Abstract:
Background:Despite the advances in screening during the past decades, colorectal cancer (CRC) still is a leading cause of cancer deaths worldwide. Therefore, the development of new diagnostic methods is necessary. Aim:The aim of this study was to compare methylation changes of SRY-Box 21 (SOX21) gene promoter in tumor tissues and their normal adjacent mucosa in patients with CRC and to examine the relationship between the methylation levels and demographic/clinicopathological factors. Materials and methods:A total of 41 CRC patients participated in the present study. After the extraction of DNA and bisulfite treatment of the samples, the methylation levels were determined by using the MethyLight method. Statistical analysis:Two-sided Mann-Whitney U test was used to compare the median level of methylation in tumor tissues and their adjacent normal mucosa. Results:The methylation rates in tumor tissue samples were significantly higher compared to their adjacent normal mucosa (P < 0.0001). No association between demographic/clinicopathological factors and methylation status observed in tumor tissues. A receiver operating characteristics curve was constructed and tissue samples exhibited a sensitivity of 80.5% and specificity of 97.6% for SOX21 promoter methylation. Conclusion:The results of this study indicated the high potential of SOX21 gene promoter methylation as a candidate noninvasive diagnostic biomarker in stool and plasma of colorectal cancer patients. However, further studies with larger sample sizes are required to evaluate the specific role of SOX21 methylation as a biomarker for early detection of CRC.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Moradi K,Babaei E,Rezvani N,Safaralizadeh R,Bashiri H,Feizi MAHdoi
10.4103/ijc.IJC_542_18subject
Has Abstractpub_date
2020-04-01 00:00:00pages
166-171issue
2eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2020_57_2_166_284477journal_volume
57pub_type
杂志文章abstract:BACKGROUND:The Ewing sarcoma family of tumors (ESFT) are aggressive malignant tumors with small round cell morphology affecting mainly children and adolescents. The aim of this study is to classify the histological diversity and clinical characteristics of ESFT in children from a Tertiary Care Center in South India. M...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176700
更新日期:2015-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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abstract:: ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.35810
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abstract::Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage II...
journal_title:Indian journal of cancer
pub_type: 杂志文章
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journal_title:Indian journal of cancer
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.65316
更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.64723
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_110_19
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.200677
更新日期:2016-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.64717
更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.178407
更新日期:2015-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.204767
更新日期:2016-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.138271
更新日期:2014-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:In India, NGOs play a key role in creating a supportive environment for the control of tobacco consumption. AIMS:This study was conducted to assess the scope and the extent to which community-based women organizations are involved in tobacco control activities. To assess the scope and extent of participatio...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.63868
更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.63011
更新日期:2010-04-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.98906
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.104499
更新日期:2012-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.219595
更新日期:2017-01-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.58859
更新日期:2010-01-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.154058
更新日期:2014-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.176715
更新日期:2015-07-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.107753
更新日期:2012-10-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00