A novel frameshift mutation in the MLH1 gene in a patient with Lynch syndrome.

Abstract:

:A novel mutation in the MLH1 gene likely to be pathogenic for Lynch syndrome was discovered in a proband with a family history of colon cancer. Immunohistochemistry showed negative expression of PMS2 and MLH1 in the resected tumor sample. The mutation lies at the highly conserved C-terminus of the MLH1 protein, the region through which it dimerizes with PMS2 to carry out its mismatch repair function.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Pandey AS,Shrestha S

doi

10.4103/ijc.IJC_349_18

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

410-412

issue

4

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2018_55_4_410_253292

journal_volume

55

pub_type

  • Risk predictors for adverse outcome in pediatric febrile neutropenia: Single center experience from a low and middle-income country.

    abstract:BACKGROUND:Risk stratification of patients with febrile neutropenia (FN) into those at "High Risk" and "Low Risk" of developing complications helps in making decisions regarding optimal treatment, such as whether to treat with oral or intravenous antibiotics, whether to treat as inpatient or outpatient and how long to ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.175321

    authors: Prasad M,Chinnaswamy G,Arora B,Vora T,Hawaldar R,Banavali S

    更新日期:2014-10-01 00:00:00

  • Immunoprofile of Hodgkin's lymphoma in India.

    abstract:AIMS AND BACKGROUND:The immunoprofile of the Reed Sternberg cell with respect to immunoreactivity for CD20 and lack of CD15 has been described as a poor prognostic factor. Large scale studies analyzing the immunoprofile of Hodgkin's lymphoma (HL) from India are lacking. The aim of this study was to obtain baseline info...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.41772

    authors: Patkar N,Mehta J,Kulkarni B,Pande R,Advani S,Borges A

    更新日期:2008-04-01 00:00:00

  • Systemic bacterial infections in bone marrow transplant patients.

    abstract::The clinical microbiology department at CMC&H, Vellore in conjunction with the haematology department carries out routine surveillance of patients admitted to the hematology department. Since 1994 in a sample population of 55 patients with various underlying clinical conditions who have had bone marrow transplant, sep...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Lalitha MK,Pai R,Manoharan A,Jesudason MV,Brahmadathan KN,Srivastava A,Chandy M

    更新日期:2000-03-01 00:00:00

  • Port site metastasis subsequent to laparoscopy for chronic pelvic pain.

    abstract::We present an interesting case of port site metastasis is a menopausal women subsequent to diagnostic laparoscopy undertaken for chronic pelvic pain, which later proved early ovarian malignancy as the source of primary. While cases of port site metastasis have mostly occurred after extensive disease the possbility of ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Malhotra N,Deka D,Takkar D,Malhotra B

    更新日期:2001-03-01 00:00:00

  • Mitochondria and tumors: a new perspective.

    abstract:BACKGROUND:Mitochondrial DNA (Mt DNA) defects have been identified in a variety of Tumors, but the exact role of these defects in the pathogenicity and tumor progression is poorly understood. This study aims at identifying the status of mitochondrial OXPHOS genes in neoplastic transformation and attempts to establish a...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.118732

    authors: Chintha R,Kaipa PR,Sekhar N,Hasan Q

    更新日期:2013-07-01 00:00:00

  • Bio-informatics analysis of renal carcinoma gene matrix metalloproteinase-7.

    abstract:BACKGROUND:Renal cancer is one of the common malignant tumors of the urinary system, seriously threatening human being's health. The current discoveries, however, are far enough for efficient and secure treatment of renal cancer. AIMS:The aim was to explore the mechanism of matrix metalloproteinase-7 (MMP-7) protein i...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.180835

    authors: Li L,Wang LX,Xu GL,Yang F,Gao QL,Niu H,Shi B,Jiang X

    更新日期:2016-01-01 00:00:00

  • Comprehensive decongestive therapy in postmastectomy lymphedema: an Indian perspective.

    abstract:BACKGROUND:Lymphedema following breast cancer treatment is one of the most morbid conditions affecting breast cancer survivors. Currently, no therapy completely cures this condition. Comprehensive Decongestive Therapy (CDT), a novel physiotherapeutic method offers promising results in managing this condition. This ther...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.92250

    authors: Randheer S,Kadambari D,Srinivasan K,Bhuvaneswari V,Bhanumathy M,Salaja R

    更新日期:2011-10-01 00:00:00

  • Hypofractionated radiotherapy in carcinoma cervix IIIB: Tata Memorial Hospital experience.

    abstract:PURPOSE OF THE STUDY:To analyze the role of hypofractionated radiotherapy in advanced carcinoma of cervix. BASIC PROCEDURE:Medical records of 62 women with advanced carcinoma cervix III3 treated during 1994-1996 were reviewed. Patients were treated with standard pelvic portals to a total dose of 39Gy in 13 fractions o...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Muckaden MA,Budrukkar AN,Tongaonkar HB,Dinshaw KA

    更新日期:2002-10-01 00:00:00

  • Primary gastrointestinal non Hodgkin's lymphoma chemotherapy alone an effective treatment modality: experience from a single centre in India.

    abstract:BACKGROUND:Gastrointestinal tract (GI) is the most frequently involved extra nodal site in non-Hodgkin's lymphoma (NHL). Surgery, radiotherapy and chemotherapy (CT) have been used mostly in various combinations, but lately chemotherapy alone has emerged as an effective option. The purpose of this study is to evaluate e...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.25773

    authors: Raina V,Sharma A,Vora A,Shukla NK,Deo SV,Dawar R

    更新日期:2006-01-01 00:00:00

  • Frequency of bacterial isolates and pattern of antimicrobial resistance in patients with hematological malignancies: A snapshot from tertiary cancer center.

    abstract:BACKGROUND:Infections are the most important cause of mortality in patients with high-risk febrile neutropenia. Emergence of multi-drug resistant organisms (MDROs) has become a major challenge for hemato-oncologists. Knowledge of the prevalent organisms and their antimicrobial sensitivity can help deciding the empirica...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.175387

    authors: Sengar M,Kelkar R,Jain H,Biswas S,Pawaskar P,Karpe A

    更新日期:2014-10-01 00:00:00

  • Carcinoma of buccal mucosa: incidence of regional lymph node involvement.

    abstract::Histopathological findings in 57 surgical specimens of T3 and T4 buccal mucosa cancers are reviewed. The incidence of the well-differentiated tumours (including verrucous carcinoma) was 61%. A moderate degree of lymphocytic infiltration of the tumour was present in 37% of patients. Histologically proven cervical lymph...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Dhawan IK,Verma K,Khazanchi RK,Madan NC,Shukla NK,Saxena R

    更新日期:1993-12-01 00:00:00

  • Adrenal cortical carcinoma in Thailand: a review on the previous reported case.

    abstract:BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.123611

    authors: Joob B,Wiwanitkit V

    更新日期:2013-10-01 00:00:00

  • The founding of the Tata Memorial Hospital, 1932-1941.

    abstract::This article presents a brief account of the founding of the Tata Memorial Hospital. It draws upon archival material to show that this was not a mere philanthropic act but a scheme carefully thought-out by the Trustees of the Sir Dorabji Tata Trust. It discusses the major concerns of the Trustees as they deliberated u...

    journal_title:Indian journal of cancer

    pub_type: 历史文章,杂志文章

    doi:10.4103/ijc.IJC_13_19

    authors: Kavadi SN

    更新日期:2019-07-01 00:00:00

  • Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

    abstract::Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...

    journal_title:Indian journal of cancer

    pub_type:

    doi:10.4103/ijc.IJC_260_18

    authors: Totadri S,Sundersingh S,Natarajan R,Seshadri RA,Radhakrishnan V

    更新日期:2018-07-01 00:00:00

  • Incidence and characteristics of Epidermal Growth Factor Receptor (EGFR) mutation in non-small-cell lung cancer (Adenocarcinoma histology): A report of 106 patients from Kolkata.

    abstract:CONTEXT:Regional epidemiological data regarding the epidermal growth factor receptor (EGFR) mutation status in non-small-cell lung cancers (NSCLC) is an unmet need from the eastern part of India. AIMS:To report the incidence of EGFR mutation and its correlation with the phenotypical characteristics, in NSCLC patients ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

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    authors: Chatterjee K,Ray A,Chattopadhyay B

    更新日期:2017-01-01 00:00:00

  • Chemosuppressive effect of plumbagin on human non-small lung cancer cell xenotransplanted zebrafish.

    abstract:BACKGROUND:Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) derived from Plumbago species is a potential anti-tumour agent. Plumbagin has been tested for anti-cancer activity in vitro and in vivo using mice model. AIM:To study the tumour suppressing efficacy of plumbagin using zebrafish model. MATERIALS AND METHODS:H...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.219580

    authors: Vinothkumar R,Ceasar SA,Divyarupa A

    更新日期:2017-01-01 00:00:00

  • Tolerance and toxicity of neoadjuvant docetaxel, cisplatin and 5 fluorouracil regimen in technically unresectable oral cancer in resource limited rural based tertiary cancer center.

    abstract:BACKGROUND:Recent studies indicate neoadjuvant chemotherapy (NACT) can result in R0 resection in a substantial proportion of patients with technically unresectable oral cavity cancers. However, data regarding the efficacy and safety of docetaxel, cisplatin and 5 fluorouracil (TPF) NACT in our setting is lacking. The pr...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.134649

    authors: Patil VM,Chakraborty S,Shenoy PK,Manuprasad A,Sajith Babu TP,Shivkumar T,Babu S,Bhatterjee A,Balasubramanian S

    更新日期:2014-01-01 00:00:00

  • Management of metastatic Wilms tumor: an eleven year experience.

    abstract::During the last 11 years, 101 patients of Wilms tumor were seen. Of these, 13 patients had metastatic disease at onset while 24 patients presented with relapse at a latter date. Seven patients have been cured, all had favourable histology. The risk factors associated with relapse were found to be unfavourable histolog...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Misra D,Gupta DK,Mitra DK,Bhatnagar V,Bajpai M,Mathur M,Rohatgi M

    更新日期:1996-03-01 00:00:00

  • Metachronous multicentric giant-cell tumour: a case report.

    abstract::Giant-cell Tumours (GCT) of bone are not uncommon but a primary multicentric giant-cell tumour is very rare. This reported case represents a true multicentric giant-cell tumour with four lesions. These lesions had only curettage with no recurrence. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Sadat-Ali M

    更新日期:1997-12-01 00:00:00

  • Mature ovarian teratoma with gliomatosis peritonei--a case report.

    abstract::Gliomatosis peritonei (GP), a rare condition related to ovarian teratomas, is characterized by miliary implants of mature glial tissues on the peritoneum or omentum. We report herein a case of mature teratoma of the ovary with GP with imaging features and pathological correlation. ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.17064

    authors: Das CJ,Sharma R,Thulkar S,Mukhopadhyay S,Deka D,Mannan R

    更新日期:2005-07-01 00:00:00

  • The Chennai Declaration: a roadmap to tackle the challenge of antimicrobial resistance.

    abstract::"A Roadmap to Tackle the Challenge of Antimicrobial Resistance - A Joint meeting of Medical Societies in India" was organized as a pre-conference symposium of the 2 nd annual conference of the Clinical Infectious Disease Society (CIDSCON 2012) at Chennai on 24 th August. This was the first ever meeting of medical soci...

    journal_title:Indian journal of cancer

    pub_type:

    doi:10.4103/0019-509X.104065

    authors: Ghafur A,Mathai D,Muruganathan A,Jayalal JA,Kant R,Chaudhary D,Prabhash K,Abraham OC,Gopalakrishnan R,Ramasubramanian V,Shah SN,Pardeshi R,Huilgol A,Kapil A,Gill J,Singh S,Rissam HS,Todi S,Hegde BM,Parikh P

    更新日期:2013-01-01 00:00:00

  • Damage to the anterior visual pathway and brain parenchyma following external pituitary irradiation.

    abstract::Three cases of damage to the optic nerves and chiasma following pituitary irradiation with Co60 teletherapy are described. All of them presented with progressive visual impairment months following irradiation and simulated recurrence of the tumour. CT scan was also not helpful in differentiating radionecrosis from tum...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:

    authors: Kundra SN,Sharma BS,Banerjee AK,Ayyagari S,Dhir SP,Kak VK

    更新日期:1990-09-01 00:00:00

  • Complimentary role of FDG-PET imaging and skeletal scintigraphy in the evaluation of patients of prostate carcinoma.

    abstract::Prostate cancer is one of the most common malignancies of elderly males. Management depends on the accurate estimation of disease both at initial diagnosis and in its subsequent course. In the present study, we evaluated the diagnostic utility of positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) in p...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.73572

    authors: Tiwari BP,Jangra S,Nair N,Tongaonkar HB,Basu S

    更新日期:2010-10-01 00:00:00

  • Ovarian tumors in children: 10-year experience from a tertiary care center in South India.

    abstract:BACKGROUND:Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with resp...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.197726

    authors: Rajeswari B,Nair M,Ninan A,Parukuttyamma K

    更新日期:2016-04-01 00:00:00

  • Study of the RET gene and his implication in thyroid cancer: Morocco case family.

    abstract:BACKGROUND:Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that affects multiple tissues derived from the neural crest. Inheritance of MTC is related to the presence of specific mutations in the RET proto-oncogene. Almost all mutations in MEN 2A involve one of the cystei...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509x.27934

    authors: Ainahi A,Kebbou M,Timinouni M,Benabdeljalil N,Fechtali T,Oufara S,El Antri S

    更新日期:2006-07-01 00:00:00

  • A prospective randomized trial comparing capecitabine-based chemoradiotherapy with 5-FU-based chemoradiotherapy in neoadjuvant setting in locally advanced carcinoma rectum.

    abstract:INTRODUCTION:Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/ijc.IJC_174_17

    authors: Singh K,Gupta MK,Seam RK,Gupta M

    更新日期:2017-01-01 00:00:00

  • Factors influencing the evaluation of an article in cancer literature.

    abstract::Casual Interpretation of results in a given article has several pitfalls. In order to assess the strengths and limitations of a given article several factors need to be considered. This review article is intended to list, classify and describe briefly the factors that should be considered in the evaluation of an artic...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Kumaraswamy,Supe SS,Ramesh C

    更新日期:1999-06-01 00:00:00

  • Design, architecture and application of nanorobotics in oncology.

    abstract::Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dre...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:10.4103/0019-509X.175805

    authors: Saxena S,Pramod BJ,Dayananda BC,Nagaraju K

    更新日期:2015-04-01 00:00:00

  • Monotherapy versus combination therapy against carbapenem-resistant Gram-negative bacteria: A retrospective observational study.

    abstract:BACKGROUND:Colistin-based combination therapy (CCT) is extensively used to treat infections due to carbapenem-resistant Gram-negative bacteria (CRGNB). There are no data available from India on the usefulness of combination therapy, especially in the oncology setup. The aim of this study was to analyze the clinical eff...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章

    doi:10.4103/0019-509X.204767

    authors: Ghafur A,Devarajan V,Raja T,Easow J,Raja MA,Sreenivas S,Ramakrishnan B,Raman SG,Devaprasad D,Venkatachalam B,Nimmagadda R

    更新日期:2016-10-01 00:00:00

  • Biological response modifiers: current use and future prospects in cancer therapy.

    abstract::Over the past few decades, considerable success has been achieved in the field of cancer treatment with biological response modifiers (BRM), which are agents that improve the body's ability to fight cancer by immunostimulation. Biological agents, such as interferons and interleukins, provide nonspecific active immunit...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审

    doi:10.4103/0019-509X.73559

    authors: Bisht M,Bist SS,Dhasmana DC

    更新日期:2010-10-01 00:00:00