Is histologic differentiation a prognostic indicator for gastric carcinoma patients with curative resection?

Abstract:

BACKGROUND:The prognostic relevance of histologic differentiation in gastric carcinoma patients with curative resection is unclear. We analyzed the clinicopathologic features of gastric carcinoma patients with curative resection according to the histologic differentiation and evaluated surgical outcome. MATERIALS AND METHODS:Of 1198 gastric carcinoma patients with curative resection (American joint committee on cancer, Stages I-III), 274 (22.9%) had well-differentiated, 331 (27.6%) had moderately differentiated and 593 (49.5%) had poorly differentiated gastric carcinomas. RESULTS:Patients with the poorly differentiated type had more prominent serosal invasion, much more lymph node involvement and more advanced stage than patients with the well-differentiated type. The overall survival rate was higher for patients with a well-differentiated gastric carcinoma than for patients with a poorly differentiated type. Using Cox's proportional hazard regression model, histologic differentiation was found to be a statistically significant prognostic parameter (risk ratio, 1.41; 95% confidence interval, 1.028-1.922; P < 0.05). CONCLUSION:Our results suggest that patients with a well-differentiated gastric carcinoma have a good prognosis compared with those with a poorly differentiated type. Therefore, histologic differentiation can be used as a prognostic indicator in gastric carcinoma patients with curative resection.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Ryu SY,Kim HG,Joo JK,Kang H,Lee JH,Kim DY

doi

10.4103/0019-509X.175569

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

45-7

issue

1

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2015_52_1_45_175569

journal_volume

52

pub_type

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