Abstract:
:L-asparaginase is a valuable chemotherapeutic agent used in the induction of remission and improvement of long term survival in patients with acute lymphoblastic leukemia. Hyperglycemia is a well known side effect of L-asparaginase. Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin. Hyperglycemia was observed after a mean of five doses of L-asparaginase (range 2-10). Seven of fourteen patients had neutropenic related infective episodes. Hyperglycemia resolved in all patients within 12 days (range 4-25) and two patients died of neutropenic septicemia. During reinduction therapy with the same drugs, only one out of ten patients developed hyperglycemia E-coli-L-asparaginase was replaced by Erwinia asparaginase in two patients one of who had recrudescence on further therapy. Close monitoring during L-asparaginase therapy for hyperglycemia will enable prompt recognition and early correction and prevent delay in therapy of acute lymphoblastic leukemia.
journal_name
Indian J Cancerjournal_title
Indian journal of cancerauthors
Iyer RS,Rao SR,Pai S,Advani SH,Magrath ITsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
72-6issue
2eissn
0019-509Xissn
1998-4774journal_volume
30pub_type
杂志文章abstract:BACKGROUND:The Indian government enacted 'The cigarettes and other tobacco products act, 2003' (COTPA), which prohibits smoking in public places. AIM:To validate the efficacy of the Act of 2003, enacted by the Government of India, to prevent secondhand smoking in public places. SETTINGS AND DESIGN:The study is based ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.65316
更新日期:2010-07-01 00:00:00
abstract::Rat sarcoma viral oncogene homolog (RAS) and B-Raf murine sarcoma viral oncogene homolog B1 (BRAF) are members of the same signaling pathway (RAS-RAF-mitogen-activated protein kinase (MAPK) in colorectal cancer (CRC). It is generally assumed that BRAF mutations are seen only with wild-type RAS in CRC. But RAS and BRAF...
journal_title:Indian journal of cancer
pub_type:
doi:10.4103/ijc.IJC_430_18
更新日期:2019-04-01 00:00:00
abstract::Lymphnode infarction is seen in two sets of situations viz. spontaneous banal infarction of non-neoplastic nodes, and in association with lymphoma. It needs to be differentiated from other causes of lymphnode as a phenomenon occurring synchronous with and occasionally preceding diagnosis of lymphoma is significant. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:Background:Ki-67 index is an important prognostic marker in breast cancer and is also used to differentiate luminal A subtype from luminal B. Inter-observer variations in determining the index and the cut-off value to be considered in distinguishing the two subtypes remain problems in clinical practice. Methods:MIB-1 ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_719_18
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:Historically, metastatic renal cell carcinoma (RCC) has had poor prognosis; the outcomes have improved with the introduction of tyrosine-kinase inhibitors, such as sunitinib. There is no reported literature from India on the use of sunitinib in metastatic RCC. We present an analysis of sunitinib at our ins...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.118725
更新日期:2013-07-01 00:00:00
abstract::In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases includi...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.107735
更新日期:2012-10-01 00:00:00
abstract::Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the report...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Since 1987, 560 patients have been treated in our department for carcinoma of thyroid with radioactive Iodine-131. Recently, we have come across a patient with bilateral pulmonary concentration of Iodine-131, that is visualised on Iodine-131 whole body scintiscan, whereas chest radiogram was negative. Respectively, th...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::This report documents the occurrence of an extragonadal malignant teratoma on the sole of the foot, in a young male. The patient also developed a groin nodule showing the same histology. The testes, retroperitoneum and mediastinum, which are usual sites of germ cell tumours were all normal, and no other primary could ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Lymphedema following breast cancer treatment is one of the most morbid conditions affecting breast cancer survivors. Currently, no therapy completely cures this condition. Comprehensive Decongestive Therapy (CDT), a novel physiotherapeutic method offers promising results in managing this condition. This ther...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.92250
更新日期:2011-10-01 00:00:00
abstract::Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors incl...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.76625
更新日期:2011-01-01 00:00:00
abstract::The ultimate progress in the cancer diagnosis and therapy has only been possible with the ongoing translational research that is likely to play a very important role in future as well. Hence the importance of such translation from bedside to bench and vis versa cannot be over-emphasized. Accordingly it has become more...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509x.31163
更新日期:2007-01-01 00:00:00
abstract::Background: Cervical cancer being a major cause of morbidity and mortality in women in developing countries, its awareness is essential. Aim: The aim of this study is to assess the knowledge, attitude and practices of women regarding the basic screening test for detection of cancer cervix. Settings and Design: Populat...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.146780
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:In our center, we routinely use CCNU (Lomustine) as salvage treatment in high-grade glioma patients who cannot afford bevacizumab. This exploratory analysis was done to report the efficacy and toxicity associated with this regimen. METHODS:Patients who were treated with salvage CCNU (postexposure to temoz...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.204774
更新日期:2016-10-01 00:00:00
abstract::In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the ce...
journal_title:Indian journal of cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:Background:Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods:Seventy patients diagn...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_459_19
更新日期:2020-12-10 00:00:00
abstract::Basaloid Squamous Carcinoma (BSC) is an uncommon aggressive neoplasm occurring in the upper aerodigestive tract. Lung as a primary site has only recently been reported. A combination of microscopic features is required to make a diagnosis and to differentiate it from other more common malignancies in these sites. Thre...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
abstract::Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were als...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persis...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.82901
更新日期:2011-04-01 00:00:00
abstract:AIMS:Volumetric modulated arc radiotherapy (VMAT) is used for inoperable, locally advanced nonsmall cell lung cancer, where three-dimensional conformal radiotherapy (3D-CRT) cannot yield an acceptable plan. METHODS:The planning and treatment data were prospectively collected on the first 18 patients treated using VMAT...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_79_17
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of patients of renal cell carcinoma (RCC) with inferior vena caval (IVC) thrombus treated by radical nephrectomy and IVC thrombectomy in terms of clinical and pathological factors and prognosis. MATERIALS AND METHODS:Sixty-three consecutive patients of RCC with IVC thrombus who underwen...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509x.35810
更新日期:2007-04-01 00:00:00
abstract::A study of knowledge, attitude and practice with regard to tobacco usage was conducted in 1278 boys and 353 girls studying in the final year in various schools in Bombay. The proportion of boys given to one or the other form of tobacco usage (including experimenters/triers) was significantly higher in private English ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:This study was undertaken to report the results of weekly combination chemotherapy with cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (R/M SCCHN). MATERIALS AND METHODS:Retrospective analysis of 35 R/M SCCHN patients who received cetuximab with weekly paclitaxel and platin (cisplat...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.98906
更新日期:2012-01-01 00:00:00
abstract:CONTEXT:Cancer profile varies in different regions and depends on race, lifestyle and diet. The study of a cancer profile helps to know the common cancers in a particular population, its probable risk factors and also helps in cancer control programs. AIM:To study the cancer profile at Kolar, based on Pathology Depart...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.63011
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Lymphoma combined with hepatitis B infection occupies a relatively higher incidence in China than that of in Europe and America. AIMS:To observe the efficacy and safety of rituximab in combination with chemotherapy in patients with B-cell non-Hodgkin's lymphoma (NHL) and hepatitis B virus (HBV) infection. ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/0019-509X.200679
更新日期:2016-07-01 00:00:00
abstract::Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mu...
journal_title:Indian journal of cancer
pub_type:
doi:10.4103/ijc.IJC_545_17
更新日期:2017-12-01 00:00:00
abstract::It is important to differentiate non-dyplastic aplastic anaemia from hypocellular myelodysplastic syndrome (MDS). Four patients presenting with hypocellular bone marrow and different evolution patterns are being described. Certain morphological features and variable hypocellularity were found to be useful indices for ...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:CONTEXT:Malnutrition is prevalent in children with cancer at diagnosis, especially in low- and middle-income countries (LMIC) where the great majority of children live. It is associated with an added burden of morbidity and mortality. AIMS:Answers were sought to the best measure of nutritional status in LMIC, the impa...
journal_title:Indian journal of cancer
pub_type: 杂志文章,评审
doi:10.4103/0019-509X.175827
更新日期:2015-04-01 00:00:00
abstract::Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:Background:Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL). Methods:In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived inducti...
journal_title:Indian journal of cancer
pub_type: 杂志文章
doi:10.4103/ijc.IJC_110_19
更新日期:2021-01-06 00:00:00