a same effect on improvement of hematologic, BCR-ABL, electrolytes in CML patients. However, the liver changes of Imatinib were not clinically significant. CONCLUSION:The Iranian-made Imatinib can be used as a replacement for Indian made ones without any statistical and clinical significant difference on Improvement of CML patients.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Moshfeghi K,Nazemizadeh N,Mehrzad V,Hajiannejad A,Esmaeili F,Mohammadbeigi A

doi

10.4103/0019-509X.176715

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

305-7

issue

3

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2015_52_3_305_176715

journal_volume

52

pub_type

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