Biological response modifiers: current use and future prospects in cancer therapy.

Abstract:

:Over the past few decades, considerable success has been achieved in the field of cancer treatment with biological response modifiers (BRM), which are agents that improve the body's ability to fight cancer by immunostimulation. Biological agents, such as interferons and interleukins, provide nonspecific active immunity, whereas the monoclonal antibodies provide passive immunity. Apart from this, other biological agents, such as antiangiogenic agents, matrix metalloprotease inhibitors, tyrosine kinase inhibitors, and tumor vaccines, are also increasingly being used in cancer treatment. Hematopoietic factors, such as granulocyte colony-stimulating factor, are used to increase the general immunity and prevent opportunistic infection. BRM are basically used alone or as adjuvants to cancer chemotherapeutic agents. This review sheds light on the current use and the future development of cancer immunotherapy. Search strategy included Pubmed, using the terms "Biological response modifiers in cancer" citations relevant to the topic were screened.

journal_name

Indian J Cancer

journal_title

Indian journal of cancer

authors

Bisht M,Bist SS,Dhasmana DC

doi

10.4103/0019-509X.73559

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

443-51

issue

4

eissn

0019-509X

issn

1998-4774

pii

IndianJournalofCancer_2010_47_4_443_73559

journal_volume

47

pub_type

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