Biological response modifiers: current use and future prospects in cancer therapy.


:Over the past few decades, considerable success has been achieved in the field of cancer treatment with biological response modifiers (BRM), which are agents that improve the body's ability to fight cancer by immunostimulation. Biological agents, such as interferons and interleukins, provide nonspecific active immunity, whereas the monoclonal antibodies provide passive immunity. Apart from this, other biological agents, such as antiangiogenic agents, matrix metalloprotease inhibitors, tyrosine kinase inhibitors, and tumor vaccines, are also increasingly being used in cancer treatment. Hematopoietic factors, such as granulocyte colony-stimulating factor, are used to increase the general immunity and prevent opportunistic infection. BRM are basically used alone or as adjuvants to cancer chemotherapeutic agents. This review sheds light on the current use and the future development of cancer immunotherapy. Search strategy included Pubmed, using the terms "Biological response modifiers in cancer" citations relevant to the topic were screened.


Indian J Cancer


Indian journal of cancer


Bisht M,Bist SS,Dhasmana DC




Has Abstract


2010-10-01 00:00:00














  • Harmonic scalpel versus conventional diathermy: Is one really better than the other?

    abstract:: ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Suhani.

    更新日期:2018-10-01 00:00:00

  • Chromosome analysis in effusions as a diagnostic adjunct to cytology.

    abstract::Cytogenetic analysis using G-banding techniques for the diagnosis of malignancy in pleural and peritoneal effusions is compared with the results of traditional cytomorphology. The studies indicate that the yield of mitotic cells in malignant effusions is quite high when compared to fluids with no cytological evidence ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Augustus M,Visveshwara RN,Bhargava MK

    更新日期:1989-06-01 00:00:00

  • Nutritional status in children with acute lymphoblastic leukemia, and its correlation with severe infection.

    abstract:Background:Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL). Methods:In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived inducti...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Sonowal R,Gupta V

    更新日期:2021-01-06 00:00:00

  • Determinants of oxidative stress and DNA damage (8-OhdG) in squamous cell carcinoma of head and neck.

    abstract:BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kumar A,Pant MC,Singh HS,Khandelwal S

    更新日期:2012-07-01 00:00:00

  • Young breast cancer: A single center experience.

    abstract:BACKGROUND:Breast cancer in women aged less than 35 years is uncommon and accounts for 1-2% of all breast cancer in the West. There is a paucity of data on young breast cancer from India. The aim of this study was to analyze the clinical, pathological, prognostic factors and outcome in young breast cancer patients. MA...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Gogia A,Raina V,Deo SV,Shukla NK,Mohanti BK

    更新日期:2014-10-01 00:00:00

  • Scope and extent of participation of female volunteers in tobacco control activities in Kerala, India.

    abstract:BACKGROUND:In India, NGOs play a key role in creating a supportive environment for the control of tobacco consumption. AIMS:This study was conducted to assess the scope and the extent to which community-based women organizations are involved in tobacco control activities. To assess the scope and extent of participatio...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Sreedharan J,Muttapppallymyalil J,Divakaran B

    更新日期:2010-07-01 00:00:00

  • Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

    abstract::Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropeni...

    journal_title:Indian journal of cancer



    authors: Totadri S,Sundersingh S,Natarajan R,Seshadri RA,Radhakrishnan V

    更新日期:2018-07-01 00:00:00

  • Assessment of chlorpromazine as radiation sensitizer and protector.

    abstract::In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the ce...

    journal_title:Indian journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Huilgol NG,Chatterjee N,Singh BB

    更新日期:1996-12-01 00:00:00

  • Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18-45 years: A case-control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history.

    abstract:BACKGROUND:Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. AIM:To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of th...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Dholam KP,Chouksey GC

    更新日期:2016-04-01 00:00:00

  • Hematologic, liver enzymes and electrolytes changes in chronic myeloid leukemia after Imatinib medication.

    abstract:BACKGROUND:Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS:This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatin...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Moshfeghi K,Nazemizadeh N,Mehrzad V,Hajiannejad A,Esmaeili F,Mohammadbeigi A

    更新日期:2015-07-01 00:00:00

  • Plasma cell leukemia: a retrospective study of 10 cases.

    abstract:BACKGROUND:Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma (MM) characterized by a fulminant course and poor prognosis. Flow cytometry (FCM) is very useful in the diagnosis of the plasma cell leukemia. Herein, we present 10 cases of PCL. MATERIALS AND METHODS:We retrospectively studied immu...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Agarwal AD,Brahmbhatt BS,Parikh BP,Shah MJ

    更新日期:2014-01-01 00:00:00

  • Study of the RET gene and his implication in thyroid cancer: Morocco case family.

    abstract:BACKGROUND:Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that affects multiple tissues derived from the neural crest. Inheritance of MTC is related to the presence of specific mutations in the RET proto-oncogene. Almost all mutations in MEN 2A involve one of the cystei...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Ainahi A,Kebbou M,Timinouni M,Benabdeljalil N,Fechtali T,Oufara S,El Antri S

    更新日期:2006-07-01 00:00:00

  • FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry 'Equivocal' interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center expe

    abstract:Background:Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Methods:We explored the prevalence of ROS1, ALK, MET mutations, discu...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Singh A,Kumar R,Shetty O,Desai S,Rane S

    更新日期:2020-11-24 00:00:00

  • Efficacy of second-line erlotinib in patients postprogression of first-line chemotherapy in head and neck cancers.

    abstract:BACKGROUND:Oral tyrosine kinase inhibitor (gefitinib and erlotinib) have been used in the palliative treatment of head and neck cancers with limited success. In this report, we aim to quantify the symptomatic benefit, progression-free survival (PFS) and overall survival (OS) when erlotinib is given as second-line treat...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Patil V,Karpe A,Noronha V,Joshi A,Muddu V,Bhattacharjee A,Dhumal S,Prabhash K

    更新日期:2015-10-01 00:00:00

  • Histopathological evaluation of surgically treated adult renal tumors: Report from a tertiary care center in India.

    abstract:BACKGROUND:This retrospective study was performed in a tertiary care center from India analyzing the histopathological reports and the clinical data of the adult patients admitted in this institute with a diagnosis of renal tumors and had undergone nephrectomy for the disease. OBJECTIVE:The objective of this study is ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Datta B,Giri A,Halder B

    更新日期:2016-01-01 00:00:00

  • Chylothorax in children with cancer: A milky predicament.

    abstract::Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series fro...

    journal_title:Indian journal of cancer



    authors: Totadri S,Trehan A,Bhattacharya A,Bansal D,Attri SV,Srinivasan R

    更新日期:2017-10-01 00:00:00

  • Myoepithelial expression of Fas and strong nuclear expression of FasL in epithelial cells: a marker for risk stratification of breast cancer.

    abstract:AIM:The clinical significance of Fas and FasL in hormone-sensitive carcinomas has been reported. Our objective was to evaluate the expression of apoptosis-regulating genes Fas and FasL in Indian breast cancer and fibroadenoma patients in relation to hormone receptor status. STUDY DESIGN:Retrospective. MATERIALS AND M...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Ranade KJ,Nerurkar AV,Phulpagar MD,Shirsat NV

    更新日期:2012-01-01 00:00:00

  • Histological diversity and clinical characteristics of Ewing sarcoma family of tumors in children: A series from a tertiary care center in South India.

    abstract:BACKGROUND:The Ewing sarcoma family of tumors (ESFT) are aggressive malignant tumors with small round cell morphology affecting mainly children and adolescents. The aim of this study is to classify the histological diversity and clinical characteristics of ESFT in children from a Tertiary Care Center in South India. M...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Priya D,Kumar RV,Appaji L,Aruna Kumari BS,Padma M,Kumari P

    更新日期:2015-07-01 00:00:00

  • Immunohistochemical detection of axillary lymph node micrometastases in breast cancer patients: Increasing the accuracy of detection and decreasing labor intensive serial sectioning.

    abstract::Background: The histological detection of axillary lymph node tumor metastases in cases of breast carcinoma is of major prognostic significance, but may be difficult when metastases are of microscopic size. The micrometastases can be detected either by immunohistochemistry (IHC) or serial sectioning. Aims: We investig...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Yadav R,Singh S,Marwah N,Kataria K,Aggarwal G,Sen R

    更新日期:2014-07-01 00:00:00

  • Damage to the anterior visual pathway and brain parenchyma following external pituitary irradiation.

    abstract::Three cases of damage to the optic nerves and chiasma following pituitary irradiation with Co60 teletherapy are described. All of them presented with progressive visual impairment months following irradiation and simulated recurrence of the tumour. CT scan was also not helpful in differentiating radionecrosis from tum...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kundra SN,Sharma BS,Banerjee AK,Ayyagari S,Dhir SP,Kak VK

    更新日期:1990-09-01 00:00:00

  • Frequency of bacterial isolates and pattern of antimicrobial resistance in patients with hematological malignancies: A snapshot from tertiary cancer center.

    abstract:BACKGROUND:Infections are the most important cause of mortality in patients with high-risk febrile neutropenia. Emergence of multi-drug resistant organisms (MDROs) has become a major challenge for hemato-oncologists. Knowledge of the prevalent organisms and their antimicrobial sensitivity can help deciding the empirica...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Sengar M,Kelkar R,Jain H,Biswas S,Pawaskar P,Karpe A

    更新日期:2014-10-01 00:00:00

  • Clinical profile and outcomes of patients with Stage IV adenocarcinoma of lung: A tertiary cancer center experience.

    abstract:BACKGROUND:There is limited Indian data on clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung. AIM:We aimed to prospectively study the clinical profile and treatment outcomes for patients with Stage IV adenocarcinoma of lung at a tertiary cancer center. MATERIALS AND METHODS:One...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Paliwal P,Rajappa S,Santa A,Mohan M,Murthy S,Lavanya N

    更新日期:2017-01-01 00:00:00

  • Time trend in frequency of occurrence of major immunophenotypes in paediatric acute lymphoblastic leukemia cases as experienced by Cancer Institute, Chennai, south India during the period 1989-2009.

    abstract:BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease and socioeconomic and environmental factors are considered to be an important determinant of its immunophenotype. The aim of this analysis is to study the time trend in the immunophenotype of pediatric acute lymphoblastic le...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Rajalekshmy KR,Abitha AR,Anuratha N,Sagar TG

    更新日期:2011-07-01 00:00:00

  • Carcinoma of buccal mucosa: incidence of regional lymph node involvement.

    abstract::Histopathological findings in 57 surgical specimens of T3 and T4 buccal mucosa cancers are reviewed. The incidence of the well-differentiated tumours (including verrucous carcinoma) was 61%. A moderate degree of lymphocytic infiltration of the tumour was present in 37% of patients. Histologically proven cervical lymph...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Dhawan IK,Verma K,Khazanchi RK,Madan NC,Shukla NK,Saxena R

    更新日期:1993-12-01 00:00:00

  • Therapy and progression--induced O6-methylguanine-DNA methyltransferase and mismatch repair alterations in recurrent glioblastoma multiforme.

    abstract::Despite multimodality treatment protocol including surgical resection, radiotherapy, and chemotherapy in patients with glioblastoma multiforme (GBM), most suffer from treatment failure and tumor recurrence within a few months of initial surgery. The effectiveness of temozolomide (TMZ), the most commonly used chemother...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Agarwal S,Suri V,Sharma MC,Sarkar C

    更新日期:2015-10-01 00:00:00

  • Concomitant RAS and BRAF mutation in colorectal cancer - A report of 7 cases.

    abstract::Rat sarcoma viral oncogene homolog (RAS) and B-Raf murine sarcoma viral oncogene homolog B1 (BRAF) are members of the same signaling pathway (RAS-RAF-mitogen-activated protein kinase (MAPK) in colorectal cancer (CRC). It is generally assumed that BRAF mutations are seen only with wild-type RAS in CRC. But RAS and BRAF...

    journal_title:Indian journal of cancer



    authors: Ates O,Yalcin S

    更新日期:2019-04-01 00:00:00

  • Chemistry and toxicology of smokeless tobacco.

    abstract::In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases includi...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章,评审


    authors: Bhisey RA

    更新日期:2012-10-01 00:00:00

  • Tobacco usage in school children in Bombay, India. A study of knowledge, attitude and practise.

    abstract::A study of knowledge, attitude and practice with regard to tobacco usage was conducted in 1278 boys and 353 girls studying in the final year in various schools in Bombay. The proportion of boys given to one or the other form of tobacco usage (including experimenters/triers) was significantly higher in private English ...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Jayant K,Notani PN,Gulati SS,Gadre VV

    更新日期:1991-09-01 00:00:00

  • Colloid cyst of the third ventricle: a cause of sudden death in a child.

    abstract::Colloid cyst is a rare benign intracranial neoplasm, commonly located in the third ventricle. Though headache and visual symptoms are classical, the patients may present with sudden neurological deterioration. We present a ten-year-old male child who presented with sudden neurological deterioration due to colloid cyst...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Kava MP,Tullu MS,Deshmukh CT,Shenoy A

    更新日期:2003-01-01 00:00:00

  • Adrenal cortical carcinoma in Thailand: a review on the previous reported case.

    abstract:BACKGROUND:Adrenal cortical carcinoma (ACC) is an uncommon cancer. MATERIALS AND METHODS:The author performed a literature review on the reports of ACC in Thailand in order to summarize the characteristics of this rare cancer among Thai patients. RESULTS:According to this study, there have been at least seven reports...

    journal_title:Indian journal of cancer

    pub_type: 杂志文章


    authors: Joob B,Wiwanitkit V

    更新日期:2013-10-01 00:00:00