Abstract:
BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This study aims to analyze the incidence, clinical picture, risk factors, management, and outcome of SIADH during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS:A prospective study was conducted among the 166 newly diagnosed pediatric ALL patients who were treated at a tertiary cancer center in India between January 2015 and December 2015. Patients who developed hyponatremia during induction chemotherapy were further investigated for SIADH. RESULTS:The incidence of SIADH was 10.8% (n = 18) with a mean sodium level of 125 mEq/L (114-129 mEq/L). In the preceding 2 weeks, 72% of episodes were associated with the administration of two (n = 6) or three (n = 7) doses of VCR. One child presented with seizures. All the patients were managed with fluid restriction and only two patients required sodium correction with 3% saline. Girls older than 10 years of age showed a marginally significant correlation to develop SIADH (P-value = 0.059). CONCLUSION:We report a higher incidence of SIADH (10.8%) in Indian children, compared to that described in the literature, during induction chemotherapy for ALL. Regular monitoring of sodium levels during this period of chemotherapy is hence essential for the timely diagnosis and appropriate management of SIADH, which in turn will avert complications, including neurological symptoms secondary to SIADH.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Seetharam S,Thankamony P,Gopakumar KG,Krishna KMJdoi
10.4103/ijc.IJC_737_18subject
Has Abstractpub_date
2019-10-01 00:00:00pages
320-324issue
4eissn
0019-509Xissn
1998-4774pii
IndianJournalofCancer_2019_56_4_320_267603journal_volume
56pub_type
杂志文章abstract:OBJECTIVE:This study aimed to evaluate the outcome of benign vocal cord tumors treated using a laryngeal endoscopy under low temperature-controlled radiofrequency and to elucidate the application of a dynamic laryngoendoscopy in the operation. MATERIALS AND METHODS:85 patients with benign vocal cord tumors were treate...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.151994
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:We have reported here the 5-year incidence (2004-2008) of gallbladder cancer (GBC) in North Central India along with its descriptive epidemiology. This provides potential clues for better prevention. The present study has also evaluated the association of ABO blood groups with GBC. PATIENTS AND METHODS:The ...
journal_title:Indian journal of cancer
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doi:10.4103/0019-509X.176736
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journal_title:Indian journal of cancer
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doi:
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journal_title:Indian journal of cancer
pub_type: 杂志文章
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abstract:BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to ...
journal_title:Indian journal of cancer
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doi:10.4103/0019-509X.175321
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abstract::Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...
journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
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journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Indian journal of cancer
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doi:
更新日期:2001-06-01 00:00:00
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journal_title:Indian journal of cancer
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doi:
更新日期:2000-03-01 00:00:00
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journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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更新日期:2016-01-01 00:00:00
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journal_title:Indian journal of cancer
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doi:
更新日期:1992-12-01 00:00:00
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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doi:
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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journal_title:Indian journal of cancer
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